A5059374251- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Acute Lymphoblastic Leukemia research
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- Brain Metastases and Treatment
- Adrenal and Paraganglionic Tumors
- Trauma and Emergency Care Studies
- Multiple and Secondary Primary Cancers
- Carcinogens and Genotoxicity Assessment
- Hearing, Cochlea, Tinnitus, Genetics
- Prenatal Screening and Diagnostics
- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
King Hussein Cancer Center
2015-2025
University of Toronto
2017
University of California, San Francisco
2017
Jordan Hospital
2002-2011
King Hussein Medical Center
2007-2011
University of Jordan
2007-2009
Neurology, Inc
2001
Hospital for Sick Children
1998
Biallelic mismatch repair deficiency (bMMRD) is a cancer predisposition syndrome affecting primarily individuals from consanguinous families resulting in multiple childhood cancers including high grade gliomas (HGG). This the first study to assess prevalence of bMMRD among patients with HGG countries where consanguinity high. We collected molecular and clinical information on all children diagnosed supratentorial primitive neuroectodermal tumors (sPNET) between 2003 2013 at King Hussein...
Telemedicine is widely used in industrialized countries for educational purposes. Twinning experiences using telemedicine between institutions and developing (DC) have been limited. Pediatric neuro-oncology a complex multidisciplinary discipline that underserved most of DC provides model to test the feasibility such tool twinning purposes.A computer, an EMLO visual presenter HV-7600SX document camera, TANDBERG 6000 videoconference unit were present data. For connectivity, we six-channel ISDN...
Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as single entity when assessing CMS risk; however, recent studies highlighting their clinical heterogeneity suggest the need subgroup-specific analysis. Here, we examine large international multicenter cohort molecularly characterized medulloblastoma patients to assess predictors...
Primary central nervous system (CNS) tumors are often associated with relatively poor outcomes. Data on the epidemiology and outcome of CNS in Jordan scarce. We aim to report primary patients managed at a comprehensive cancer care center Jordan. performed retrospective chart review all Jordanian tumor diagnosis who were between July 2003 June 2019. included entities described 2021 WHO classification system, addition pituitary neuroendocrine (PitNETs). used Kaplan-Meier method estimate...
Abstract Successful twinning initiatives have been reported in childhood leukemia. Pediatric neuro‐oncology requires a complex multidisciplinary approach and the feasibility of similar programs is unknown. Twinning between King Hussein Cancer Center Amman Hospital for Sick Children Toronto started with e‐mail communications, subsequently included monthly videoconferences exchanges institutions. The outcome 35 newly diagnosed medulloblastoma patients (22 high‐risk 13 average‐risk) treated...
The management of central nervous system tumors is challenging in low- and middle-income countries. Little known about applicability twinning initiatives with high-income countries neuro-oncology. In 2004, a monthly neuro-oncology video-teleconference program was started between King Hussein Cancer Center (Amman, Jordan) the Hospital for Sick Children (Toronto, Ontario, Canada). More than 100 conferences were held > 400 cases discussed. aim this work to assess sustainability such an...
Pleomorphic xanthoastrocytoma is a rare brain tumor with unique high frequency of BRAF V600E mutation which plausible for targeted therapy. The anaplastic variant has generally worse prognosis. We present an adolescent patient disseminated relapse pleomorphic following surgery, radiotherapy, and chemotherapy. She had dramatic prolonged response to inhibitor (Dabrafinib) later addition MEK (Trametinib) on progression. With minimal side effects good quality life, the alive more than 2 years...
PURPOSE Medulloblastoma is composed of four clinically and prognostically distinct molecular subgroups (WNT, SHH, group 3, 4). However, the clinical implications these in context unique challenges low- to middle-income countries are rarely reported. METHODS We assembled an institutional cohort children (3-18 years) diagnosed with medulloblastoma treated Jordan between 2003 2016. Tumors were subgrouped by NanoString correlated radiologic characteristics. RESULTS Eighty-eight patients...
Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is an increasingly recognized entity that belongs to the family of embryonal tumors CNS. The authors present three cases this rare were encountered at King Hussein Cancer Center, Amman, Jordan. Discussion clinicopathological findings presented along a recent literature review. Sixteen-, 57- 30-month-old children located in pineal gland, right fronto- parieto-temporal region cerebellum, respectively. hypocellular as well...
Abstract Pediatric craniopharyngioma is a rare tumor with excellent survival but significant long‐term morbidities due to the loco‐regional growth or secondary its treatment. Visual impairment, panhypopituitarism, hypothalamic damage, and behavioral changes are among main challenges. This should be managed under care of multidisciplinary team determine optimum treatment within available resources. particularly important for low middle‐income countries where resources variable. report...
Corpus callosotomy is an effective neurosurgical procedure for children with intractable atonic or drop attack seizures. While this has not changed significantly over the past three decades, some technical issues remain to be resolved. These include intraoperative determination of extent callosotomy, need stage procedure, as well side approach craniotomy. We report our 8-year experience corpus using a frameless stereotactic image-guided system (ISG Viewing Wand<sup>®</sup>)....
Introduction Advances in molecular diagnostics led to improved targeted interventions the treatment of pediatric CNS tumors. However, capacity test for these is limited LMICs, and thus their value needs exploration. Methods We reviewed our experience with NGS testing (TruSight RNA Pan-Cancer-seq panel) tumors at KHCC/Jordan (March/2022–April/2023). Paraffin blocks’ scrolls were shipped SickKids laboratory based on multidisciplinary clinic (MDC) recommendations. patients’ characteristics,...
Introduction Most pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use low-middle-income-countries (LMICs) are limited. Methods We retrospectively reviewed our Jordanian experience of compassionate inhibitors treating children with gliomas. patients’ clinical characteristics, response, side effects. Results Twenty patients (13 males,...
Cerebellar involvement in tuberous sclerosis is rare and generally nonsymptomatic. The authors describe a cerebellar tuber 5-year-old boy with sclerosis. A CT scan at age 2 years showed the characteristic cortical, white matter, subependymal lesions of At 5 years, when patient was symptomatic ataxia, MRI scans revealed additionally presence right enhancing lesion edema. total surgical resection undertaken. very firm demonstrated marked disorganization neuronal architecture folia, bizzare...
Pediatric intracranial germ cell tumors (iGCT) are rare, with limited data available from Arabic countries.We retrospectively reviewed the medical charts of children <18 years diagnosed iGCT at King Hussein Cancer Center/Jordan (January 2003 to December 2020) for clinical characteristics, treatment, and morbidities.Sixteen patients had germinoma; median age was 6.9 symptoms duration 8 months. Nine were suprasellar, five pineal, two bifocal. Four metastatic. Eight slightly elevated beta...
The authors report the case of 5-year-old girl who presented with 4 episodes recurrent meningitis. Her initial workup revealed a lumbosacral dermoid sinus associated diastematomyelia and tethered cord. Therefore, surgical repair to correct anomaly was performed. However, another episode meningitis occurred after surgery, subsequent temporal bone scan presence left Mondini dysplasia. To authors’ knowledge, this is first dysplasia in association diastematomyelia.
We report a 28-month-old male child, known to have Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI), who presented with inconsistent right hand discomfort. Clinical suspicion of carpal tunnel was confirmed by nerve conduction and electromyographic studies, decompressive procedure done uneventful recovery. Carpal in mucopolysaccharidosis patients should be suspected, diagnosed treated early for better outcome.