A5062584828- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Blood transfusion and management
- Abdominal Trauma and Injuries
- Intensive Care Unit Cognitive Disorders
- Blood donation and transfusion practices
- Vagus Nerve Stimulation Research
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Hemoglobin structure and function
- Hemostasis and retained surgical items
- Cardiac Arrest and Resuscitation
- Blood Coagulation and Thrombosis Mechanisms
- Muscle and Compartmental Disorders
- Erythrocyte Function and Pathophysiology
- Radiation Dose and Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Inhalation and Respiratory Drug Delivery
- Acute Kidney Injury Research
Amsterdam University Medical Centers
2019-2022
University of Amsterdam
2020-2022
Amsterdam UMC Location University of Amsterdam
2013-2020
OLVG
2020
Contemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent treat coagulopathy. We aimed determine whether augmenting MHPs with Viscoelastic Haemostatic Assays (VHA) would improve outcomes compared Conventional Coagulation Tests (CCTs).This was a multi-centre, randomized controlled trial comparing in patients who received empiric MHPs, augmented by either VHA or CCT-guided interventions. Primary outcome the proportion subjects who,...
Essentials The response of thromboelastometry (ROTEM) parameters to therapy is unknown. We prospectively recruited hemorrhaging trauma patients in six level-1 centres Europe. Blood products and pro-coagulants prevent further derangement ROTEM results. algorithms can be used treat monitor induced coagulopathy. SUMMARY: Background Rotational detect trauma-induced coagulopathy (TIC) transfusion algorithms. Objectives To determine the profiles bleeding patients. Patients/Methods A prospective...
Both trauma-induced coagulopathy (TIC) and transfusion strategies influence early outcome in hemorrhagic trauma patients. Their impact on late is less well characterized. This study systematically reviews risk factors for TIC- transfusion-associated multiple organ failure (MOF) severely injured patients.A systematic search was conducted PubMed Embase. Studies published from 1986 to 2013 adult patients with an injury severity score ≥16, investigating TIC or MOF as primary secondary outcome,...
Transfusion is associated with organ failure and nosocomial infection in trauma patients, which may be mediated by soluble bioactive substances blood products, including extracellular vesicles (EVs). We hypothesize that removing EVs, washing or filtering of reduces improves host immune response.Blood products were prepared from syngeneic rat blood. EVs removed RBCs platelets washing. Plasma was filtered through a 0.22-μm filter. Rats traumatized crush injury to the intestines liver, femur...
Abstract Purpose Nosocomial infection contributes to adverse outcome after brain injury. This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients following stroke or traumatic injury (TBI). Methods A prospective was performed adult TBI who were admitted the Intensive Care Unit of our tertiary university hospital between 2013 and 2016. Heart rate variability (HRV) recorded daily assessed for activity. Outcomes nosocomial...
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus standard 1:1 on transfusion requirements, correction TIC, and organ damage rat multiple trauma model. Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury small intestine liver fracture femur, followed exsanguination until mean arterial pressure (MAP) 40 mmHg. Animals...
Objectives Trauma-induced hemorrhagic shock is characterized by increased endothelial permeability and coagulopathy. Vasopressin analog ddAVP (desmopressin) acts reorganizing redistributing adhesive tight junction molecules, enhancing barrier function. Furthermore, increases von Willebrand factor (vWF) plasma levels thereby potentially enhances platelet-based coagulation. The objective of this study was to assess whether the use results in improvement both function coagulation, improving...
Abstract Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, obstruction microcirculation and injury, aggravating bleeding, as well contributing to organ failure. Under normal conditions, vWF cleaved by metalloprotease ADAMTS-13. After trauma, ADAMTS-13 levels are reduced. Objectives To assess whether recombinant human inhibits injury failure a rat...
Endotheliopathy following trauma is associated with poor outcome, but the underlying mechanisms are unknown. This study hypothesized that an increased extracellular vesicle (EV) concentration endotheliopathy after and red blood cell (RBC) transfusion could further enhance endotheliopathy. In this post hoc sub of a multicentre observational trial, 75 patients were stratified into three groups based on injury severity score or shock. patient plasma obtained at hospital admission four RBC...
Abstract Purpose: Nosocomial infection contributes to adverse outcome after brain injury. This study investigates whether autonomic nervous system activity is associated with a decreased host immune response in patients following stroke or traumatic injury (TBI). Methods: A prospective was performed adult TBI who were admitted the Intensive Care Unit of our tertiary university hospital between 2013 and 2016. Heart rate variability (HRV) recorded daily assessed for activity. Outcomes...
Background and Objectives Red‐blood‐cell (RBC) transfusion is associated with lung injury, which further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally may play a role in the induction pulmonary cell activation through alteration immunomodulatory property products. Here, effect different manufacturing on was investigated an vitro model Materials Methods Pulmonary type II cells were incubated supernatant from fresh old RBC obtained via whole...