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Miguel Á. Sanz

ORCID: 0000-0003-1489-1177
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A5017341923
Research Areas
  • Acute Myeloid Leukemia Research
  • Retinoids in leukemia and cellular processes
  • Acute Lymphoblastic Leukemia research
  • Hematopoietic Stem Cell Transplantation
  • Chronic Myeloid Leukemia Treatments
  • Multiple Myeloma Research and Treatments
  • Neutropenia and Cancer Infections
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Chronic Lymphocytic Leukemia Research
  • Blood groups and transfusion
  • Polyomavirus and related diseases
  • Platelet Disorders and Treatments
  • Hematological disorders and diagnostics
  • Antifungal resistance and susceptibility
  • Lymphoma Diagnosis and Treatment
  • Fungal Infections and Studies
  • Histone Deacetylase Inhibitors Research
  • Protein Degradation and Inhibitors
  • Antioxidant Activity and Oxidative Stress
  • Blood disorders and treatments
  • Bone and Joint Diseases
  • Cancer Treatment and Pharmacology
  • Drug-Induced Ocular Toxicity
  • Cancer Genomics and Diagnostics
  • Hemoglobinopathies and Related Disorders

Universitat de València
 2016-2025

Instituto de Investigación Sanitaria La Fe
 2005-2025

Hospital Universitari i Politècnic La Fe
 2015-2024

Centro de Investigación Biomédica en Red de Cáncer
 2017-2024

Vall d'Hebron Hospital Universitari
 1990-2024

Hospital San Pedro de Alcántara
 2010-2024

Instituto Politécnico Nacional
 2014-2024

Weatherford College
 2024

Aurora Medical Center
 2024

Centre Hospitalier Universitaire de Toulouse
 2012-2024

 International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes
OPENALEX - Publications 
Peter L. Greenberg Christopher Cox Michelle M. LeBeau Pierre Fenaux Pierre Morel and 10 more Guillermo Sanz Miguel Á. Sanz Teresa Vallespı́ Terry J. Hamblin David Oscier Kazuma Ohyashiki Keisuke Toyama Carlo Aul Ghulam Mufti John M. Bennett

10.1182/blood.v89.6.2079 article EN Blood 1997-03-15
 Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group
OPENALEX - Publications 
Francesco Rodeghiero Roberto Stasi Terry Gernsheimer Marc Michel Drew Provan and 15 more Donald M. Arnold James B. Bussel Douglas B. Cines Beng H. Chong Nichola Cooper Bertrand Godeau Klaus Lechner Maria Gabriella Mazzucconi Robert McMillan Miguel Á. Sanz Paul Imbach Victor S. Blanchette Thomas Kühne Marco Ruggeri James N. George

10.1182/blood-2008-07-162503 article EN Blood 2008-11-13
 Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with aFLT3Mutation
OPENALEX - Publications 
Richard M. Stone Sumithra J. Mandrekar Ben L. Sanford Kristina Laumann Susan M. Geyer and 24 more Clara D. Bloomfield Christian Thiede Thomas W. Prior Konstanze Döhner Guido Marcucci Francesco Lo‐Coco Rebecca B. Klisovic Andrew H. Wei Jorge Sierra Miguel Á. Sanz Joseph Brandwein Théo de Witte Dietger Niederwieser Frederick R. Appelbaum Bruno C. Medeiros Martin S. Tallman Jürgen Krauter Richard F. Schlenk Arnold Ganser Hubert Serve Gerhard Ehninger Sergio Amadori Richard A. Larson Hartmut Döhner

Patients with acute myeloid leukemia (AML) and a FLT3 mutation have poor outcomes. We conducted phase 3 trial to determine whether the addition of midostaurin - an oral multitargeted kinase inhibitor that is active in patients standard chemotherapy would prolong overall survival this population.We screened 3277 patients, 18 59 years age, who had newly diagnosed AML for mutations. were randomly assigned receive (induction therapy daunorubicin cytarabine consolidation high-dose cytarabine)...

10.1056/nejmoa1614359 article EN New England Journal of Medicine 2017-06-23
 Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
OPENALEX - Publications 
Hagop Kantarjian Anthony S. Stein Nicola Gökbuget Adele K. Fielding Andre C. Schuh and 21 more Josep‐María Ribera Andrew H. Wei Hervé Dombret Robin Foà Renato Bassan Önder Arslan Miguel Á. Sanz Julie Bergeron Fatih Demırkan Ewa Lech‐Marańda Alessandro Rambaldi Xavier Thomas Heinz-August Horst Monika Brüggemann Wolfram Klapper Brent L. Wood A. Fleishman Dirk Nagorsen Christopher P. Holland Zachary Zimmerman Max S. Topp

Blinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B-cell precursor ALL on the basis of single-group trials showed efficacy manageable toxic effects.In this multi-institutional phase 3 trial, we randomly assigned adults heavily pretreated ALL, 2:1 ratio, receive either blinatumomab standard-of-care...

10.1056/nejmoa1609783 article EN New England Journal of Medicine 2017-03-01
 Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
OPENALEX - Publications 
David J. Kuter James B. Bussel Roger M. Lyons Vinod Pullarkat Terry Gernsheimer and 27 more Francis M. Senecal Louis M. Aledort James N. George Craig M. Kessler Miguel Á. Sanz Howard A. Liebman Frank T. Slovick J. Th. M. de Wolf Emmanuelle Bourgeois Troy H. Guthrie Adrian C. Newland Jeffrey S. Wasser Solomon I. Hamburg Carlos Grande François Lefrère Alan Lichtin Michael D. Tarantino Howard R. Terebelo Jean‐François Viallard Francis J. Cuevas Ronald S. Go David H. Henry Robert L. Redner Lawrence Rice Martin R. Schipperus Ding‐Ding Guo Janet L. Nichol

10.1016/s0140-6736(08)60203-2 article EN The Lancet 2008-02-01
 A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia
OPENALEX - Publications 
Pierre Fenaux Claude Chastang Sylvie Chevret Miguel Á. Sanz Hervé Dombret and 20 more E Archimbaud Martin F. Fey Consuelo Rayón Françoise Huguet Jean‐Jacques Sotto Claude Gardin Pascale Cony Makhoul Philippe Travade Éric Solary Nathalie Fegueux Dominique Bordessoule Jesús F. San Miguel H. Link B Desablens Aspasia Stamatoullas Éric Deconinck Frédéric Maloisel Sylvie Castaigné Claude Preudhomme Laurent Degos

10.1182/blood.v94.4.1192 article EN Blood 1999-08-15
 Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups.
OPENALEX - Publications 
Miguel Á. Sanz Francesco Lo‐Coco Guillermo Martı́n Giuseppe Avvisati Consuelo Rayón and 15 more Tiziano Barbui Joaquín Diaz‐Mediavilla Giuseppe Fioritoni José D. González Vincenzo Liso Jordi Esteve Felicetto Ferrara Pascual Bolufer Carlo Bernasconi Marcos González Francesco Rodeghiero Dolors Colomer Maria Concetta Petti Josep‐María Ribera Franco Mandelli

10.1182/blood.v96.4.1247 article EN Blood 2000-08-15
 Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group
OPENALEX - Publications 
Miguel Á. Sanz Guillermo Martı́n Marcos González Ángel León Chelo Rayón and 14 more Concha Rivas Dolors Colomer Elena Amutio Francisco Capote Giuseppe Milone Javier de la Serna Javier Gómez‐Román Eva Barragán Juan Bergua Lourdes Escoda Ricardo Parody Silvia Negri Marı́a José Calasanz Pascual Bolufer

10.1182/blood-2003-07-2462 article EN Blood 2003-10-23
 A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RARalpha-positive acute promyelocytic leukemia. PETHEMA group.
OPENALEX - Publications 
Miguel Á. Sanz Guillermo Martı́n Consuelo Rayón Jordi Esteve Marcos González and 17 more Joaquín Diaz‐Mediavilla Pascual Bolufer Eva Barragán María José Terol José D. González Dolors Colomer Carmen Chillón Concha Rivas Teresa Gómez Josep‐María Ribera Rafael Bornstein Javier Gómez‐Román Marı́a José Calasanz Jesús Arias Carmen Alvarez-Domı́nguez Fernando Ramos Guillermo Debén

10.1182/blood.v94.9.3015 article EN Blood 1999-11-01
 Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients
OPENALEX - Publications 
Guillermo Sanz Miguel Á. Sanz Teresa Vallespı́ MC Cañizo Marta Torrabadella and 3 more Sonia García-Merino D. Irriguible Jesús F. San Miguel

10.1182/blood.v74.1.395.395 article EN Blood 1989-07-01
 Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
OPENALEX - Publications 
Mark J. Levis Farhad Ravandi Eunice S. Wang Maria R. Baer Alexander E. Perl and 27 more Steven Coutré Harry P. Erba Robert K. Stuart Michele Baccarani Larry D. Cripe Martin S. Tallman Giovanna Meloni Lucy A. Godley Amelia Langston Sergio Amadori Ian D. Lewis Arnon Nagler Richard M. Stone Karen Yee Anjali S. Advani Dan Douer W Wiktor-Jędrzejczak Gunnar Juliusson Mark R. Litzow Stephen H. Petersdorf Miguel Á. Sanz Hagop M. Kantarjian Takashi Sato Lothar Tremmel Debra M. Bensen-Kennedy Donald Small B. Douglas Smith

10.1182/blood-2010-08-301796 article EN Blood 2011-01-27
 Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors
OPENALEX - Publications 
Pau Montesinos Juan Bergua Edo Vellenga Chelo Rayón Ricardo Parody and 15 more Javier de la Serna Ángel León Jordi Esteve Giuseppe Milone Guillermo Debén Concha Rivas Marcos González Mar Tormo Joaquín Diaz‐Mediavilla José D. González Silvia Negri Elena Amutio Salut Brunet Bob Löwenberg Miguel Á. Sanz

10.1182/blood-2008-07-168617 article EN Blood 2008-10-23
 Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin
OPENALEX - Publications 
Javier de la Serna Pau Montesinos Edo Vellenga Chelo Rayón Ricardo Parody and 15 more Ángel León Jordi Esteve Juan Bergua Giuseppe Milone Guillermo Debén Concha Rivas Marcos González Mar Tormo Joaquín Diaz‐Mediavilla José D. González Silvia Negri Elena Amutio Salut Brunet Bob Löwenberg Miguel Á. Sanz

10.1182/blood-2007-07-100669 article EN Blood 2008-01-15
 Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome
OPENALEX - Publications 
Miguel Á. Sanz Pau Montesinos Chelo Rayón Alexandra Holowiecka Javier de la Serna and 15 more Giuseppe Milone Elena de Lisa Salut Brunet Vicente Rubio Josep‐María Ribera Concha Rivas Isabel Krsnik Juan Bergua José González Joaquín Diaz‐Mediavilla Rafael Rojas F. Manso Gert J. Ossenkoppele José D. González Bob Löwenberg

10.1182/blood-2010-01-266007 article EN Blood 2010-04-15
 Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia
OPENALEX - Publications 
Konstanze Döhner Christian Thiede Nikolaus Jahn Ekaterina Panina Agnes Gambietz and 32 more Richard A. Larson Thomas W. Prior Guido Marcucci Dan Jones Jürgen Krauter Michael Heuser Maria Teresa Voso Tiziana Ottone Josep Nomdedéu Sumithra J. Mandrekar Rebecca B. Klisovic Andrew H. Wei Jorge Sierra Miguel Á. Sanz Joseph Brandwein Théo de Witte Joop H. Jansen Dietger Niederwieser Frederick R. Appelbaum Bruno C. Medeiros Martin S. Tallman Richard F. Schlenk Arnold Ganser Hubert Serve Gerhard Ehninger Sergio Amadori Insa Gathmann Axel Benner Céline Pallaud Richard M. Stone Hartmut Döhner Clara D. Bloomfield

10.1182/blood.2019002697 article EN Blood 2019-12-11
 A Randomized, Double-Blind, Placebo-Controlled, Phase III Study of Filgrastim in Remission Induction and Consolidation Therapy for Adults With De Novo Acute Myeloid Leukemia
OPENALEX - Publications 
Gerhard Heil Dieter Hoelzer Miguel Á. Sanz Klaus Lechner John A. Liu Yin and 7 more Giuseppe Francesco Sferrazza Papa L. Noens Jeff Szer Arnold Ganser Caroline O’Brien James Matcham Alan Barge

10.1182/blood.v90.12.4710 article EN Blood 1997-12-15
 Incidence, Clinical Features, and Outcome of AllTrans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia
OPENALEX - Publications 
Stéphane de Botton Hervé Dombret Miguel Á. Sanz Jesús F. San Miguel Denis Caillot and 16 more R Zittoun Martine Gardembas A. Stamatoulas E Conde A. Guerci Claude Gardin Katherine M. Geiser D. Cony Makhoul Oumédaly Reman Javier de la Serna F. Lefrere Christine Chomienne Claude Chastang L Degos Pierre Fenaux the European APL Group

10.1182/blood.v92.8.2712 article EN Blood 1998-10-15
 Primary Plasma Cell Leukemia: Clinical, Immunophenotypic, DNA Ploidy, and Cytogenetic Characteristics
OPENALEX - Publications 
Ramón García‐Sánz Alberto Órfão Marcos González María Dolores Tabernero Joan Bladé and 6 more Marı́a Jesús Moro Javier Fernández‐Calvo Miguel Á. Sanz José Antonio Pérez‐Simón Ana Rasillo Jesús F. San Miguel

10.1182/blood.v93.3.1032 article EN Blood 1999-02-01
 Comparison of the Results of the Treatment of Adolescents and Young Adults With Standard-Risk Acute Lymphoblastic Leukemia With the Programa Español de Tratamiento en Hematología Pediatric-Based Protocol ALL-96
OPENALEX - Publications 
Josep‐María Ribera Albert Oriol Miguel Á. Sanz Mar Tormo Pascual Fernández and 10 more Eloy del Potro Eugenia Abellá Javier Bueno Ricardo Parody Pilar Bastida Carlos Grande Inmaculada Heras Concepción Bethencourt Evarist Feliú Juan-José Ortega

Retrospective studies have shown that adolescents and young adults with acute lymphoblastic leukemia (ALL) treated pediatric protocols better outcomes than similarly aged patients adult protocols, but prospective comparing using schedules are scarce. The ALL-96 protocol was addressed to compare the toxicity results of a pediatric-based in (age 15-18 years) 19-30 standard-risk (SR) ALL.Adolescents (n = 35) 46) received standard five-drug/5-week induction course followed by two cycles early...

10.1200/jco.2007.13.7265 article EN Journal of Clinical Oncology 2008-04-08
 Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies
OPENALEX - Publications 
Guillermo Sanz Silvana Saavedra Dolores Planelles Leonor Senent José Cervera and 19 more Eva Barragán Carmen Jiménez Luís Larrea Guillermo Martı́n Jesús Martı́nez Isidro Jarque Federico Moscardó Gemma Plumé Rafael Andreu A. Regadera Inmaculada Garcı́a Susana Mollá Pilar Solves Javier de la Rubia Pascual Bolufer Luis Benlloch María Angeles Soler Marı́a L. Marty Miguel Á. Sanz

10.1182/blood.v98.8.2332 article EN Blood 2001-10-15
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