Chantel Cacciotti
A5015824841- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
- Sarcoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Telemedicine and Telehealth Implementation
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- Chemotherapy-induced cardiotoxicity and mitigation
- Ocular Diseases and Behçet’s Syndrome
- Platelet Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Ocular Oncology and Treatments
- Pharmacological Effects and Toxicity Studies
- Family and Disability Support Research
- Hedgehog Signaling Pathway Studies
- Family and Patient Care in Intensive Care Units
- Ethics and Legal Issues in Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Palliative Care and End-of-Life Issues
- Polymer Nanocomposite Synthesis and Irradiation
- Histone Deacetylase Inhibitors Research
London Health Sciences Centre
2021-2025
Western University
2021-2024
Children's Hospital of Western Ontario
2022-2024
Western University of Health Sciences
2024
Australian National University
2024
Harvard University
2024
Rush University Medical Center
2024
Cleveland Clinic
2024
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2020-2023
University of Toronto
2023
Background: Clinical trials of anti-Aβ monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal (CSF) Aβ42/40.However, these measure deposits indirectly incompletely.In contrast, postmortem neuropathologic assessments allow direct investigation treatment effects on brain and many other pathologic features.Methods: From a clinical trial dominantly inherited AD, we measured...
Prompt recognition of a child with cancer predisposition syndrome (CPS) has implications for management, surveillance, genetic counseling, and cascade testing relatives. Diagnosis CPS requires practitioner expertise, access to testing, test result interpretation. This diagnostic process is not accessible in all institutions worldwide, leading missed diagnoses. Advances electronic health technology can facilitate risk assessment.To evaluate the accuracy prediction tool (McGill Interactive...
<div>AbstractPurpose:<p>Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There limited data on the clinical course affected patients.</p>Experimental Design:<p>We conducted an international retrospective cohort study patients with TRK fusion–driven tumors.</p>Results:<p>A total 119 were identified. The median age at time diagnosis was 4.5 years. majority reported to have a histology consistent...
<p>Supplementary Figure S1. Diagram of population patients.</p>
<p>Supplementary Figure S2. A) Hazard ratio for progression or death according to clinical characteristics. B) LGG: Low-grade glioma, HGG: High-grade glioma</p>
<p>Supplementary Data S1. Definition of response, Description response criteria used by sites to evaluate tumor extend resection, resection sites.</p>
Atypical teratoid rhabdoid tumors are rare embryonal of the nervous system mainly seen in very young children with aggressive behavior and dismal prognosis when treated conventional chemotherapy only. More recent multimodal strategies combining, variably, high dose chemotherapy, radiotherapy or intrathecal have led to some stride survival. We present results most clinical trials registry data for patients these approaches survival ranging from 37.1% 88.9%. review current consensus molecular...
Surveillance magnetic resonance imaging (MRI) is routinely used to detect recurrence in pediatric central nervous system (CNS) tumors. The frequency of neuroimaging surveillance varies without a standardized approach. A single-institutional retrospective cohort study evaluated the recurrences. This included 476 patients with majority diagnosed low-grade glioma (LGG) (n=138, 29%), high-grade (HGG) (n=77, 16%), ependymoma (n=70, 15%), or medulloblastoma (n=61, 13%). LGG, HGG, and more commonly...
The majority of emergency department (ED) visits and hospitalizations for patients with sickle cell disease (SCD) are pain related. Adequate timely management may improve quality life prevent worsening morbidities. We conducted a retrospective chart review pediatric SCD seen in the ED, selected by cell–related ICD-9 codes. A total 176 encounters were reviewed from 47 to record ED hospitalization trends. Mean time medication administration was 63 minutes. Patients received combination...
Diffuse intrinsic pontine gliomas (DIPGs) are a leading cause of brain tumor deaths in children. Current standard care includes focal radiation therapy (RT). Despite clinical improvement most patients, the effect is temporary and median survival less than 1 year. The use benefit reirradiation have been reported progressive DIPG, yet standardized approaches lacking. We conducted survey to assess practices for DIPG North America.A 14-question REDCap was disseminated 396 American physicians who...
Infant and young childhood medulloblastoma (iMB) is usually treated without craniospinal irradiation (CSI) to avoid neurocognitive late effects. Unfortunately, many children relapse. The purpose of this study was assess salvage strategies prognostic features patients with iMB who relapse after CSI-sparing therapy.
Children with leukemia commonly receive red blood cell (RBC) transfusions and transfusion-related iron overload (TRIO) is a major complication. However, few studies have evaluated TRIO in children no guidelines for screening exist. This retrospective, observational cohort study acute evaluates the prevalence of its impact on end-organ function.The included 139 patients; 60% standard-risk lymphoblastic (ALL), 32% high-risk (HR) ALL, 9% myeloid (AML). The mean age at diagnosis was 6 years...
Childhood cancer survivors (CCS) are at risk of developing subsequent malignant neoplasms (SMNs) resulting from exposure to prior therapies. CCS with underlying predisposition syndromes additional genetic SMN development. The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) tool identifies children increased likelihood having a syndrome, guiding clinicians through series Yes or No questions that generate recommendation for against evaluation. We evaluated MIPOGG's ability predict...
Introduction Pediatric low-grade gliomas (pLGG) are the most common brain tumor in children and encompass a wide range of histologies. Treatment may pose challenges, especially those incompletely resected or with multiple recurrence progression. Case description We report clinical course girl diagnosed pilocytic astrocytoma profound hydrocephalus at age 12 years treated subtotal resection, vinblastine chemotherapy, focal proton radiotherapy. After radiotherapy increased enhancement...
The treatment of BRAF V600E gliomas with inhibitors (BRAFis) and MEK (MEKis) has been increasingly integrated into clinical practice for pediatric low-grade (PLGGs) high-grade (HGGs). However, some questions remain unanswered, such as the best time to start targeted therapy, duration treatment, discontinuation therapy. Given that no trial able address these critical questions, we developed a Canadian Consensus statement mutated well adolescent young adult (AYA) gliomas.