A5034033911- Congenital Heart Disease Studies
- Radiopharmaceutical Chemistry and Applications
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Prostate Cancer Treatment and Research
- Influenza Virus Research Studies
- Science, Research, and Medicine
- Turbomachinery Performance and Optimization
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Transplantation: Methods and Outcomes
- Fluid Dynamics and Turbulent Flows
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Vaccine Coverage and Hesitancy
- Combustion and flame dynamics
- Estrogen and related hormone effects
- Chemical Reactions and Isotopes
- Cancer therapeutics and mechanisms
- Cardiac Arrhythmias and Treatments
- SARS-CoV-2 and COVID-19 Research
- Radiation Effects and Dosimetry
- Oral health in cancer treatment
Medical University of South Carolina
2020-2023
Creative Commons
2020
Virginia Tech
2017-2018
University of Nebraska Medical Center
2011-2014
Targeted molecular radiotherapy opens unprecedented opportunities to eradicate cancer cells with minimal irradiation of normal tissues. Described in this study are radioactive cyclosaligenyl monophosphates designed deliver lethal doses radiation cells. These compounds can be radiolabeled SPECT- and PET-compatible radionuclides as well suitable for Auger electron therapies. This characteristic provides an avenue the personalized comprehensive treatment strategy that comprises diagnostic...
Background and objectives: In June 2022, the mRNA COVID-19 vaccination was recommended for young children. We examined clinical characteristics factors associated with status among vaccine-eligible children hospitalized acute COVID-19. Methods: enrolled inpatients 8 months to <5 years of age community-acquired across 28 US pediatric hospitals from September 20, 2022 May 31, 2023. assessed demographic factors, including highest level respiratory support, defined as unvaccinated,...
BACKGROUND The androgen receptor (AR) plays a dominant role in the pathogenesis of prostate cancer. 5-Radioiodo-3′-O-(17β-succinyl-5α-androstan-3-one)-2′-deoxyuridin-5′-yl phosphate (RISAD-P) is an AR-targeting reagent developed for noninvasive assessment AR and proliferative status AR-expressing tumors, molecular radiotherapy with Auger electron-emitting radionuclides. In this study, preclinical toxicity targeting potential RISAD-P was evaluated. METHODS Effects nonradioactive ISAD-P...
Pancreatic cancer does not respond to a single-agent imatinib therapy. Consequently, multimodality treatments are contemplated. Published data indicate that in colorectal cancer, and radioimmunotherapy synergize delay tumor growth. In pancreatic the response is additive. This disparity of outcomes merited further studies because interactions between these modalities depend on imatinib-induced reduction interstitial fluid pressure. The examination human murine PDGFr-β/PDGF-B pathways SW1990...
Currently, the surgical procedure followed by majority of cardiac surgeons to address right ventricular dysfunction is Fontan procedure, which connects superior vena cava and inferior (IVC) directly left pulmonary arteries (LPA RPA, respectively) bypassing atrium. The goal this study develop a patient-specific four-way connector bypass dysfunctional ventricle augment circulation. was intended channel blood flow from RPA LPA. By creating with proper hemodynamic characteristics, one can...
Hypoplastic Right Heart Syndrome is a type of congenital heart defect where the right ventricle underdeveloped in an infant to pump blood from body lungs. The three-staged surgical Fontan procedure provides temporary treatment; however, most cases, transplantation required due postoperative complications. Currently, there are no devices commercially available market provide therapeutic assistance these patients until donor available. Thus, novel dual propeller concept developed cavopulmonary...
Currently, the surgical procedure followed by majority of cardiac surgeons to address right ventricular dysfunction is Fontan procedure, which connects superior and inferior vena cava directly left pulmonary arteries bypassing atrium. However, this not most efficient configuration from a hemodynamics perspective. The goal study develop patient-specific 4-way connector bypass dysfunctional ventricle augment circulation. intended channel blood flow arteries. By creating with proper hemodynamic...
With highly integrated airframe architectures emerging as the leading concept of next generation aviation vehicles, research is needed to understand interactions between inlet swirl distortions and turbofan engines. To meet these demands, a computational fluid dynamics investigation was conducted monitor streamwise development complex swirling velocity field in duct engine with without presence nose cone component. By modeling two geometric setups, natural forced fluid/nose were...
The most common surgical procedure used to treat right ventricular heart failure is the Fontan procedure, which connects superior vena cava and inferior directly left pulmonary arteries bypassing atrium. Many studies have been performed improve procedure. Research has done on a four-way connector that can both passively actively flow characteristics of junction between Superior Vena Cava (SVC), Inferior (IVC), Left Pulmonary Artery (LPA) Right (RPA), using an optimized dual propeller system....
Background: Pediatric hematology/oncology patients are at high risk for CLABSIs due to immunosuppression, device utilization, and mucosal barrier injury related chemotherapy. Objectives: We aim achieve 90% compliance with adjunct CLABSI prevention bundles (daily care, oral environmental care) in the pediatric population reduce CLABSI. Methods: began a series of plan-do-study-act cycles aimed improving oncology patients. In October 2016, our quality team monthly meetings bedside nurse...