Justin Z. Amarin
A5018607735- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Global Cancer Incidence and Screening
- Kawasaki Disease and Coronary Complications
- Global Health and Surgery
- Viral Infections and Vectors
- Tracheal and airway disorders
- Glioma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Childhood Cancer Survivors' Quality of Life
- Infectious Encephalopathies and Encephalitis
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Viral Infections and Outbreaks Research
- COVID-19 and healthcare impacts
- Multiple and Secondary Primary Cancers
Vanderbilt University Medical Center
2022-2025
Vanderbilt University
2024-2025
King Hussein Cancer Center
2020-2025
Monroe Carell Jr. Children's Hospital
2024
American Society of Safety Professionals
2023
University of Jordan
2017-2022
University of Maryland, Baltimore
2017
University of Maryland Medical Center
2017
The role of serologic testing for SARS-CoV-2 has evolved during the pandemic as seroprevalence in global populations increased. Infectious Diseases Society America (IDSA) convened an expert panel to perform a systematic review coronavirus disease 2019 (COVID-19) serology literature and construct updated best practice guidance related testing. This guideline is update fourth series rapid, frequently COVID-19 guidelines developed by IDSA.
Importance Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide. Objective To evaluate characteristics outcomes RSV-related critical illness in US infants during peak 2022 RSV transmission. Design, Setting, Participants This cross-sectional study used a public health prospective surveillance registry 39 pediatric hospitals across 27 states. were admitted for 24 or more hours between October 17 December 16,...
The COVID-19 pandemic has been associated with a transient decrease in bronchiolitis hospitalizations compared prepandemic patterns, but current effects remain unknown.To analyze changes patterns of admissions at US children's hospitals during the 2020-2023 seasons 2010-2019 seasons.This retrospective cross-sectional study used data from 41 Pediatric Health Information System database. Bronchiolitis winter-predominant seasonality, so were grouped according to season (from July through June)....
Abstract Background Lymph node ratio (LNR) may offer superior prognostic stratification in colorectal adenocarcinoma compared with N stage. However, candidate cutoff ratios require validation. We aimed to study the significance of LNR and its optimal ratio. Methods reviewed pathology records all patients stage III who were managed at King Hussein Cancer Center between January 2014 December 2019. then studied clinical characteristics patients, correlates lymph count, positive nodes, value...
Importance Studies of influenza in children commonly rely on coded diagnoses, yet the ability International Classification Diseases, Ninth Revision codes to identify emergency department (ED) and hospital is highly variable. The accuracy newer Statistical Diseases Related Health Problems, Tenth (ICD-10) unknown. Objective To determine ICD-10 discharge diagnosis pediatric ED inpatient settings. Design, Setting, Participants Children younger than 18 years presenting or settings with fever...
Pediatric respiratory syncytial virus (RSV)-related acute lower tract infection (LRTI) commonly requires hospitalization. The Clinical Progression Scale Pediatrics (CPS-Ped) measures level of support and degree hypoxia across a range disease severity, but it has not been applied in infants hospitalized with severe RSV-LRTI. We analyzed data from prospective surveillance registry for RSV-related complications 39 U.S. PICUs October through December 2022. assigned CPS-Ped (0=discharged home at...
Abstract Background Adult hematopoietic cell transplant (HCT) recipients are at high risk of influenza complications but have suboptimal immune responses to vaccines. Our previous phase II trial in adult HCT demonstrated that two doses high-dose trivalent vaccine (HD-TIV) were associated with higher hemagglutination inhibition (HAI) antibody than standard-dose quadrivalent (SD-QIV), similar safety profiles. This sub-study aims characterize immunogenicity and this vaccination strategy...
Abstract Background Despite recommendations from CDC and ACIP, antiviral prescription for children who are at higher risk of severe influenza (including those < 5 years with certain underlying conditions) in emergency departments (EDs) remains suboptimal. This study assessed changes EDs the pre-COVID-19-pandemic period to COVID-19 pandemic period. Demographic clinical characteristics influenza(1) enrolled ED laboratory confirmed influenza, stratified by periods (N=2,5001). (1) Defined...
Abstract Background Influenza-specific antivirals are recommended for all hospitalized children with suspected or confirmed influenza. However, antiviral use remains suboptimal. We investigated in influenza before the COVID-19 pandemic and during late period, as well factors associated use. Methods conducted active surveillance on < 18 years old acute respiratory illness at seven pediatric centers New Vaccine Surveillance Network (12/01/2016–03/31/2020) period (07/01/2021–03/31/2023)....
Abstract Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections in young children worldwide. With the recent wave regulatory approvals and authorizations for nirsevimab maternal RSV vaccines across several countries, understanding current burden seasonality crucial implementing effective preventive strategies globally. We aimed to determine burden, seasonality, co-detections hospitalized < 2 years old Amman, Jordan.Figure 1.Monthly proportion...
Abstract Background Human adenovirus (HAdV) is a common cause of acute respiratory illness (ARI) in children, ranging from asymptomatic to life-threatening disease. While previous studies have examined vs HAdV ARI infections, few analyzed species and type. We compared frequencies types among children with vs. healthy controls (HCs). Comparison demographics detection between controls: New Vaccine Surveillance Network 12/01/2016–11/30/2019 (N=1,393). Methods Data were the Network, multicenter,...
Abstract Objectives The etiology of biliary atresia (BA) is unclear and potentially involves viral triggers. We aimed to compare the incidence BA in United States before during coronavirus disease 2019 (COVID‐19) pandemic, focusing on potential associations with circulation disruptions caused by nonpharmaceutical interventions (NPIs). Methods queried Pediatric Health Information System® (PHIS) for all patients discharged between January 1, 2010, 31, 2024. Using CDC WONDER, we calculated...
Primary central nervous system (CNS) tumors are often associated with relatively poor outcomes. Data on the epidemiology and outcome of CNS in Jordan scarce. We aim to report primary patients managed at a comprehensive cancer care center Jordan. performed retrospective chart review all Jordanian tumor diagnosis who were between July 2003 June 2019. included entities described 2021 WHO classification system, addition pituitary neuroendocrine (PitNETs). used Kaplan-Meier method estimate...
ABSTRACT Inappropriate antibiotic use drives antimicrobial resistance, a global health threat causing increased morbidity and mortality. Understanding practices in low-resource settings is essential to identify intervention targets. This study investigates prescription Amman, Jordan. We conducted three prospective viral surveillance studies at the largest public hospital Jordan (2010–2013, 2020, 2023) included children <2 years old hospitalized with fever or respiratory symptoms. The data...
Abstract Background Human parainfluenza viruses (PIV) are a major cause of acute respiratory infection (ARI) leading to hospitalization in young children. In order quantify the burden PIV hospitalizations and evaluate characteristics children hospitalized with by virus type, we used data from New Vaccine Surveillance Network (NVSN), multicenter, active, prospective population-based surveillance network, enrolling for ARI (defined as fever and/or symptoms) at 7 U.S. children’s hospitals....
Rhinovirus (RV) is one of the most common etiologic agents acute respiratory infection (ARI), which a leading cause morbidity and mortality in young children. The clinical significance RV co-detection with other viruses, including syncytial virus (RSV), remains unclear. We aimed to compare characteristics outcomes children ARI-associated RV-only detection those co-detection-with an emphasis on RV/RSV co-detection.We conducted prospective viral surveillance study (11/2015-7/2016) Nashville,...
Abstract Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illnesses in children. RSV can be broadly categorized into 2 major subtypes: A and B. subtypes have been known to cocirculate with variability different regions the world. Clinical associations viral subtype studied among children conflicting findings such that no conclusive relationships between severity established. Methods During 2016–2020, aged &lt;5 years were enrolled prospective...
Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients.We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted the intensive care or high-acuity unit with COVID-19. Using mixed-effects models, we assessed odds death requiring life support for COVID-19 after adjustment age, sex, race Hispanic origin, underlying conditions...
Abstract Background Multisystem inflammatory syndrome in children (MIS‐C) is a rare but serious complication of severe acute respiratory coronavirus 2 infection. Features MIS‐C overlap with those Kawasaki disease (KD). Objective The study objective was to develop prediction model assist this diagnostic dilemma. Methods Data from retrospective cohort hospitalized KD before the 2019 pandemic were compared prospective MIS‐C. A bootstrapped backwards selection process used logistic regression...
OBJECTIVE Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity critical for assessing future interventions. We used data from a large, prospective surveillance study to assess risk factors associated with severe presentation using modified Vesikari score (MVS) and Clark (CS) severity. METHODS From December 1, 2012 June 30, 2016, AGE was performed between 15 days 17 years old emergency, inpatient, outpatient settings...
Asthma and allergic rhinitis are respiratory diseases with a significant global burden. Forkhead box O3 (FOXO3) is gene involved in the etiology of number diseases. The objective this study to assess association rs13217795, an intronic FOXO3 single-nucleotide polymorphism, asthma rhinitis. In case–case–control genetic study, genotyping was conducted using PCR–RFLP method. Genotype-based associations were investigated under general, recessive, dominant models disease penetrance binomial...
Abstract Accurate molecular diagnostic tests are necessary for confirming a diagnosis of coronavirus disease 2019 (COVID-19) and identifying asymptomatic carriage severe acute respiratory syndrome 2 (SARS-CoV-2). The number available SARS-CoV-2 nucleic acid detection continues to increase as does the COVID-19 literature. Thus, Infectious Diseases Society America (IDSA) developed an evidence-based guideline assist clinicians, clinical laboratorians, patients, policymakers in decisions related...
The foramen magnum is morphometrically typified by two perpendicular diameters and a distinct margin. This important anatomical landmark subject to high interindividual variation. objective of this study was evaluate the dimensions morphology in Jordanian population. In retrospective study, 247 individuals were consecutively sampled using institutional picture archiving communication system. anteroposterior transverse measured; index calculated; and, shape visually assessed. sex-pooled 35.1...
Pediatric hematopoietic cell transplant (HCT) recipients exhibit poor serologic responses to influenza vaccination early after transplant. To facilitate the optimization of timing, we sought identify B- and T-cell subpopulations associated with vaccine immunogenicity in this population. We used mass cytometry phenotype peripheral blood mononuclear cells collected from pediatric HCT enrolled a multicenter trial comparing high- standard-dose formulations over 3 seasons (2016-2019). fit linear...