A5079997166- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- Multiple Myeloma Research and Treatments
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Glycosylation and Glycoproteins Research
- T-cell and Retrovirus Studies
- Heat shock proteins research
- Advanced Breast Cancer Therapies
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Universitat de Barcelona
2005-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2025
Fundació Clínic per a la Recerca Biomèdica
2023-2024
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2024
National Heart Lung and Blood Institute
2009-2023
Inserm
2023
Instituto de Salud Carlos III
2018-2023
Hospital Clínic de Barcelona
2005-2015
Bentham Science Publishers (United Arab Emirates)
2013
The ubiquitin-proteasome system has recently emerged as a major target for drug development in cancer therapy. proteasome inhibitor bortezomib clinical activity multiple myeloma and mantle cell lymphoma. Here we report that Eeyarestatin I (EerI), chemical blocks endoplasmic reticulum (ER)-associated protein degradation, antitumor biologic activities similar to can synergize with bortezomib. Like bortezomib, EerI-induced cytotoxicity requires the up-regulation of Bcl-2 homology3 (BH3)-only...
Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this available our patients prompted us develop a novel CART19 based on own antibody (A3B1), followed by CD8 hinge and transmembrane region, 4-1BB- CD3z-signaling domains. We show that A3B1 CAR are highly cytotoxic specific against vitro, inducing secretion pro-inflammatory...
Effective and safe therapies are needed for the treatment of patients with giant cell arteritis (GCA). Emerging as a key cytokine in inflammation, granulocyte-macrophage colony stimulating factor (GM-CSF) may play role promoting inflammation GCA.
Mantle cell lymphoma (MCL), a rare and aggressive B-cell non-Hodgkin lymphoma, mainly develops in the lymph node (LN) creates protective immunosuppressive niche that facilitates tumor survival, proliferation chemoresistance. To capture disease heterogeneity microenvironment (TME) cues, we have developed first patient-derived MCL spheroids (MCL-PDLS) recapitulate oncogenic pathways immune multiplexed system allows easy drug screening, including immunotherapies. spheroids, integrated by B...
Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond bortezomib. We used gene expression profiling investigate the connection between proteasome inhibition, cellular response, clinical efficacy.
Abstract Purpose: Chronic lymphocytic leukemia (CLL), a malignancy of mature B cells, is incurable with chemotherapy. Signals from the microenvironment support leukemic cell survival and proliferation may confer chemotherapy resistance. ON 01910.Na (Rigosertib), multikinase phosphoinositide 3-kinase (PI3K) inhibitor, entering phase III trials for myelodysplastic syndrome. Our aim was to analyze efficacy against CLL cells in vitro investigate molecular effects this drug on tumor biology....
Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival with macrophages playing a controversial role. In the present study, using FL primary samples HK dendritic cells (FDC) mimic germinal center, together mouse models, we have analyzed three-way crosstalk of FL-FDC-macrophages derived therapeutic opportunities. Ex vivo FL-FDC co-cultures (n = 19) in co-xenografts demonstrated that favors tumor growth and, via secretion CCL2 CSF-1, promotes monocyte...
Abstract Granulysin is a cytolytic molecule released by CTL via granule-mediated exocytosis. In previous study we showed that granulysin induced apoptosis using both caspase- and ceramide-dependent -independent pathways. the present further characterize biochemical mechanism for granulysin-induced of tumor cells. Granulysin-induced death significantly inhibited Bcl-2 overexpression associated with rapid (1–5 h) loss mitochondrial membrane potential, which not mediated ceramide generation...
In an attempt to circumvent the intrinsic resistance of mantle cell lymphoma (MCL) cells apoptosis, we have analyzed their sensitivity extrinsic apoptotic signal triggered by TRAIL. We show here that TRAIL can trigger apoptosis in a majority MCL lines and primary cultures, irrespective receptor levels, Bcl-2 family members, or caspase regulator expression. was closely linked activity NF-kappaB p50 factor consequent expression cellular FLIP (c-FLIP), which accumulated into TRAIL-dependent...
Abstract Purpose: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are two incurable B-cell lymphoid neoplasms characterized by distinct clinical presentation evolution. Bendamustine hydrochloride is a multifunctional, alkylating agent with purine-like ring system that exhibits activity in multiple cancer models, including CLL MCL, but whose mechanism only partially described. Our aim was to analyze the apoptotic pathways activated bendamustine MCL together relevance of p53...
Follicular lymphoma (FL) is a common non Hodgkin's subtype in which immune escape mechanisms are implicated resistance to chemo-immunotherapy. Although molecular studies point qualitative and quantitative deregulation of checkpoints, depth cellular analysis FL lacking. Here, by functional assays silico analyses we show that subset patients displays 'high' phenotype. These cases characterized abundant infiltration PD1+ CD16+ TCRVγ9Vδ2 γδ T lymphocytes. In 3D co-culture assay (MALC), cells...
Abstract Purpose: To establish a proof-of-concept for the efficacy of anti-CD38 antibody daratumumab in poor prognosis CD38+ chronic lymphocytic leukemia (CLL) subtype. Experimental Design: The mechanism action was assessed CLL primary cells and cell lines using peripheral blood mononuclear to analyze antibody-dependent cytotoxicity (ADCC), murine human macrophages study phagocytosis (ADCP), or serum complement-dependent (CDC). effect on migration adhesion extracellular matrix characterized....