A5103113175- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- MRI in cancer diagnosis
- Acute Lymphoblastic Leukemia research
- Protein Degradation and Inhibitors
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Chromatin Remodeling and Cancer
- Ocular Oncology and Treatments
- Hedgehog Signaling Pathway Studies
- Fetal and Pediatric Neurological Disorders
- Pain Management and Opioid Use
- Pain Management and Placebo Effect
- Pituitary Gland Disorders and Treatments
- Atomic and Subatomic Physics Research
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Adrenal and Paraganglionic Tumors
- Prenatal Screening and Diagnostics
- Testicular diseases and treatments
- Pediatric Pain Management Techniques
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- PI3K/AKT/mTOR signaling in cancer
Newcastle University
2015-2025
Great North Children's Hospital
2019-2025
University of Newcastle Australia
2025
University Hospital of Geneva
2024
University of Geneva
2024
Royal Victoria Infirmary
2016-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018-2024
Yahoo (United Kingdom)
2020
Abstract Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency of Tumor Immune Microenvironment (TIME) likely to predict patient response. Here, we describe TIME >6000 primarily pediatric CNS using a deconvolution (methylCIBERSORT). We produce validate custom reference signature defining 11 non-cancer cell types estimate relative proportions infiltration in panCNS tumor cohort spanning 80 subtypes. group...
Abstract BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 ( n = 77) of ongoing phase 2 FIREFLY-1 (PNOC026) trial investigated efficacy oral, selective, central nervous system–penetrant, type II RAF inhibitor tovorafenib (420 mg m − once weekly; 600 maximum) patients with -altered, relapsed/refractory pLGG. 60) is an extension cohort, which provided treatment access for -altered pLGG after arm closure. Based on independent review,...
Abstract Many children with cancer in low‐ and middle‐income countries are treated hospitals lacking key infrastructure, including diagnostic capabilities, imaging modalities, treatment components, supportive care, personnel. Childhood regimens adapted to local conditions provide an opportunity cure as many possible the available resources, while working improve services care. This paper from Adapted Treatment Regimens Working Group of Pediatric Oncology Developing Countries committee...
Abstract To determine if apparent diffusion coefficients (ADC) can discriminate between posterior fossa brain tumours on a multicentre basis. A total of 124 paediatric patients with (including 55 Medulloblastomas, 36 Pilocytic Astrocytomas and 26 Ependymomas) were scanned using weighted imaging across 12 different hospitals 18 scanners. Apparent coefficient maps produced histogram data was extracted from tumour regions interest. Total histograms metrics (mean, variance, skew, kurtosis 10th,...
BackgroundMedulloblastoma patients with a sub-total surgical resection (STR; >1.5 cm2 primary tumour residuum post-surgery) typically receive intensified treatment. However, the association of STR poor outcomes has not been observed consistently, questioning validity as high-risk disease feature.MethodsWe collected extent (EOR) data from 1110 (from UK CCLG centres (n = 416, between September 1990 and July 2014) published 694) cohorts), largest cohort molecularly clinically annotated tumours...
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance playing key role in providing tumour specific information. Diffusion weighted perfusion are commonly used to aid the non-invasive children's tumours, but usually evaluated by expert qualitative review. Quantitative studies mainly single centre modality. aim this work was combine multi-centre diffusion imaging, machine learning, develop learning based...
Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood (iMB) has no standard care at relapse. This work aimed to evaluate post-relapse survival (PRS) explore prognostic factors patients with nodular desmoplastic (ND) and/or SHH iMB. international retrospective study included 147 subjects diagnosed relapsed Nodular Desmoplastic/SHH iMB between 1995 2017, < 6 years old original diagnosis, treated without initial craniospinal irradiation (CSI)....
Abstract Brain tumors represent the highest cause of mortality in pediatric oncological population. Diagnosis is commonly performed with magnetic resonance imaging. Survival biomarkers are challenging to identify due relatively low numbers individual tumor types. 69 children biopsy-confirmed brain were recruited into this study. All participants had perfusion and diffusion weighted imaging at diagnosis. Imaging data processed using conventional methods, a Bayesian survival analysis...
FOXO1 has an oncogenic role in adult germinal center-derived lymphomas, which mutations, predominately within the AKT recognition motif, cause nuclear retention of FOXO1, resulting increased cell proliferation. To determine prevalence and distribution mutations pediatric Burkitt lymphoma (BL), we sequenced a large number sporadic endemic BL patient samples. We report high frequency both at diagnosis, occurring 23/78 (29%) 48/89 (54%) samples, respectively, as well 8/16 (50%) cases relapse....
The WHO Global Initiative for Childhood Cancer aims to increase survival at least 60% all children with cancer globally, initial focus on six common curable types. Frequent causes of treatment failure in low income countries (LICs) are abandonment and death during treatment. Here, we report the outcome end patients newly diagnosed types, admitted Queen Elizabeth Central Hospital, Blantyre, Malawi.Outcome was documented analyzed retrospectively a working diagnosis type (ALL, Hodgkin disease,...
Abstract Group 4 tumours (MB Grp4 ) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MB molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), however their inter-relationships and potential to improve sub-classification risk-stratification remain undefined. We comprehensively characterised paediatric landscape determined its utility management. A clinically-annotated discovery cohort...
10004 Background: Pediatric low-grade gliomas (LGGs) are the most common brain tumors of childhood. Genomic alterations BRAF ( KIAA1549-BRAF fusions, 50–60% and V600E mutations, 5–15%) frequent oncogenic drivers in pLGGs. Tovorafenib is an investigational, oral, selective, brain-penetrant, small molecule, type II pan-RAF inhibitor. has demonstrated clinically meaningful responses 24/35 patients (2 CR, 7 PR 15 SD) pediatric phase 1B PNOC014 (NCT03429803) trial with RAF-altered cancers...
Abstract Background The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. Methods We conducted multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical (epi-)genetic characterization. Results Median overall survival (OS) was 15.5 months (interquartile range, 10.9–27.7) 2-year rate 28%. Histopathological grading correlated...
Abstract Pediatric craniopharyngioma is a rare tumor with excellent survival but significant long‐term morbidities due to the loco‐regional growth or secondary its treatment. Visual impairment, panhypopituitarism, hypothalamic damage, and behavioral changes are among main challenges. This should be managed under care of multidisciplinary team determine optimum treatment within available resources. particularly important for low middle‐income countries where resources variable. report...
MRS can provide high accuracy in the diagnosis of childhood brain tumours when combined with machine learning. A feature selection method such as principal component analysis is commonly used to reduce dimensionality metabolite profiles prior classification. However, an alternative approach identifying optimal set metabolites has not been fully evaluated, possibly due challenges defining this for a multi-class problem. This study aims investigate from vivo tumour Multi-site 1.5 T and 3...
Infant and young childhood medulloblastoma (iMB) is usually treated without craniospinal irradiation (CSI) to avoid neurocognitive late effects. Unfortunately, many children relapse. The purpose of this study was assess salvage strategies prognostic features patients with iMB who relapse after CSI-sparing therapy.