A5027450588- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Cancer Incidence and Screening
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Global Health and Surgery
- Heart Failure Treatment and Management
- Family and Patient Care in Intensive Care Units
- Advances in Oncology and Radiotherapy
- Neuroblastoma Research and Treatments
- Artificial Intelligence in Healthcare
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Family Support in Illness
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Thyroid Cancer Diagnosis and Treatment
- Global Health Workforce Issues
Public Health Ontario
2018-2024
University of Toronto
2016-2024
Pediatric Oncology Group
2020-2023
3M (United States)
2020
Hospital for Sick Children
2015-2019
Institute for Clinical Evaluative Sciences
2019
Leukemia & Lymphoma Society of Canada
2016
SickKids Foundation
2016
Tawam Hospital
2016
Hyperleukocytosis in children with acute lymphoblastic leukemia (ALL) and myeloid (AML) is associated early morbidity mortality. The benefit from leukapheresis controversial, its complications are not well defined. We analyzed the frequency of ALL AML presenting white blood cell (WBC) count >100 × 10(9)/L, type related to leukapheresis. During a 12-year period, 84 634 (13%) 18 143 (12.5%) patients presented hyperleukocytosis. Leukapheresis was performed 12 patients. median initial WBC 474...
The role of hepatitis C virus (HCV) infection in increasing the risk cardiovascular disease (CVD) is controversial. objective present study to estimate 10-year CVD HCV- positive subjects and describe their profile cardiometabolic markers compared HCV-negative subjects. We conducted a cross-sectional risk, calculated using Framingham Risk Score (FRS), participants from Canadian Health Measures Survey (CHMS; 2007–2015, n = 10,115) US-National Nutrition Examination (NHANES; 2007–2016, 16,668)....
Due to the long-term sequelae of cranial radiotherapy (CRT), contemporary treatment protocols for children with acute lymphoblastic leukemia (ALL) aim limit use prophylactic CRT. For patients central nervous system (CNS) involvement ALL at diagnosis, CRT remains common. Children <5 years age are a particularly challenging subgroup in whom consequences can be devastating.This study retrospectively describes overall (OS) and event-free survival (EFS) young (1-5 years) who were treated...
Childhood cancer survivors (CCS) are at risk of developing subsequent malignant neoplasms (SMNs) resulting from exposure to prior therapies. CCS with underlying predisposition syndromes additional genetic SMN development. The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) tool identifies children increased likelihood having a syndrome, guiding clinicians through series Yes or No questions that generate recommendation for against evaluation. We evaluated MIPOGG's ability predict...
Objectives The present study evaluates the extent of association between hepatitis C virus (HCV) infection and cardiovascular disease (CVD) risk identifies factors mediating this relationship using Bayesian network (BN) analysis. Design setting A population-based cross-sectional survey in Canada. Participants Adults from Canadian Health Measures Survey ( n =10 115) aged 30 to 74 years. Primary secondary outcome measures 10-year CVD was determined Framingham Risk Score HCV-positive...
Pediatric hepatic cancer is a rare malignancy, comprising only approximately 2% of all cancers diagnosed in children aged <15 years. The authors sought to describe trends pediatric incidence and survival Ontario, Canada; the United States; Australia.Children years who were with from 1985 through 2013 ascertained population-based registries followed time diagnosis until December 31, 2015. Age-standardized 5-year relative calculated for each jurisdiction. Multivariable flexible parametric...
Childhood cancer survivors face education and employment challenges due to physical, cognitive, psychosocial effects of the disease treatments, with few established programs assist them. The objectives this study were describe implementation Goal Attainment Scaling (GAS) evaluate an educational vocational counseling program for childhood cancer, analyze patterns engagement client outcomes, stratified by demographic diagnostic characteristics.A population-based retrospective cohort who...
Background Medical imaging is an integral part of healthcare. Globalization has resulted in increased mobilization migrants to new host nations. The association between migration status and utilization medical unknown. Methods findings A retrospective population-based matched cohort study was conducted Ontario, Canada from April 1, 1995 December 31, 2016. total 1,848,222 were 1:1 nonmigrants the year on age, sex, geography. Utilization computed tomography (CT), magnetic resonance (MRI),...
Differentiated thyroid carcinoma (DTC) in children, adolescents, and young adults is associated with excellent prognosis. However, little known about the long-term utilization of healthcare resources among survivors. The objective this study was to compare DTC survivors general population, a focus on pulmonary-related resource utilization. Population-based linked data were used retrospectively ascertain patients from Ontario Cancer Registry, age <30 years at diagnosis between 1992 2011....