Cindy Bowens
A5072247378- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- COVID-19 Impact on Reproduction
- Respiratory Support and Mechanisms
- Patient Safety and Medication Errors
- Long-Term Effects of COVID-19
- Central Venous Catheters and Hemodialysis
- Vaccine Coverage and Hesitancy
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pneumonia and Respiratory Infections
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Nosocomial Infections in ICU
- Anesthesia and Sedative Agents
- Viral gastroenteritis research and epidemiology
- COVID-19 and Mental Health
- Palliative Care and End-of-Life Issues
- Organ Donation and Transplantation
The University of Texas Southwestern Medical Center
2010-2024
Children's Medical Center
2017-2024
Southwestern Medical Center
2020-2023
University of Louisville
2021
Norton Hospital
2021
Kosair Children's Hospital
2021
Weatherford College
2020
Karolinska Institutet
2020
Saud Al-babtain Cardiac Centre
2020
All India Institute of Medical Sciences
2020
<h3>Importance</h3> Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes. <h3>Objective</h3> To compare clinical characteristics and outcomes adolescents with MIS-C vs those severe coronavirus disease 2019 (COVID-19). <h3>Setting, Design, Participants</h3> Case series 1116 patients aged younger than 21 years hospitalized between March 15 October 31, 2020, at 66 US hospitals 31 states. Final date follow-up was January...
Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement children and adolescents is unclear.To understand range severity among associated with COVID-19.Case series patients (age <21 years) hospitalized between March 15, 2020, December positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals Overcoming COVID-19 public health...
Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious hyperinflammatory condition, which generally occurs 2-6 weeks after typically mild or asymptomatic infection with SARS-CoV-2, the virus that causes COVID-19 (1-3). In United States, BNT162b2 (Pfizer-BioNTech) vaccine currently authorized for use and adolescents aged 5-15 years under an Emergency Use Authorization fully licensed by Food Drug Administration persons ≥16 (4). Prelicensure randomized trials ≥5...
COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or might become in the future, protect them from COVID-19.§ Infants at risk life-threatening complications COVID-19, including acute respiratory failure (1). Evidence other vaccine-preventable diseases suggests that maternal immunization can provide protection infants, especially during high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent...
Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood.In a multicenter, case-control, public health investigation ages 5-18 years hospitalized from 1 July 2021 7 April 2022, we compared the odds being fully vaccinated (2 doses BNT162b2 vaccine ≥28 days...
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated vaccines.During December 19, 2021-October 29, 2023, Overcoming Network evaluated effectiveness (VE) ≥2 mRNA doses against hospitalization and critical illness among U.S. children adolescents aged 5-18 years, using a case-control design.Too...
Coinfection with influenza virus and methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening necrotizing pneumonia in children. Sporadic incidence precludes evaluation of antimicrobial efficacy. We assessed the clinical characteristics outcomes critically ill children influenza-MRSA evaluated antibiotic use.We enrolled (<18 years) infection respiratory failure across 34 pediatric intensive care units 11/2008-5/2016. compared baseline characteristics, courses, therapies...
Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia.We performed unsupervised clustering on data from 1,526 (684 labeled MIS-C by clinicians) <21 years old hospitalized COVID-19-related illness admitted between 15 March 2020 31 December 2020. We compared prevalence of assigned labels clinical features among clusters, followed recursive feature elimination to identify...
To compare the efficacy of a low-dose methadone tapering schedule to high-dose in pediatric intensive care unit patients exposed infusions fentanyl, with or without midazolam, for ≥ 5 days.Prospective, double-blind, randomized trial.Pediatric tertiary children's hospital.Seventy-eight patients, 74 whom had been receiving both fentanyl and were randomized. Forty-one group 37 group. Sixty successfully completed trial, 34 group, 26 group.Patients receive either at starting dose 0.1 mg/kg/dose...
Importance In 2020 during the COVID-19 pandemic, neurologic involvement was common in children and adolescents hospitalized United States for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related complications. Objective To provide an update on spectrum of SARS-CoV-2–related among 2021. Design, Setting, Participants Case series investigation patients reported to public health surveillance with illness between December 15, 2020, 31, 2021, 55 US hospitals 31 states follow-up at...
Patients who survive pediatric critical illness and their caregivers commonly experience physical, emotional, cognitive sequelae. However, the rate duration of school absence among patients work are unknown.To determine rates children survived hospitalization with acute respiratory failure caregivers.The Randomized Evaluation Sedation Titration for Respiratory Failure (RESTORE) cluster randomized trial included 2449 from 31 sites to protocolized sedation (intervention) vs usual care...
Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients.We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted the intensive care or high-acuity unit with COVID-19. Using mixed-effects models, we assessed odds death requiring life support for COVID-19 after adjustment age, sex, race Hispanic origin, underlying conditions...
Acute respiratory failure (ARF) can progress to acute distress syndrome and death. Biomarkers may allow for risk stratification prognostic enrichment in ARF. Thrombomodulin (TM) is a transmembrane antithrombotic mediator expressed endothelial cells. It cleaved into its soluble form (sTM) during inflammation vascular injury. Levels of sTM correlate with end organ dysfunction.This was prospective observational study 432 patients aged 2 weeks-17 years requiring invasive mechanical ventilation....
Background and objectives: In June 2022, the mRNA COVID-19 vaccination was recommended for young children. We examined clinical characteristics factors associated with status among vaccine-eligible children hospitalized acute COVID-19. Methods: enrolled inpatients 8 months to <5 years of age community-acquired across 28 US pediatric hospitals from September 20, 2022 May 31, 2023. assessed demographic factors, including highest level respiratory support, defined as unvaccinated,...
Rationale: Racial disparities in pain management have been previously reported for children receiving emergency care.Objectives: To determine whether patient race or ethnicity is associated with the broader goal of and sedation among pediatric patients mechanically ventilated acute respiratory failure.Methods: Planned secondary analysis RESTORE (Randomized Evaluation Sedation Titration Respiratory Failure). RESTORE, a cluster-randomized clinical trial conducted 31 U.S. intensive care units,...
The American Heart Association (AHA) and other national institutions have endorsed modifications to resuscitation guidelines given the risk of healthcare workers' (HCWs) exposure COVID-19. Institutional implementation COVID-19-focused requires both proof feasibility education HCW. Pediatric critical care medical directors at University Texas Southwestern/Children's Health System (UTSW/CHST) created a guideline for COVID-19 patients. simulation team used in situ demonstrate create educational...
Children are vulnerable to medical errors. Adverse events leveraged as educational tools in Morbidity and Mortality (M&M) Conference. Traditionally, M&M has brought angst when discussing adverse events. Our goal was transition an environment highlighting system failures. A survey created capture data on satisfaction, education, process improvement. Feedback from the surveys led several changes, including fostering a multidisciplinary forum, prioritizing topics, emphasizing In 5...