A5036313621- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Blood groups and transfusion
- Digital Imaging for Blood Diseases
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Artificial Intelligence in Healthcare
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Multiple and Secondary Primary Cancers
- Eosinophilic Disorders and Syndromes
- Cell death mechanisms and regulation
- Parvovirus B19 Infection Studies
- Infections and bacterial resistance
- Helminth infection and control
- Antifungal resistance and susceptibility
National Center for Cancer Care and Research
2013-2024
Hamad Medical Corporation
2013-2024
Qatar University
2023
Hôpital Farhat Hached
1994-2011
University of Sousse
2006
Sub population of cancer cells, referred to as Cancer stem cells (CSCs) or tumor initiating have enhanced metastatic potential that drives progression.CSCs been found hold intrinsic resistance present chemotherapeutic strategies.This is attributed DNA reparability, slower cell cycle and high levels detoxifying enzymes.Hence, CSCs pose an obstacle against chemotherapy.The increasing prevalence drug resistant cancers necessitates further research treatment development.The current review...
Objectives While delays in leukemia detection remain an ongoing challenge hematologic cancer care, little is known about the factors associated with these delays. This article focuses on identifying barriers hindering timely diagnosis of through a cohort analysis (2016-2021) 220 Acute Myeloid Leukemia (AML), 161 Chronic (CML), 90 Lymphocytic (ALL), and 121 (CLL) patients Qatar. Methods Of 592 used for study, subsets were identified analyzed delay (423), risk stratification (437), stage...
Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and vitro studies. However, SNG potential yet to be established multiple myeloma (MM), largely incurable malignancy of plasma cells. In this study, we aimed investigate the anti-proliferative pro-apoptotic activities panel MM cell lines (U266, IM9, MM1S, RPMI-8226). treatment cells resulted dose-dependent decrease viability via inducing intrinsic apoptotic pathway through...
Sanguinarine (Sang), a plant-derived compound isolated from the roots of Sanguinaria canadensis was evaluated for its potential pro-apoptotic effects in precursor B acute lymphoblastic leukemia (Pre-ALL) cell lines. Treatment 697, REH, RS4;11, and SupB15 lines with Sang exhibited significant inhibition viability via induction apoptotic death. Sang-mediated apoptosis found to be associated increased expression proapoptotic bax concomitant decrease Bcl-2 leading depolarization mitochondria...
The use of ill-suited antibiotics is a significant risk factor behind the increase in mortality, morbidity, and economic burden for patients who are under treatment hematological malignancy (HM) bloodstream infections (BSI). Such unfitting choices intensify evolution resistant variants which public health concern due to possible healthcare-associated infection spread general population. Hence, this study aims evaluate antibiograms with BSI factors associated septicemia. A total 1166 febrile...
Background Multiple myeloma (MM) is one of the most common hematological malignancies globally, and it projected to increase in coming years. It occurs more frequently males affects older individuals. Presenting symptoms can range from being asymptomatic severely debilitating. The objective this study was determine epidemiology, clinical features, prognostic outcomes patients with MM only tertiary cancer hospital Qatar. Methods Patients symptomatic diagnosed at National Center for Cancer...
Therapeutic agents used in the treatment of cancer are known to develop resistance against cells. Hence, there is a continuing need investigate novel for and management cancer. Antitumor activity greensporone C (GC), new resorcylic acid lactone isolated from an organic extract culture Halenospora sp. freshwater fungus, was subjected screening panel leukemic cell lines (K562, U937, AR320). In all three lines, proliferation inhibited dose-dependent fashion. GC further arrested cells SubG0...
Strongyloides stercoralis (S.S.) is a human intestinal parasite, which may lead to complicated strongyloidiasis. We report case of disseminated strongyloidiasis following the treatment myeloma. The patient developed skin lesions, respiratory distress, aseptic meningitis and bacterial fungal sepsis. diagnosis was established through endotracheal tube secretions. Despite with Ivermectin Albendazole, outcome fatal. value screening for unclear but be benefit in patients hematological...
Venetoclax is a BCL-2 inhibitor with proven efficacy in patients multiple myeloma (MM) and translocation t(11;14). However, its role plasma cell leukemia (PCL) remains unclear. Herein, we aimed to report case of relapsed MM secondary PCL t(11;14) achieving complete (CR) durable remission venetoclax therapy.
Perforin gene (PRF1) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH) and lymphoma. The aim present study was to determine whether a aggregation hematological malignancies harbor germline perforin mutations. For this purpose, 81 unrelated families from Tunisia France aggregated were investigated. variants detected PRF1 coding region amounted 3.7% (3/81). Two three previously described: p.Ala91Val pathogenic mutation...
Tuberculosis (TB) can present with various forms and occasionally be mistaken for malignancy. Hereby, we report a 53-year-old man diagnosed treated Burkitt's lymphoma in 2009 who achieved complete remission confirmed by computed tomography (CT) scan. During the follow-up 2 years later, he complained of left hip pain that warranted investigation magnetic resonance imaging whole-body <sup>18</sup>F-fludeoxyglucose-positron emission (FDG-PET)/CT which showed benign lesion associated...
Idiopathic thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder mediated by autoantibodies directed against ADAMTS13. This provides rationale for the use of rituximab in this disorder. We report our experience and outcome 10 cases TTP (9 refractory 1 relapsing) successfully treated with combination plasma exchange (PE) other immunosuppressive treatments.The diagnosis was based on clinical criteria supported severe deficiency ADAMTS13 activity presence inhibitors seven...
Mixed phenotype acute leukemia (MPAL) is considered as a rare type of with an incidence less than 4% all based on the most recent 2008 WHO classification. Common subtypes are B/myeloid and T/myeloid; B/T trilineage MPAL being extremely rare. We present case male in his 20s, whose peripheral blood smears showed 34% blast cells bone marrow 70% blasts. Immunophenotyping by multiparametric flow cytometry two populations blasts, major one B-lineage minor T-lineage. Conventional karyotyping...
Viral retinitis due to cytomegalovirus (CMV) infection is rare in patients with acute leukemia who did not receive hematopoietic stem cell transplantation. We report a case of CMV that developed 49-year-old patient lymphoblastic leukemia. The was treated salvage chemotherapy using hyper-CVAD regimen and incidence this subgroup described literature. He had very complicated course during but successfully treated, preservation visual acuity, date he complete remission. Interestingly, prior...
Production of factor VIII or IX inhibitors is a major complication limiting the efficiency substitutive therapy in haemophiliacs. Moreover, viral infections, second serious replacement therapy, may be associated to occurrence antiphospholipid antibodies which paradoxically lead thrombosis. We investigated prevalence coagulation (factor and inhibitors, antibodies) Tunisian haemophiliacs, we assessed concomitant deficiencies. Thirty-two previously treated haemophiliacs (20 A; 12 B) were...