Jaycee Jumarang
A5010515669- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- Congenital Diaphragmatic Hernia Studies
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Ultrasound in Clinical Applications
- Inhalation and Respiratory Drug Delivery
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Pregnancy and Medication Impact
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
University of California, San Diego
2023-2025
Children's Hospital of Los Angeles
2020-2023
University of Southern California
2021
Testing efforts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been burdened by the scarcity of testing materials and personal protective equipment health care workers. The simple painless process saliva collection allows widespread testing, but enthusiasm is hampered variable performance compared to that nasopharyngeal swab (NPS) samples. We prospectively collected paired NPS samples from a total 300 unique adult pediatric patients. SARS-CoV-2 RNA was detected in...
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 and adults to define their circulating SARS-CoV-2-specific CD4
Importance Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide. Objective To evaluate characteristics outcomes RSV-related critical illness in US infants during peak 2022 RSV transmission. Design, Setting, Participants This cross-sectional study used a public health prospective surveillance registry 39 pediatric hospitals across 27 states. were admitted for 24 or more hours between October 17 December 16,...
Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming Network conducted a case-control study March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt vaccine dose (vaccine [VE]) hospitalization in infants and subset <3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all Case-patients (infants hospitalized outside...
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated vaccines.During December 19, 2021-October 29, 2023, Overcoming Network evaluated effectiveness (VE) ≥2 mRNA doses against hospitalization and critical illness among U.S. children adolescents aged 5-18 years, using a case-control design.Too...
Objectives: Studies of household transmission severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) focused on households with children are limited. We investigated secondary attack rate (SAR), dynamics, and contributing factors in children. Materials Methods: In this prospective case-ascertained study Los Angeles County, California, all members were enrolled if ≥1 member tested positive for SARS-CoV-2 by polymerase chain reaction (PCR). Nasopharyngeal PCRs, serology, symptom data...
Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined immune responses to in unvaccinated pregnant and nonpregnant women acute convalescent COVID-19, quantifying 217 parameters. Humoral were similar women, although our systems serology approach revealed distinct antibody FcγR profiles between women. Cellular analyses demonstrated marked differences NK cell unconventional T...
Pediatric respiratory syncytial virus (RSV)-related acute lower tract infection (LRTI) commonly requires hospitalization. The Clinical Progression Scale Pediatrics (CPS-Ped) measures level of support and degree hypoxia across a range disease severity, but it has not been applied in infants hospitalized with severe RSV-LRTI. We analyzed data from prospective surveillance registry for RSV-related complications 39 U.S. PICUs October through December 2022. assigned CPS-Ped (0=discharged home at...
Abstract Background Mucosal immunity may contribute to clearing SARS-CoV-2 infection prior systemic infection. We describe detection of specific nasal mucosal antibodies in a group exposed household individuals that evaded and remained seronegative.Figure 1.SARS-CoV-2-specific SIgA. SARS-CoV-2-specific SIgA control participants (A). Positive thresholds 0.20 6.30 AU/mL were calculated for unadjusted adjusted SIgA, respectively, based on mean + 3 standard deviation the samples. Exposed...
Abstract Background SARS-CoV-2-specific mucosal antibodies inhibit viral replication and infection within the upper respiratory tract. We investigated nasal secretory IgA (SIgA) induction differences by exposure history protection against subsequent infection. Visual schematic of groups. Methods Between June 2020 February 2024, nasopharyngeal swab (NPS) samples were collected 14-89 days following recent or vaccination. SIgA adjusted for total (SIgAadj) neutralization activity measured using...
Abstract Background Age and obesity status are associated with severe outcomes among hospitalized individuals COVID‐19. It remains unclear whether age risk factors for milder COVID‐19 illness. Methods We prospectively enrolled SARS‐CoV‐2‐exposed individuals. Participants recorded symptoms 28 days were tested SARS‐CoV‐2 by reverse transcription polymerase chain reaction (RT‐PCR) serology. Type, number, duration of laboratory parameters compared status. Results Of 552 from June 2020 to January...
Abstract Testing efforts for SARS-CoV-2 have been burdened by the scarcity of testing materials and personal protective equipment healthcare workers. The simple painless process saliva collection allows widespread testing, but enthusiasm is hampered variable performance compared to nasopharyngeal swab (NPS) samples. We prospectively collected paired NPS samples from a total 300 unique adult pediatric patients. RNA was detected in 32.2% (97/300) individuals using TaqPath COVID-19 Combo Kit...
Abstract Background Characterization of longitudinal SARS-CoV-2-specific antibody responses in children following infection and vaccination is needed to inform SARS-CoV-2 vaccine policy decisions for children, which may differ from adults. Methods We enrolled individuals at the time or serological testing compared SARS-CoV-2-spike-specific IgG neutralization activity adults stratified by status using enzyme-linked immunosorbent virus assays. Results Between June 2020 December 2022, we...
Longitudinal data comparing SARS-CoV-2 serology in individuals following infection and vaccination over 12 months are limited. This study compared the magnitude, decay, variability serum IgG, IgA, neutralizing activity induced by natural (n = 218) or mRNA naïve 143) experienced 122) time using enzyme-linked immunosorbent assays an vitro virus neutralization assay. Serological responses were found to be highly variable after with but durable through months. Antibody levels vaccinated, peaked...
Mucosal immunity may contribute to clearing SARS-CoV-2 infection prior systemic infection, thereby allowing hosts remain seronegative. We describe the meaningful detection of SARS-CoV-2-specific nasal mucosal antibodies in a group exposed-household individuals that evaded infection. Between June 2020 and February 2023, nasopharyngeal swab (NPS) acute convalescent blood were collected from exposed SARS-CoV-2-confirmed household member. Nasal secretory IgA (SIgA) targeting spike protein...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants demonstrate predilection for different regions of the tract. While saliva-based reverse transcription-polymerase chain reaction (RT-PCR) testing is a convenient, cost-effective alternative to nasopharyngeal swabs (NPS), few studies date have investigated whether saliva sensitivity differs across concern. Methods SARS-CoV-2 RT-PCR was performed on paired NPS and specimens collected from individuals with...
Background: Household transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) significantly contributes to increased community cases. Methods: We conducted a prospective case-ascertained study investigate the household secondary attack rate (SAR) and contributing factors in urban Los Angeles, California, USA. members were enrolled prospectively if ≥1 member tested positive for SARS-CoV-2 by polymerase chain reaction (PCR). Nasopharyngeal swabs PCR symptom data obtained...