A5043994456- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood transfusion and management
- Sepsis Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Hemostasis and retained surgical items
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobin structure and function
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Pelvic and Acetabular Injuries
- Heparin-Induced Thrombocytopenia and Thrombosis
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory Support and Mechanisms
Erasmus University Rotterdam
2022-2025
Erasmus MC
2022-2025
University of Amsterdam
2019-2025
Amsterdam University Medical Centers
2019-2025
European Society of Intensive Care Medicine
2022
Amsterdam UMC Location University of Amsterdam
2015
Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent treat coagulopathy. We aimed determine whether augmenting MHPs with Viscoelastic Haemostatic Assays (VHA) would improve outcomes compared Conventional Coagulation Tests (CCTs).This was a multi-centre, randomized controlled trial comparing in patients who received empiric MHPs, augmented by either VHA or CCT-guided interventions. Primary outcome the proportion subjects who,...
Background The dysregulated immune response during sepsis involves endothelial injury, which may be augmented by infusion of clear fluids such as crystalloids. Plasma has been suggested an alternative resuscitation fluid but it is unclear whether previously observed benefits were due to the type fluid, or less volume required restore tissue perfusion. We hypothesized that with plasma reduces inflammation, and organ injury compared similar higher volumes crystalloids in a rat pneumosepsis...
Severe trauma affects the immune system, which in its turn is associated with poor outcome. The mediators driving responses are largely unknown. aim of this study was to investigate role endogenous microparticles (MPs) mediating response following severe trauma.A prospective, observational substudy ACIT II (Activation Coagulation and Inflammation Trauma II) performed at our academic level I center. Adult multiple-trauma patients an injury severity score 15 or higher were included between May...
Abstract Trauma-induced organ failure is characterized by endothelial dysfunction. The aim of this study was to investigate the role von Willebrand factor (VWF) and its cleaving enzyme, ADAMTS13 (a disintegrin metalloproteinase with thrombospondin type 1 motifs, member 13) in occurrence permeability trauma. In an observational a level-1 trauma center, 169 adult patients clinical signs shock and/or severe injuries were included. Trauma associated low high VWF antigen levels, thus generating...
Background Viscoelastic hemostatic assays such as rotational thromboelastometry (ROTEM) are used to guide treatment of trauma induced coagulopathy. The authors hypothesized that ROTEM derangements reflect specific coagulation factor deficiencies after trauma. Methods This was a secondary analysis prospective cohort study in six European centers patients presenting with full team activation. Patients dilutional coagulopathy and on anticoagulants were excluded. Blood drawn arrival for...
Abstract Background Cryopreserved platelet products can be stored for years and are mainly used in military settings. Following thawing, cryopreserved platelets activated, resulting faster clot formation but reduced aggregation vitro, rendering their efficacy bleeding unknown. Also, concerns remain on the safety of these products. The aim was to investigate a rat model traumatic hemorrhage. Study Design Methods After 1 hour shock, rats (n = 13/group) were randomized receive balanced...
Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present different coagulation defects. In this study, the aim was to determine effect of shock duration on characteristics. We hypothesized that longer leads more hypocoagulable rotational thromboelastometry (ROTEM) profile compared shorter shock.Male B57BL/6J(c) mice (n = 5-10 per group) were sedated mechanically ventilated. Trauma induced by bilateral lower limb fractures...
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus standard 1:1 on transfusion requirements, correction TIC, and organ damage rat multiple trauma model. Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury small intestine liver fracture femur, followed exsanguination until mean arterial pressure (MAP) 40 mmHg. Animals...
As a result of improvements in the early resuscitation phase trauma, mortality is largely driven by later due to multiple organ dysfunction syndrome (MODS), which may be mediated an overdrive host immune response. If patients at risk for MODS could identified early, preventive treatment measures taken. The aim this study investigate whether specific biomarkers are associated with MODS.Multiple trauma presenting Amsterdam University Medical Centers, location Academic Center, between 2012 and...
Bleeding is a leading cause of perioperative mortality [1].In setting, damage control surgery with massive transfusion protocols (MTPs) are therapeutic approaches used clinically to manage patients major bleeding.Massive arbitrarily defined as receiving 10 or more red blood cell units in 24 h.MTPs include components whole blood, along coagulation factor concentrates, including prothrombin complex concentrates (PCCs) and fibrinogen, often based on bleeding management algorithm that may...
Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation septic patients with crystalloids is associated aggravation endothelial permeability, which may be related either to low protein content or volume. We investigated whether initial different types plasma albumin decreases dysfunction organ in pneumosepsis rat model compared the same volume crystalloids. Sprague-Dawley rats were intratracheally inoculated Streptococcus pneumoniae. Twenty-four hours after...
BackgroundTrauma-induced shock is associated with endothelial dysfunction. We examined whether the tyrosine kinase inhibitor bosutinib as an adjunct therapy to a balanced blood component resuscitation strategy reduces trauma-induced permeability, thereby improving reversal and limiting transfusion requirements organ failure in rat polytrauma model.MethodsMale Sprague–Dawley rats (n=13 per group) were traumatised exsanguinated until MAP of 40 mm Hg was reached, then randomised two groups: red...
Septic shock is characterized by endothelial dysfunction, leading to tissue edema and organ failure. Heparan sulfate (HS) essential for vascular barrier integrity, possibly via albumin as a carrier. We hypothesized that supplementing fluid resuscitation with HS would improve function, thereby reducing injury in rat pneumosepsis model. Following intratracheal inoculation Streptococcus pneumoniae, Sprague Dawley rats were randomized fixed volume of either Ringer’s Lactate (RL, standard care),...
INTRODUCTION Female sex may provide a survival benefit after trauma, possibly attributable to protective effects of estrogen. This study aimed compare markers coagulation between male and female trauma patients across different ages. METHODS Secondary analysis prospective cohort that was conducted at six centers. Trauma presenting with full team activation were eligible for inclusion. Patients penetrating or traumatic brain injury excluded. Upon hospital arrival, blood drawn measurement...
Abstract Background Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present different coagulation defects. In this study, the aim was to determine effect of shock duration on characteristics. We hypothesized that longer leads more hypocoagulable rotational thromboelastometry (ROTEM) profile compared shorter shock. Methods| Male B57BL/6J(c) mice (n=5 10 per group) were sedated mechanically ventilated. Trauma induced by...