A5026011061- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Bacterial Identification and Susceptibility Testing
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Myeloid Leukemia Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Oral Health Pathology and Treatment
- Testicular diseases and treatments
- Eosinophilic Disorders and Syndromes
- Cancer and Skin Lesions
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- COVID-19 Clinical Research Studies
- Chemotherapy-induced organ toxicity mitigation
- Pharmaceutical Practices and Patient Outcomes
National Center for Cancer Care and Research
2016-2025
Hamad Medical Corporation
2016-2024
Objectives While delays in leukemia detection remain an ongoing challenge hematologic cancer care, little is known about the factors associated with these delays. This article focuses on identifying barriers hindering timely diagnosis of through a cohort analysis (2016-2021) 220 Acute Myeloid Leukemia (AML), 161 Chronic (CML), 90 Lymphocytic (ALL), and 121 (CLL) patients Qatar. Methods Of 592 used for study, subsets were identified analyzed delay (423), risk stratification (437), stage...
Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and vitro studies. However, SNG potential yet to be established multiple myeloma (MM), largely incurable malignancy of plasma cells. In this study, we aimed investigate the anti-proliferative pro-apoptotic activities panel MM cell lines (U266, IM9, MM1S, RPMI-8226). treatment cells resulted dose-dependent decrease viability via inducing intrinsic apoptotic pathway through...
The use of ill-suited antibiotics is a significant risk factor behind the increase in mortality, morbidity, and economic burden for patients who are under treatment hematological malignancy (HM) bloodstream infections (BSI). Such unfitting choices intensify evolution resistant variants which public health concern due to possible healthcare-associated infection spread general population. Hence, this study aims evaluate antibiograms with BSI factors associated septicemia. A total 1166 febrile...
Background Multiple myeloma (MM) is one of the most common hematological malignancies globally, and it projected to increase in coming years. It occurs more frequently males affects older individuals. Presenting symptoms can range from being asymptomatic severely debilitating. The objective this study was determine epidemiology, clinical features, prognostic outcomes patients with MM only tertiary cancer hospital Qatar. Methods Patients symptomatic diagnosed at National Center for Cancer...
Coronavirus disease 2019 (COVID-19) pandemic has been a serious threat and reported with different presentations complications. Older age, along comorbidities such as diabetes, hypertension, or cardiac disease, increases the risk factors for COVID-19 severity death [N Engl J Med. 2020;382(18):1708–20 Lancet Respir 2020 05;8(5):475–81]. It is proposed that cancer patients have significantly higher incidence of severe incidents including admission to intensive care unit, necessity assisted...
<b><i>Introduction:</i></b> Multiple myeloma (MM) is a clonal neoplasm of plasma cells that may manifest as an extramedullary disease in rare cases. <b><i>Case Report:</i></b> In this case report, we present the occurrence testicular relapse 39-year-old patient with IgA MM after 3 years remission. We discuss clinical course and management unusual presentation provide comprehensive literature review involvement by MM....
Plasmacytoma of the skull base is a rare manifestation plasma cell neoplasm with only few cases documented in literature involving young adults. can be an isolated solitary lesion or secondary multiple myeloma (MM). In this study, we report clinical and radiological characteristics, management, outcomes patients under age 40 who presented plasmacytoma associated neurological manifestations. Additionally, share our experience treating case diagnosed during pregnancy, which patient exhibited...
Venetoclax is a BCL-2 inhibitor with proven efficacy in patients multiple myeloma (MM) and translocation t(11;14). However, its role plasma cell leukemia (PCL) remains unclear. Herein, we aimed to report case of relapsed MM secondary PCL t(11;14) achieving complete (CR) durable remission venetoclax therapy.
Carfilzomib is a second-generation selective proteasome inhibitor that commonly used in the treatment of relapsed or refractory multiple myeloma. associated with respiratory side effects, such as cough, dyspnea, and upper tract infection. However, severe pulmonary toxicity rare only reported few case reports.Here, we present 65-year-old male myeloma who developed life-threatening lung injury during his third cycle carfilzomib. The patient presented decreased level consciousness was found to...
The current study retrospectively evaluated cytogenetic profiles, various prognostic factors, and survival outcomes in 128 acute myeloid leukemia (AML) patients (14 ≤ age ≤70 years) admitted to the National Center for Cancer Care Research (NCCCR), Hamad Medical Corporation, Doha, Qatar, between January 2010 December 2017. median at diagnosis was 43 years, 80% were less than 60 years old; 75% of male. Cytogenetic analysis integrated into World Health Organization 2008 classification, showed...
Plasma cell neoplasms can show aberrant expression of different lineage-related antigens; however, co-expression T-cell-associated markers on malignant plasma cells is extremely rare.
Multiple Myeloma (MM) is a chronic and incurable hematologic malignancy that prevalent among the elderly. Interprofessional patient care showed superiority over physician-only in multiple settings, including MM.
In MENA region, there is a lack of evidence on Primary Myelofibrosis (PMF), leading to its underrepresentation in medical literature. This study marks the first comprehensive report PMF data Qatar, presenting findings from single-center spanning 13 years (2008-2021).
Erythema nodosum (EN) is a type of panniculitis occurring due to various conditions. It can be associated with certain malignancies or manifest as side effect drugs. This article presents unique case EN in patient chronic myeloid leukemia (CML-blast phase) following dasatinib and chemotherapy. Timely recognition appropriate management are crucial alleviate symptoms consider potential drug-induced etiology.
No abstract, as A letter to the Editor.
Reliable and rapid medical diagnosis is the cornerstone for improving survival rate quality of life cancer patients. The problem clinical decision-making pertaining to management patients with hematologic multifaceted intricate due risk therapy-induced myelosuppression, multiple infections, febrile neutropenia (FN). Myelosuppression treatment increases sepsis mortality in hematological neutropenia. A high prevalence multidrug-resistant organisms also noted such patients, which implies that...
Topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical Background: (CLL) is a monoclonal disorder characterized by progressive proliferation of dysfunctional mature lymphocytes. Its disease elderly with average age at presentation 70 years old. AYA cancer patients are defined as those patients’ ages between 15-39 according to NCCN guidelines. CLL in less than 1% the cases. However due lack enough data more knowledge experience needed Aims: To describe young adolescence...