A5048543773- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Renal and related cancers
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- DNA Repair Mechanisms
- RNA Research and Splicing
Tongji Hospital
2022-2025
Huazhong University of Science and Technology
2022-2025
Hyperthermic intraperitoneal chemotherapy's role in ovarian cancer remains controversial, hindered by limited understanding of hyperthermia-induced tumor cellular changes. This limits developing potent combinatory strategies anchored hyperthermic therapy (HIPET). Here, we perform a comprehensive multi-omics study on cells under hyperthermia, unveiling distinct molecular panorama, primarily characterized rapid protein phosphorylation Based the phospho-signature, pinpoint CDK1 kinase is...
The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development rational combination therapies based on hyperthermia (HT). This study reports preliminary results neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response high-grade serous with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within microenvironment....
Although resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) has gradually become a major challenge in the maintenance therapy for high-grade serous ovarian carcinoma (HGSOC), there are no universal indicators monitoring patients. A key mechanism PARPi is restoration of homologous recombination repair (HRR), including BRCA reversion mutations and changes DNA damage proteins. To explore mutation profiles associated with resistance, we undertook targeted 42-gene deep sequencing...
Ovarian cancer (OC) manifests as a complex disease characterized by inter- and intra-patient heterogeneity. Despite enhanced biological genetic insights, OC remains recalcitrant malignancy with minimal survival improvement. Based on multi-site sampling multi-lineage patient-derived xenograft (PDX) establishment strategy, we present herein the of comprehensive PDX biobank from histologically molecularly heterogeneous patients. Comprehensive profiling matched patient samples demonstrates that...
Ovarian serous carcinoma (OC) is a common cause of mortality among gynecological malignancies. Although tumor‑infiltrating CD8 T cells are associated with favorable prognosis OC, the underlying mechanisms not clearly understood. The present study identified key genes and potential molecular T‑cell infiltration in OC. score Cancer Genome Atlas dataset (376 samples from patients OC) was estimated using quanTIseq MCP‑counter algorithms. Thereafter, protein‑protein interaction network...
Abstract Background Although the clinical application of PARP inhibitors has brought hope to ovarian cancer, problem its resistance become increasingly prominent. Therefore, experts have been focused on finding specific indicators and therapeutic targets that can be used for monitoring inhibitors. Results By cfDNA detecting during Olaparib maintenance therapy in platinum-sensitive relapsed we found presence MRE11:p.K464R mutation was strongly associated with acquired resistance. Structural...
Abstract Endometrial carcinoma (EC) remains a public health concern with growing incidence particularly in younger women. Women early-onset endometrioid EC (EEEC) who wish to maintain fertility are worldwide concern. To illuminate the molecular characteristics of EEEC, we undertook large-scale proteogenomic study 222 EECs encompassing 81 EEEC were 40 or younger. In contrast late-onset EEC, integrated multi-omics analysis unexpectedly revealed an exposome-related mutational signature be...
Abstract Cervical cancer ranks as the fourth leading cause of cancer-related deaths among women, with low response rates to immune-checkpoint blockade (ICB). Here we conducted a multidimensional analysis encompassing single-cell RNA-seq (scRNA-seq), spatial transcriptomics, and proteomics, combined genetic pharmacological perturbations systematically develop high-resolution spatially-resolved map intra-tumoral expression heterogeneity in cervical squamous cell carcinoma (CSCC). Three...