A5008564951- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Bone and Joint Diseases
- Eosinophilic Disorders and Syndromes
- Erythrocyte Function and Pathophysiology
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- CNS Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Hemoglobinopathies and Related Disorders
- HIV/AIDS drug development and treatment
- Blood properties and coagulation
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
Institut Català d'Oncologia
2010-2021
Universitat Autònoma de Barcelona
2012-2021
Josep Carreras Leukaemia Research Institute
2011-2020
Fundación Josep Carreras Contra la Leucemia
2011-2019
Hospital General Universitario de Alicante Doctor Balmis
2005-2019
Hospital Universitari Germans Trias i Pujol
2005-2017
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2017
Hospital Clínica Benidorm
2012-2014
Hospital de Sant Pau
2014
University of Birmingham
2014
Background About one half of adults with acute lymphoblastic leukemia are not cured the disease and ultimately die. The objective this study was to explore factors influencing outcome adult patients relapsed leukemia.Design Methods We analyzed characteristics, prognostic for survival after first relapse in a series 263 (excluding those mature B-cell leukemia) prospectively enrolled four consecutive risk-adapted PETHEMA trials.Results median overall 4.5 months (95% CI, 4–5 months) 5-year 10%...
Minimal residual disease (MRD) is an important prognostic factor in adults with acute lymphoblastic leukemia (ALL) and may be used for treatment decisions. The Programa Español de Tratamientos en Hematología (PETHEMA) ALL-AR-03 trial (Treatment of High Risk Adult Acute Lymphoblastic Leukemia [LAL-AR/2003]) assigned adolescent adult patients (age 15 to 60 years) high-risk ALL (HR-ALL) without the Philadelphia (Ph) chromosome chemotherapy or allogeneic hematopoietic stem-cell transplantation...
This study determines, within the frame of current therapeutic possibilities, impact chronic nonleukemic myeloproliferative disorders on expected survival. The survival data for 1067 patients (454 with polycythemia vera, 247 essential thrombocythemia, and 366 idiopathic myelofibrosis) were collected from 38 Spanish institutions. actuarial probability each group was compared that age-matched sex-matched control population. vera thrombocythemia did not differ population (P = 0.92 and, 0.22,...
Retrospective studies have shown that adolescents and young adults with acute lymphoblastic leukemia (ALL) treated pediatric protocols better outcomes than similarly aged patients adult protocols, but prospective comparing using schedules are scarce. The ALL-96 protocol was addressed to compare the toxicity results of a pediatric-based in (age 15-18 years) 19-30 standard-risk (SR) ALL.Adolescents (n = 35) 46) received standard five-drug/5-week induction course followed by two cycles early...
The clinical history and biochemical hematologic variables for 44 consecutive patients diagnosed with anorexia nervosa were recorded. Bone marrow aspirates biopsy specimens analyzed by standard morphologic procedures, bone adipocytes studied morphometrically. of the was classified as normal (5 cases [11%]), hypoplastic or aplastic (17 [39%]), partial focal gelatinous degeneration (13 [30%]), complete (GDBM; 9 [20%]). These patterns correlated amount weight loss (P = .005) but not other...
Combined highly active anti‐retroviral therapy (HAART) with protease and reverse transcriptase inhibitors has modified the natural history of opportunistic infections neoplasms in human immunodeficiency virus (HIV)‐infected patients. We analysed influence HAART on response to treatment survival a series 58 patients acquired immune deficiency syndrome (AIDS)‐related non‐Hodgkin's lymphoma (NHL) treated CHOP (cyclophosphamide, hydroxydoxorubicin, vincristine prednisone). Two groups were...
Abstract. Polymorphonuclear leucocyte function was investigated in twenty patients with alcoholic cirrhosis and three cryptogenic cirrhosis. Bacterial ingestion, oxygen‐dependent bactericidal capacity, chemotactic response were measured. Serum dependent abnormalities common; they included deficiencies of ingestion all subsequent metabolic events (three patients), (one patient), cytochrome c reduction iodination (six isolated deficiency (ten (fourteen out eighteen patients). Serum‐independent...
Some copy number alterations (CNAs) have independent prognostic significance for adults with acute lymphoblastic leukemia (ALL).This study analyzed via multiplex ligation-dependent probe amplification the frequency and impact of CNAs 12 genetic regions in 142 adolescents de novo precursor B-cell ALL.The cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) deletion (59 or 42%) was most frequent CNA, it followed by Ikaros family zinc finger 1 (IKZF1) losses (49 35%). IKZF1 deletions were more...
Hepatosplenic γ δ T-cell lymphoma (HS TCL) is an uncommon type of peripheral lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case HS TCL leukaemic course patient Crohn's disease who had received azathioprine during the previous 55 years. Sinusoidal infiltration by atypical lymphocytes was observed liver, spleen and bone marrow typical cytogenetic abnormalities (isochromosome 7 trisomy 8) were found. The did not...
Summary We have analysed the immunological characteristics of blasts from 89 acute lymphoblastic leukaemia (ALL) cases (62 adults and 27 children), by using a panel antilymphoid myeloid associated monoclonal antibodies (McAb) APAAP method, which detects membrane cytoplasmic expression antigens. The McAb CD19 was marker most consistently expressed in B lineage ALL, being positive 100% cases, compared to CD24 CD22 82% 79%, respectively. Similarly, for T lymphoid lineage, CD3 reliable specific...
Only 20-30% of elderly patients with acute lymphoblastic leukemia (ALL) are enrolled in clinical trials because co-morbid disorders or poor performance status. We present the results treatment Philadelphia chromosome-negative (Ph-) ALL over 55 yr treated PETHEMA ALL-96 trial.From 1996 to 2006, 33 > = Ph- were included. Induction therapy was vincristine, daunorubicin, prednisone, asparaginase, and cyclophosphamide 5 weeks. Central nervous system (CNS) prophylaxis involved triple intrathecal...
Abstract Recurrence of acute lymphoblastic leukemia (ALL) in the central nervous system (CNS) confers a poor prognosis, although to authors' knowledge, only few studies have analyzed this issue adults. For current study, authors frequency, predictive factors, and prognosis CNS involvement recurrence adult patients with ALL who did not receive cranial irradiation for prophylaxis. Four hundred sixty‐seven (age ≥15 years) were treated on 4 protocols: ALL‐89 (standard‐risk high‐risk ALL; n = 108...
Journal Article Specific cutaneous manifestations of Waldenström's macroglobulinaemia. A report two cases Get access J.M. MASCARO, MASCARO Department Dermatology and Hospital Clinico y Provinciai, Barcelona, Spain J.M.Mascaro, Dermatology, Provincial, Casanova 143, Barcelona‐36, Spain. Search for other works by this author on: Oxford Academic Google Scholar E. MONTSERRAT, MONTSERRAT Postgraduate School Haematology 'Farreras Valenti', University Barcelona T. ESTRACH, ESTRACH FELIU, FELIU J....
Abstract Background and aim: Flow cytometry (FCM) analysis of cerebrospinal fluid (CSF) is more sensitive than conventional cytology (CC) for diagnosis lymphomatous meningeosis, but the clinical significance occult central nervous system (CNS) disease (positive FCM with negative CC) remains unknown. Patients methods: CSF samples from 105 patients newly diagnosed aggressive lymphomas at high risk CNS involvement were prospectively studied by both CC FCM, results correlated cumulative...
Since the introduction of combination antiretroviral therapy (cART) patients with HIV-related diffuse large B-cell lymphoma (DLBCL) show better control immunosuppression, which may have an impact on characteristics and prognosis disease. We aimed to compare clinical presentation HIV-unrelated DLBCL treated rituximab, cyclophosphamide, adriamycin, vincristine, prednisone (R-CHOP) in cART era.Eighty-one HIV-infected included a Spanish multicentre trial were compared 84 HIV-uninfected diagnosed...