A5016445495- Complement system in diseases
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Iron Metabolism and Disorders
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Diversity and Career in Medicine
- Blood groups and transfusion
- Trace Elements in Health
- Renal Diseases and Glomerulopathies
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
- Cancer-related gene regulation
- Conferences and Exhibitions Management
- Blood transfusion and management
- Trypanosoma species research and implications
- Hemophilia Treatment and Research
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Hemoglobinopathies and Related Disorders
- Biochemical and Structural Characterization
- Social Media in Health Education
- Adenosine and Purinergic Signaling
Versiti Blood Center of Wisconsin
2025
Oklahoma State University Center for Health Sciences
2021-2024
Washington University in St. Louis
2011-2020
Kenya Agricultural Research Institute
2015
Western Michigan University
2008-2010
Respiratory tract infections (RTIs) caused by bacteria or viruses are associated with stroke severity. Recent studies have revealed an imbalance in the von Willebrand factor (VWF)-ADAMTS13 axis patients RTIs, including COVID-19. We examined whether this contributes to RTI-mediated Wild-type (WT), Vwf −/−, Adamts13−/− mice respective littermate controls (Vwf +/+, Adamts13+/+) were infected intranasally sublethal doses of S. aureus (on days 0, 2, and 5) mouse-adapted SARS-CoV-2 day 0)...
Significance The blood protein von Willebrand factor (VWF) is required for platelets to stop bleeding at sites of injury, and the metalloprotease ADAMTS13 limits platelet adhesion by cleaving VWF only when flowing stretches it, especially within a growing thrombus. This feedback inhibition essential because deficiency causes fatal microvascular thrombosis. How recognizes so specifically not understood. We now find that folded roughly in half its distal domains inhibit domain. relieves this...
Youth cherish technology, efficiency and innovations accommodate entrepreneurial risks. The objectives of this study were to show the beneficial use Information Communication Technologies (ICTs) in agriculture among youth Kenya, assessed ICT application commonly used tools, experienced challenges, impacts suggested future use. Beneficial applications exemplified by 'Mkulima Young Champions' who led digital initiatives, drew into farming, helped them learn themselves, traded overcame...
Background: Preceding respiratory tract infections (RTIs) caused by bacteria or viruses are associated with worse stroke outcomes, likely due to an exaggerated inflammatory immune response, endothelial dysfunction, platelet activation, and coagulopathy. Recent studies have revealed increased plasma von Willebrand factor (VWF) levels reduced ADAMTS13 activity (the risk factors for stroke) in patients RTIs, including COVID-19. However, it remains unclear whether imbalance the VWF–ADAMTS13 axis...
BACKGROUND: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, 13), primarily synthesized in hepatic stellate endothelial cells, plays a pivotal role the regulation of hemostasis by proteolytic cleavage von Willebrand factor. Severe deficiency plasma activity may result thrombotic thrombocytopenic purpura, potentially fatal blood disorder. undergoes posttranslational modifications including glycosylation, citrullination, oxidation. The present study determines...
Abstract Trauma-induced organ failure is characterized by endothelial dysfunction. The aim of this study was to investigate the role von Willebrand factor (VWF) and its cleaving enzyme, ADAMTS13 (a disintegrin metalloproteinase with thrombospondin type 1 motifs, member 13) in occurrence permeability trauma. In an observational a level-1 trauma center, 169 adult patients clinical signs shock and/or severe injuries were included. Trauma associated low high VWF antigen levels, thus generating...
As a result of the coronavirus disease 2019 pandemic, International Society on Thrombosis and Haemostasis (ISTH), like many societies around world, canceled their in-person hematology congress planned for Milan, Italy, in July 2020. result, first virtual ISTH organisation's 51-year history was delivered, inviting free registration from across globe. part social media support, marketing, scientific dissemination efforts congress, assembled group official Twitter Ambassadors, which represented...
The term "early career professional" (ECP) indicates a generation of professionals that demonstrates the potential to succeed established and leaders. field thrombosis hemostasis has large ECP community. They often face typical challenges in their endeavor establish an independent academic career. A healthy work‐life balance mentoring are key for ECPs create ideal circumstances advance careers. However, multitasking training, research clinical duties is burden, burnout looming issue. advent...