A5059112519- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Mycobacterium research and diagnosis
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
Centro de Investigación Biomédica en Red de Cáncer
2018-2024
Navarre Institute of Health Research
2023-2024
Clinica Universidad de Navarra
2024
Centre for Biomedical Network Research on Rare Diseases
2023
Universidad de Navarra
2018-2023
Multiple myeloma (MM) is an incurable disease, whose clinical heterogeneity makes its management challenging, highlighting the need for biological features to guide improved therapies. Deregulation of specific long non-coding RNAs (lncRNAs) has been shown in MM, nevertheless, complete lncRNA transcriptome not yet elucidated. In this work, we identified 40,511 novel lncRNAs MM samples. accounted 82% and were more heterogeneously expressed than coding genes. A total 10,351 overexpressed 9,535...
// Andoni Garitano-Trojaola 1 , Edurne San José-Enériz Teresa Ezponda Juan Pablo Unfried 2 Arantxa Carrasco-León Nerea Razquin Marina Barriocanal Amaia Vilas-Zornoza Bruno Sangro 3 Victor Segura 4 Felipe Prósper 1, 5, * Puri Fortes 2, and Xabier Agirre Laboratory of Myeloproliferative Syndromes, Oncology Area, Foundation for Applied Medical Research, IDISNA, CIBERONC, University Navarra, Pamplona, Spain Department Gene Therapy Hepatology, Liver Unit, CIBEREHD,...
Multiple myeloma (MM) is a plasma cell neoplasm associated with broad variety of genetic lesions. In spite this heterogeneity, MMs share characteristic malignant phenotype whose underlying molecular basis remains poorly characterized. the present study, we examined cells from MM using multi-epigenomics approach and demonstrated that, when compared to normal B cells, showed an extensive activation regulatory elements, in part affecting coregulated adjacent genes. Among target genes...
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Background: Deregulation of long non‐coding RNAs (lncRNAs) is emerging as a common hallmark different human tumors and their investigation may uncover novel biomarkers oncogenic mechanisms. In multiple myeloma (MM), the alteration some lncRNAs has been detected, suggesting that they can play an important role, but complete transcriptome in this disease not yet known. Aims: present work, our objective was to characterize MM, determine functional involvement myelomagenesis clinical outcome...