A5049469167- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Family and Disability Support Research
- Chromatin Remodeling and Cancer
- Brain Tumor Detection and Classification
- Meningioma and schwannoma management
- Family Support in Illness
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
- Cancer-related cognitive impairment studies
- Cancer Research and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurofibromatosis and Schwannoma Cases
- Antibiotics Pharmacokinetics and Efficacy
- Neuroendocrine Tumor Research Advances
- Hedgehog Signaling Pathway Studies
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
Cincinnati Children's Hospital Medical Center
2014-2024
Nationwide Children's Hospital
2020-2024
University of Southern California
2024
Case Western Reserve University
2024
The Ohio State University
2021-2024
Hospital for Sick Children
2022
SickKids Foundation
2022
University of Toronto
1991-2022
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2022
University of Cincinnati
2019-2021
Diffuse intrinsic pontine glioma (DIPG) and midline high-grade (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but not comprehensively characterized pediatric HGG. We performed whole exome sequencing on 38-matched primary, contiguous, metastatic tumor sites from eight children with DIPG (n = 7) or mHGG 1) collected using a unique MRI-guided autopsy protocol. Validation was Sanger sequencing, Droplet Digital polymerase-chain...
Treatment of medulloblastoma has evolved from surgery and radiotherapy to contemporary multimodal regimens. However, the impact on long-term health outcomes remains unknown.Cumulative incidence late mortality (5 or more years diagnosis), subsequent neoplasms (SNs), chronic conditions were evaluated in Childhood Cancer Survivor Study among 5-year survivors diagnosed between 1970 1999. Outcomes by treatment exposure, including historical therapy (craniospinal irradiation [CSI] ≥ 30 Gy, no...
Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation involving predominantly the skin and gastrointestinal tract. Traditional treatment modalities include corticosteroids, interferon-α, sclerotherapy, aggressive surgical resection. Sirolimus has been used in several single case reports.We performed single-institution retrospective review of four children with BRBNS, who received sirolimus as part their regimens. A diagnosis BRBNS was based on clinical, radiologic,...
Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use targeted therapy, especially at progression, is increasingly practiced despite paucity data regarding temporal therapy-driven genomic evolution pHGGs. To study the genetic landscape pHGGs recurrence, we performed whole exome methylation analyses on matched primary recurrent...
Abstract Background The COVID‐19 pandemic has prompted unprecedented challenges, contributing to greater difficulties among families of children with special health care needs, such as pediatric brain tumor survivors. We examined the impact on psychosocial functioning adolescent and emerging adult survivors their parents. hypothesized that disruptions survivor social connectedness would be associated survivor‐reported posttraumatic stress family outcomes, including functioning, parenting,...
Our goal was to examine the feasibility and preliminary efficacy of an app-based coaching intervention (Social Participation Navigation; SPAN) help survivors acquired brain injury attain social participation goals. Research Method/Design: This is a nonrandomized pilot trial SPAN, including 15 adolescents (9 with traumatic injury, 6 tumor) between ages 14-22. The SPAN consisted mobile app support development implementation goals, weekly video-conference sessions identify goals step-by-step...
Central line-associated bloodstream infection (CLABSI) is a known complication of central line use. Salvage infected lines with ethanol lock therapy (ELT) systemic antimicrobials may be an alternative treatment option in children.Retrospective review was performed children CLASBI who underwent short-dwell ELT (70% ethanol, 4- to 25-hour dwell times ≤3 days) from January 1, 2007 July 15, 2009.A total 59 patients, aged 2 months 19 years (mean ± SD = 6.3 6.1 years) 80 episodes CLABSI were...
Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Adult survivors (n = 505; median [minimum-maximum] age, 29 [18-46] years) sibling controls 727; 32 [18-58] from Childhood Cancer Survivor Study completed surveys assessing problems chronic health conditions (CHCs). exposures were categorized as historical (craniospinal...
Abstract Background Although pediatric brain tumor survivors are at high risk for a variety of psychosocial and neurocognitive late effects, there few evidence‐based interventions to address their needs. The purpose this study was test the efficacy an online problem‐solving intervention on improving quality life executive dysfunction among adolescent young adult survivors. Procedure A Survivor's Journey adapted from similar traumatic injuries, involved self‐guided web modules providing...
Abstract Background Anti-inflammatory activities of medicinal plants have largely been attributed to their content sesquiterpene lactones (SLs). SLs are predominantly found in the sunflower family Asteraceae and isolated from many this family, particularly Centaurea . The anti-inflammatory extract ainetensis , a Lebanese endemic plant, active molecule were assessed for potential ant-inflammatory activities. Methods Plant ingredient Salograviolide A (SA), guaianolide, used study. Western...
To develop A Survivor's Journey, a web-based psychosocial intervention for adolescent and young adult (AYA) survivors of pediatric brain tumors (PBTs).Stages development included focus groups with five AYA (ages 16-23 years) six parents to identify needs challenges, as well surveys interviews clinical care providers at survivorship clinic.Concerns reported by survivors, parents, were similar those in the literature, including fatigue, memory deficits, poor mood, health concerns, challenging...
Infant and young childhood medulloblastoma (iMB) is usually treated without craniospinal irradiation (CSI) to avoid neurocognitive late effects. Unfortunately, many children relapse. The purpose of this study was assess salvage strategies prognostic features patients with iMB who relapse after CSI-sparing therapy.
Abstract Background Pediatric brain tumor survivors (PBTS) are at risk of worse quality life (QOL) due to the impact neurotoxic treatments on developing nervous system. Parenting factors such as protectiveness have been linked QOL in childhood cancer generally, but yet be explored for PBTS. We examined whether parenting behaviors moderated association between treatment and Methods PBTS (n = 40; ages 10–25) their caregivers 47) completed measures including warmth (support/connectedness)...
Abstract Recent discoveries have provided valuable insight into the genomic landscape of pediatric low-grade gliomas (LGGs) at diagnosis, facilitating molecularly targeted treatment. However, little is known about their temporal and therapy-related heterogeneity. An adequate understanding evolution LGGs’ profiles over time critically important in guiding decisions therapeutics diagnostic biopsy recurrence. Fluorescence situ hybridization, mutation-specific immunohistochemistry, and/or...