Neus Villamor
A5024516606- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Glycosylation and Glycoproteins Research
- Calcium signaling and nucleotide metabolism
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- T-cell and Retrovirus Studies
- Ubiquitin and proteasome pathways
- CNS Lymphoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Protein Degradation and Inhibitors
- Genetic factors in colorectal cancer
- Platelet Disorders and Treatments
- Cell death mechanisms and regulation
Hospital Clínic de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2024
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2023-2024
Centro de Investigación Biomédica en Red de Cáncer
2017-2024
Fundació Clínic per a la Recerca Biomèdica
2023
Instituto de Salud Carlos III
2017-2022
Universitat de Barcelona
2010-2021
Hudson Institute
2019
John Wiley & Sons (United States)
2019
Massachusetts General Hospital
2019
Chronic lymphocytic leukaemia (CLL), the most frequent in adults Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, characterized respectively by high or low number of somatic hypermutations region immunoglobulin genes. The changes leading to pathogenesis are still poorly understood. Here we performed whole-genome sequencing four cases CLL identified 46 mutations that potentially affect gene...
The mutational status of immunoglobulin heavy-chain variable-region (IgVH ) genes in the leukemic cells chronic lymphocytic leukemia (CLL) is an important prognostic factor disease. We investigated whether expression ZAP-70 by CLL correlated with IgVH status, disease progression, and survival.
Significance This is a comprehensive whole-genome/whole-exome analysis of mantle cell lymphoma (MCL). We sequenced 29 MCL cases and validated the findings by target sequencing 172 additional tumors. identified recurrent mutations in genes regulating chromatin modification such as NOTCH2 that have major impact on clinical outcome. Additionally, we demonstrated subclonal heterogeneity tumors already at diagnosis modulation mutational architecture progression disease. The identification new...
Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate treatment at diagnosis. To define molecular criteria permit recognition of such cases, we compared the clinicopathologic features, gene expression, and genomic profile patients who had or conventional (iMCL cMCL). Patients iMCL displayed nonnodal leukemic predominantly hypermutated IGVH noncomplex karyotypes. cMCL shared common...
Tumor microenvironment influences the behavior of follicular lymphoma (FL), although specific cell subsets involved are not well known. The aim this study was to determine impact programmed death 1 (PD-1) -positive inhibitory immunoregulatory lymphoid cells in clinicobiologic features and outcome patients with FL.We examined samples from 100 (53 men 47 women; median age, 54 years) at diagnosis, as 32 first relapse, a recently generated monoclonal antibody against PD-1. were quantified using...
In chronic lymphocytic leukemia (CLL) the level of minimal residual disease (MRD) after therapy is an independent predictor outcome. Given increasing number new agents being explored for CLL therapy, using MRD as a surrogate could greatly reduce time necessary to assess their efficacy. this European Research Initiative on (ERIC) project we have identified and validated flow-cytometric approach reliably quantitate cells 0.0010% (10−5). The assay comprises core panel six markers (i.e. CD19,...
Abstract Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into very aggressive large B cell lymphoma conferring dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome, epigenome and transcriptome, combined with single-cell DNA/RNA-sequencing analyses functional experiments, 19 cases CLL developing RT. Studying 54 longitudinal samples covering up to years disease course, we uncovered minute subclones...
Purpose To study the main clinicobiologic features, response, and outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to primary site, lymph node, or different extranodal organs disease. Patients Methods We included 382 consecutively diagnosed DLBCL in a single institution during 13-year period. Morphology, immunophenotyping, proliferation index, differentiation profile, bcl-2/JH rearrangement, clinical characteristics were analyzed site lymphoma. Results Sites disease...
Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome -exome sequencing contributed to the characterization of mutational spectrum disease, but underlying transcriptional profile is still poorly understood. We have performed deep RNA in different subpopulations normal B-lymphocytes CLL cells from a cohort 98 patients, characterized landscape with unprecedented resolution. detected thousands elements differentially expressed between B cells,...
Summary. We evaluated the efficacy and toxicity of fludarabine combined with cyclophosphamide mitoxantrone (FCM) in patients relapsed or resistant chronic lymphocytic leukaemia (CLL). In total, 37 recurrent CLL received FCM: 25 mg/m 2 intravenously (IV), d 1–3; 200 IV, 6 1, at 4‐week intervals for up to six courses. Moreover, 23 FCM 600 i.v. 8 on 1. addition clinical methods, response was assessed using cytofluorometric molecular techniques. ‘ vitro ’ sensitivity regimen also analysed 20...