A5100664846- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Horticultural and Viticultural Research
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Berberine and alkaloids research
- Pneumonia and Respiratory Infections
- Vascular Tumors and Angiosarcomas
- Cellular transport and secretion
- Cardiac tumors and thrombi
- Cytokine Signaling Pathways and Interactions
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Organ and Tissue Transplantation Research
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Amyotrophic Lateral Sclerosis Research
- Polyomavirus and related diseases
Chongqing Medical University
2023-2025
China Agricultural University
2025
Tongji Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Wuhan University
2022-2024
Renmin Hospital of Wuhan University
2022-2024
Xuzhou Medical College
2024
East China Normal University
2022-2024
Union Hospital
2024
Jilin University
2022-2024
Abstract The power conversion efficiency (PCE) of perovskite solar cells (PSCs) is approaching their Shockley‐Queisser (S‐Q) limit through numerous efforts in key parameters improvement. To further the limit, it important to facilitate fill factor (FF), a parameter closely related carrier transport and nonradiative recombination. Herein, an interfacial bridging strategy proposed improve FF, which utilizes functional graphene quantum dots at tin oxide (SnO 2 )/perovskite buried interface. As...
Importance Bietti crystalline dystrophy (BCD) is a severe genetic retinopathy caused by variants in the CYP4V2 gene. Currently, there no approved treatment for BCD. Objective To evaluate safety and vision outcomes following gene therapy with adeno-associated virus (AAV) encoding (rAAV-hCYP4V2, NGGT001 [Next Generation Gene Therapeutics]). Design, Setting, Participants This open-label, dose-escalation nonrandomized clinical trial was conducted from February 2023 to May 2024 at 2 study sites...
In this study, we developed curcumin-encapsulated hyaluronic acid-polylactide nanoparticles (CEHPNPs) to be used for liver fibrosis amelioration. CD44, the acid (HA) receptor, is upregulated on surface of cancer cells and activated hepatic stellate (aHSCs) rather than normal cells. CEHPNPs could bind CD44 internalized effectively through endocytosis release curcumin, a poor water-soluble protective agent. Thus, were potentially not only improving drug efficiency, but also targeting aHSCs. HA...
Abstract Dominant mutations in the mitochondrial paralogs coiled-helix-coiled-helix (CHCHD) domain 2 (C2) and CHCHD10 (C10) were recently identified as causing Parkinson’s disease amyotrophic lateral sclerosis/frontotemporal dementia/myopathy, respectively. The mechanism by which they disrupt cristae, however, has been uncertain. Using first C2/C10 double knockout (DKO) mice, we report that C10 pathogenesis normal function of are intimately linked. Similar to patients with mutations, found...
Abstract Background Lipid accumulation product (LAP) and cardiometabolic index (CMI) are two novel obesity-related indexes associated with enhancing metabolic disease (MD) risk. Current evidences suggest that the differences in sex hormones regional fat distribution both sexes directly correlated MD nonalcoholic fatty liver (NAFLD) Hence, NAFLD incidences reflect differences. Herein, we examined accuracy of LAP CMI diagnosing sexes. Methods Overall, 14,407 subjects, who underwent health...
GTRAP3-18 interacts with and reduces the activity of neuronal specific Na(+)/K(+) glutamate transporter, EAAC1 both in vitro vivo. related isoform, JM4, are distant relatives Rab GTPase-interacting factor PRA1, share a topology four transmembrane domains cytosolic termini. JM4 resident endoplasmic reticulum (ER) proteins. The physiological role is poorly understood. We demonstrate for first time that regulator ER protein trafficking. Expression delays exit EAAC1, as well other members...
To investigate the difference of retinal nerve fiber layer (RNFL) thickness between Alzheimer's disease patients and normal people, so as to provide clue for early diagnosis disease.The articles on association RNFL were retrieved by searching international national databases. The qualified assessed meta analysis with Stata11.0 software. results pooled using weighted mean (WMD) a corresponding 95% confidence interval (CI).Totally 7 studies enrolled 324 eyes included in meta-analysis. showed...
Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal dominant Parkinson Disease (PD) Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS/FTD), respectively. Using newly generated CHCHD2, CHCHD2/10 double knockout cell lines, we find that the are partially functionally redundant, similarly distributed throughout cristae, form heterodimers. Unexpectedly, also CHCHD2/CHCHD10 heterodimerization increases response to stress. This increase is driven by...
Introduction and aims. The association between thyroid function non-alcoholic fatty liver disease (NAFLD) remained controversial. A large cross-sectional study aimed to explore the relationship in euthyroid population. Material methods. total of 1773 subjects who underwent health check-up during one-year period were enrolled. NAFLD was diagnosed by ultrasound index (FLI). Fibrosis estimated BARD score. Thyroid parameters, including thyroid-stimulating hormone (TSH), free triiodothyronine...
Objectives This study aimed to assess left atrial (LA) size in healthy cats using cardiovascular MRI (cMRI) and compare this with LA assessed by two-dimensional echocardiography. The hypothesis was that cMRI would accurately determine domestic cats. Methods A prospective comparative performed. Six were selected for the study. Standard echocardiography performed without general anaesthesia. conducted under comprehensive analysis of mass function measurements consistency correlation indicators...
The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development rational combination therapies based on hyperthermia (HT). This study reports preliminary results neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response high-grade serous with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within microenvironment....
<title>Abstract</title> <bold>Background: </bold>Age-related hearing loss (ARHL) is a prevalent progressive that can lead to emotional impairment and cognitive decline in older adults. The aim of this study was investigate the epidemiologic characteristics ARHL from 1990 2021. <bold>Methods: </bold>We collected data elderly using National Health Nutrition Examination Survey (NHANES) database 2005 2018. Prevalence disability-adjusted life years (DALYs) for were obtained Global Burden Disease...
A specific polymorphism in the hemochromatosis (HFE) gene, H63D, is over-represented neurodegenerative disorders such as amyotrophic lateral sclerosis and Alzheimer disease. Mutations of HFE are best known being associated with cellular iron overload, but mechanism by which H63D might increase risk neuron degeneration unclear. Here, using an inducible expression cell model developed from a human neuronal line SH-SY5Y, we reported that presence protein activated unfolded response (UPR). This...
Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an essential role in modulating inflammatory responses and extracellular matrix remodeling.However, little is known regarding the of TSG-6 human cancers.Here, we investigated mechanism action colorectal cancer (CRC) metastasis.We found that was highly expressed tumor tissues associated with poor prognosis metastasis CRC.Mechanistically, overexpression CRC cells resulted ERK activation epithelial-mesenchymal...
Abstract Background Studies have shown that miR-502-5p functions as a tumor suppressor and is associated with growth metastasis. This study intends to uncover the potential mechanism of functioning in gastric cancer. Methods Expression levels PD-L1 were measured by using qRT-PCR. Cell proliferation abilities examined EDU incorporation assay. migration, invasion cell cycle analysis cells determined transwell assay, transwell-matrigel assay flow cytometry, respectively. The relationship...
Selective cargo capture into ER-derived vesicles is driven by the Sec24p subunit of COPII coat, which contains at least three independent cargo-binding sites. One these, "A-site," interacts with a NPF motif found on SNARE, Sed5p. We have characterized Sec24p-Sed5p interaction through mutation putative ER export motifs Sed5p and A-site Sec24p. Mutational analysis suggests that dominant signal. Mutation binding pocket led to dramatic reduction in vesicles, whereas packaging other ER-Golgi...