A5086736499- Cancer-related gene regulation
- Complement system in diseases
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- MicroRNA in disease regulation
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Blood groups and transfusion
- Metal-Organic Frameworks: Synthesis and Applications
- Silk-based biomaterials and applications
- RNA regulation and disease
- Renal Diseases and Glomerulopathies
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Iron Metabolism and Disorders
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Covalent Organic Framework Applications
- Phagocytosis and Immune Regulation
University of Kansas Medical Center
2021-2025
Institute of Reproductive Medicine
2025
University of Alabama at Birmingham
2018-2023
National Central University
2014-2020
// Szu-Mam Liu 1 , Jean Lu 2 Hoong-Chien Lee 1,3,4 Feng-Hsiang Chung 1,3 and Nianhan Ma Institute of Systems Biology Bioinformatics, National Central University, Jhongli, Taiwan Genomics Research Center, Academia Sinica, Taipei, 3 Center for Dynamical Biomarkers Translational Medicine, 4 Department Physics, Yuan Christian Correspondence: Ma, email: Keywords : miR-524-5p, melanoma, BRAF, ERK2, MAPK signaling, microRNA Received June 20, 2014 Accepted September 08, Published Abstract It has...
Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting integrity framework. Notably, for first time, correlations between functionality cytotoxicity are also demonstrated via in vitro assays. The positive charged aminated-ZIF-90 presumably results either perturbation cell membrane, more efficient uptake, or both. Therefore, half-maximal effective (EC50 ) concentration has...
BACKGROUND: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, 13), primarily synthesized in hepatic stellate endothelial cells, plays a pivotal role the regulation of hemostasis by proteolytic cleavage von Willebrand factor. Severe deficiency plasma activity may result thrombotic thrombocytopenic purpura, potentially fatal blood disorder. undergoes posttranslational modifications including glycosylation, citrullination, oxidation. The present study determines...
Copious expression of protein arginine methyltransferase 1 (PRMT1) is associated with poor survival in many types cancers, including acute myeloid leukemia. We observed that a specific megakaryocytic leukemia (AMKL) cell line (6133) derived from RBM15-MKL1 knock-in mice exhibited heterogeneity Prmt1 levels. Interestingly, only subpopulation 6133 cells expressing high levels caused when transplanted into congenic mice. The PRMT1 inhibitor, MS023, effectively cured this PRMT1-driven Seahorse...
Copious expression of protein arginine methyltransferase 1 (PRMT1) is associated with poor survival in many types cancers, including acute myeloid leukemia. We observed that a specific megakaryocytic leukemia (AMKL) cell line (6133) derived from RBM15-MKL1 knock-in mice exhibited heterogeneity Prmt1 levels. Interestingly, only subpopulation 6133 cells expressing high levels caused when transplanted into congenic mice. The PRMT1 inhibitor, MS023, effectively cured this PRMT1-driven Seahorse...
Mutations in 5’-untranslated region (5’-UTR) of ANKRD26 (ankyrin repeat domain-containing protein 26) are associated with hereditary thrombocytopenia-2 (THC2). However, the causative role these mutations and mechanisms underlying THC2 not fully established. Here, we report for first time that zebrafish carrying a deletion two nucleotides (Δ2) 5’-UTR ankrd26 recapitulate some key laboratory features THC2. Ankrd26ku6 (homozygous Δ2 5’-UTR) fish larvae exhibited significantly increased...
Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which tightly regulated during cell differentiation.Using knockdown screening and single-cell transcriptional analysis, we demonstrate that DUSP4 is phosphatase specifically inactivates p38 kinase to promote megakaryocyte (Mk) differentiation.Mechanistically, PRMT1-mediated methylation triggers its ubiquitinylation an E3 ligase HUWE1.Interestingly, mechanistic axis...
100 nm ZIF-90 nanoparticles with low cytotoxicity are obtained by utilizing glycerol for the control of viscosity effects in water–alcohol-based system.
Abstract Cancer stem cells (CSCs), or cancer with cell-like properties, generally exhibit drug resistance and have highly potent inducing capabilities. Genome-wide expression data collected at public repositories over the last few years provide excellent material for studies that can lead to insights concerning molecular functional characteristics of CSCs. Here, we conducted genomic CSC based on fourteen PCA-screened high quality whole genome gene datasets and, as control, four non-stem-like...
BRAF inhibitors were approved for the treatment of BRAF-mutant melanoma. However, most patients acquire resistance to after several months treatment. miR-524-5p is considered as a tumor suppressor in many cancers, including In this study, we investigated biological functions melanoma with acquired inhibitor and evaluated endogenous expression biomarker The results showed that was 0.481-fold lower tissues (n = 117) than nevus 40). Overexpression significantly reduced proliferative,...
Background: Plasma levels of von Willebrand factor (VWF) are significantly elevated in patients with coronavirus disease 2019 (COVID-19). However, dynamic changes and prognostic value this biomarker hospitalized COVID-19 have not been determined. Methods: A total 124 infected SARS-CoV-2 were prospectively recruited for the study. Serial blood samples obtained at time admission (D1), 3–4 days following standard-care treatments (D2), 1–2 prior to discharge or any collected death (D3). VWF...
Background: Plasma levels of von Willebrand factor (VWF) are significantly elevated in patients with COVID-19. However, the dynamic changes and prognostic value this biomarker hospitalized COVID-19 not determined. Methods: 124 infected SARS-CoV2 were prospectively recruited for study. Serial blood samples obtained at time admission (D1), 3-4 days following standard care treatments (D2), 1-2 prior to discharge or death (D3). VWF antigen, ADAMTS13 antigen activity, as well ratio VWF/ADAMTS13...
Dynamic regulation of histone modification enzymes such as PRMT1 (protein arginine methyltransferase 1) determines the ordered epigenetic transitions in hematopoiesis. Sorting cells according to expression levels may further define subpopulations hematopoietic lineages with unique differentiation potentials that are presently defined by surface markers. We discovered a vital near infrared dye, E84, fluoresces brightly following binding and excitation red laser. The staining intensity...
Abstract Copious expression of protein arginine methyltransferase 1 (PRMT1) is associated with poor survival in many types cancers, including acute myeloid leukemia. We observed that a specific megakaryocytic leukemia (AMKL) cell line (6133) derived from RBM15-MKL1 knock-in mice exhibited heterogeneity Prmt1 levels. Interestingly, only subpopulation 6133 cells expressing high levels caused when transplanted into congenic mice. The PRMT1 inhibitor, MS023, effectively cured this PRMT1-driven...
Antibody-mediated inhibition of von Willebrand factor (VWF) cleavage by ADAMTS-13 results in immune thrombotic thrombocytopenic purpura (iTTP). However, the effects multiple antibody binding to are not fully understood.
Ovarian cancer (OC) is a highly lethal gynecological malignancy. Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. In this study, we aim to leverage these changes as potential biomarkers for assessing ovarian cancer.A functional module-based approach was utilized identify key gene expression pathways distinguish different stages of within tissue biopsy cohort. This cohort consisted control samples (n = 79), stage I/II 280), and III/IV...