A5101450210- Cell death mechanisms and regulation
- Muscle Physiology and Disorders
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Knee injuries and reconstruction techniques
- Liver physiology and pathology
- Exercise and Physiological Responses
- Curcumin's Biomedical Applications
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Cancer Mechanisms and Therapy
- Muscle metabolism and nutrition
- Chronic Lymphocytic Leukemia Research
- Melanoma and MAPK Pathways
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Spaceflight effects on biology
National Central University
2020
National Chi Nan University
2016
University of Illinois Chicago
2008-2011
McGill University
1994-2008
Washington University in St. Louis
1994
In the absence of E1B, 289-amino acid product human adenovirus type 5 13S E1A induces p53-independent apoptosis by a mechanism that requires viral E4 gene products (Marcellus, R.C., J.C. Teodoro, T. Wu, D.E. Brough, G. Ketner, G.C. Shore, and P.E. Branton. 1996. J. Virol. 70:6207–6215) involves includes activation caspases (Boulakia, C.A., Chen, F.W. Ng, J.G. Branton, D.W. Nicholson, G.G. Poirier, Shore. Oncogene. 12:529–535). Here, we show one products, E4orf4, is highly toxic upon...
The inflammatory response is thought to play important roles in tissue healing. hypothesis of this study was that the cytokine interferon (IFN)-gamma produced endogenously following skeletal muscle injury and promotes efficient We show IFN-gamma expressed at both mRNA protein levels injury, time course expression correlated with accumulation macrophages, T-cells, natural killer cells, as well myoblasts, damaged muscle. Cells each type were isolated from injured muscle, detected cell type....
Bcl-2 is an integral membrane protein that functions as a suppressor of programmed cell death.It contains COOH-terminal signal anchor sequence selective for import and insertion into the mitochondrial outer and, by different mechanism, can also direct to other sites.Deletion rendered cytosolic impaired its ability prevent apoptotic death human KB cells infected with mutant form adenovirus type 5 does not make E1B 19-kDa protein.When predicted transmembrane domain was replaced yeast protein,...
In this study, we developed curcumin-encapsulated hyaluronic acid-polylactide nanoparticles (CEHPNPs) to be used for liver fibrosis amelioration. CD44, the acid (HA) receptor, is upregulated on surface of cancer cells and activated hepatic stellate (aHSCs) rather than normal cells. CEHPNPs could bind CD44 internalized effectively through endocytosis release curcumin, a poor water-soluble protective agent. Thus, were potentially not only improving drug efficiency, but also targeting aHSCs. HA...
Abstract Macrophages (Mp) and the plasminogen system play important roles in tissue repair following injury. We hypothesized that Mp-specific expression of urokinase-type activator (uPA) is sufficient for Mp to migrate into damaged muscle efficient regeneration. generated transgenic mice expressing uPA only Mp, we assessed ability these Mp-only was induce wild-type levels accumulation, angiogenesis, new fiber formation. In with expression, overexpression further increased accumulation...
BRAF inhibitors were approved for the treatment of BRAF-mutant melanoma. However, most patients acquire resistance to after several months treatment. miR-524-5p is considered as a tumor suppressor in many cancers, including In this study, we investigated biological functions melanoma with acquired inhibitor and evaluated endogenous expression biomarker The results showed that was 0.481-fold lower tissues (n = 117) than nevus 40). Overexpression significantly reduced proliferative,...
The rat carbamyl phosphate synthetase I gene is expressed in two cell types: hepatocytes and epithelial cells of the intestinal mucosa. proximal promoter contains a single activating element, GAG, repressor elements (sites III) an anti-repressor element (site II). Although these together exhibit potential for complex regulation, they are unable to confer tissue-specific activity. Here we have identified cell-type-specific enhancer that lies 10 kilobases upstream promoter. Unexpectedly, also...