Beatriz García-Torre
A5041450588- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Protein Degradation and Inhibitors
- 14-3-3 protein interactions
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Glycosylation and Glycoproteins Research
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020-2024
Abstract Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into very aggressive large B cell lymphoma conferring dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome, epigenome and transcriptome, combined with single-cell DNA/RNA-sequencing analyses functional experiments, 19 cases CLL developing RT. Studying 54 longitudinal samples covering up to years disease course, we uncovered minute subclones...
Multiple myeloma (MM) is a plasma cell neoplasm associated with broad variety of genetic lesions. In spite this heterogeneity, MMs share characteristic malignant phenotype whose underlying molecular basis remains poorly characterized. the present study, we examined cells from MM using multi-epigenomics approach and demonstrated that, when compared to normal B cells, showed an extensive activation regulatory elements, in part affecting coregulated adjacent genes. Among target genes...
Abstract Sterile alpha motif and histidine-aspartate (HD) domain–containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with ara-CTPase activity that confers cytarabine (ara-C) resistance in several hematological malignancies. Targeting SAMHD1’s has recently been demonstrated to enhance ara-C efficacy acute myeloid leukemia. Here, we identify the transcription factor SRY-related HMG-box containing 11 (SOX11) as novel direct binding partner first known endogenous...
The sterile alpha motif and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with ara-CTPase activity that confers cytarabine (ara-C) resistance in several haematological malignancies. Targeting SAMHD1's has recently been demonstrated to enhance ara-C efficacy acute myeloid leukemia. Here, we identify the transcription factor SRY-related HMG-box 11 (SOX11) as novel direct binding partner first known endogenous inhibitor of...
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Abstract Introduction: Clonal evolution drives cancer development due to the emergence and/or selection of proliferatively advantageous subclones. Its understanding may facilitate design anticipation-based management strategies. Richter transformation (RT) is a paradigmatic tumor in which chronic lymphocytic leukemia (CLL), an indolent neoplasia mature B-cells, transforms into high-grade lymphoma, usually diffuse large B-cell lymphoma (DLBCL), conferring dismal prognosis. The evolutionary...