A5101899494- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Protein Degradation and Inhibitors
- Melanoma and MAPK Pathways
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Reproductive tract infections research
- Barrier Structure and Function Studies
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Global Cancer Incidence and Screening
- Long-Term Effects of COVID-19
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
National Clinical Research
2020-2021
Wuhan University
2014-2018
Qingdao University
2010-2012
Although research on the effects of comorbidities coronavirus disease 2019 (COVID-19) patients is increasing, risk cancer history has not been evaluated for mortality with COVID-19.In this retrospective study, we included 3232 pathogen-confirmed COVID-19 who were hospitalized between January 18th and March 27th, 2020, at Tongji Hospital in Wuhan, China. Propensity score matching was used to minimize selection bias.In total, 2665 complete clinical outcomes analyzed. The impacts age, sex,...
Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, represent a favorable prognostic factor in high-grade serous ovarian cancer (HGSOC) and other tumor lineages. Here, we analyze the spatial heterogeneity of different TIL subtypes HGSOC. We integrated RNA sequencing, whole-genome bulk T cell receptor (TCR) as well single-cell RNA/TCR sequencing to investigate characteristics differential composition TILs across HGSOC sites. Two immune "cold" patterns are identified: (1) lesions with...
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion transcripts. Herein, we demonstrate only productive were nonrandomly distributed across both viral and host genomes, suggesting are under selection likely contribute CC pathophysiology. Furthermore, using large-scale, multi-omics (clinical, genomic,...
The understanding of viral positivity and seroconversion during the course coronavirus disease 2019 (COVID-19) is limited.To describe patterns polymerase chain reaction (PCR) evaluate their correlations with severity.Retrospective cohort study.3 designated specialty care centers for COVID-19 in Wuhan, China.3192 adult patients COVID-19.Demographic, clinical, laboratory data.Among 12 780 reverse transcriptase PCR tests severe acute respiratory syndrome 2 that were done, 24.0% had positive...
The characteristics of COVID-19 patients with persistent SARS-CoV-2 infection are not yet well described. Here, we compare the clinical and molecular features long duration viral shedding (LDs) those from short (SDs), healthy donors (HDs). We find that several cytokines chemokines, such as interleukin (IL)-2, tumor necrosis factor (TNF) lymphotoxin α (LT-α) present at lower levels in LDs than SDs. Single-cell RNA sequencing shows natural killer (NK) cells CD14+ monocytes reduced, while...
Targeted therapies represent attractive combination partners with immune checkpoint blockade (ICB) to increase the population of patients who benefit or interdict emergence resistance. We demonstrate that targeting WEE1 up-regulates signaling through double-stranded RNA (dsRNA) viral defense pathway subsequent responsiveness even in cGAS/STING-deficient tumors, which is a typical phenotype across multiple cancer types. inhibition increases endogenous retroviral elements (ERVs) expression by...
Abstract Mutant KRAS tumors are associated with poor outcomes, at least in part, due to decreased therapeutic sensitivity. Here, we show that mutations resistance monotherapy and combination therapy PARP inhibitors (PARPi) immune checkpoint blockade anti–PD-L1 antibodies. In mutant tumors, inhibition of signaling MEK (MEKi) triggered amplified PARPi-induced DNA damage, cytosolic double-stranded accumulation, STING pathway activation, CD8+ T-cell recruitment. Moreover, MEKi myeloid-derived...
Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that inhibitor AZD1775 induces endoplasmic reticulum stress activates protein kinase RNA-like ER (PERK) inositol-required enzyme 1α (IRE1α) branches of unfolded response (UPR) TP53 mutant (mtTP53) cancer models. This facilitated through NF-κB mediated senescence-associated...
Hyperthermic intraperitoneal chemotherapy's role in ovarian cancer remains controversial, hindered by limited understanding of hyperthermia-induced tumor cellular changes. This limits developing potent combinatory strategies anchored hyperthermic therapy (HIPET). Here, we perform a comprehensive multi-omics study on cells under hyperthermia, unveiling distinct molecular panorama, primarily characterized rapid protein phosphorylation Based the phospho-signature, pinpoint CDK1 kinase is...
The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development rational combination therapies based on hyperthermia (HT). This study reports preliminary results neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response high-grade serous with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within microenvironment....
Background Ovarian cancer (OC) is one of the most lethal gynecologic cancers. Growing evidence has proven that CDK4/6 plays a key role in tumor immunity and prognosis many However, expression function OC remain unclear. Therefore, we aimed to explore influence OC, especially on immunity. Methods We analyzed using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) Genotype Tissue (GTEx) data. Subsequently, used cytoHubba plug-in Cytoscape software starBase identify noncoding RNAs...
Vulvovaginal atrophy (VVA) is a common menopause-related symptom affecting more than 50% of midlife and older women cancer patients whose ovarian function are lost or damaged. Regardless estrogen deficiency, whether other factors such as the gut microbiota play role in VVA have not been thoroughly investigated. To this end, we performed ovariectomy on 12-weeks' old mice follow-up at 4 weeks after ovariectomy, observed atrophied vagina an altered ovariectomized mice.. We further fecal...
Cutaneous malignant melanoma is a severe and sometimes life-threatening cancer. The molecular mechanism of melanomagenesis incompletely understood. Deregulation apoptosis probably one the key factors contributing to progression melanoma. inhibitor growth (ING) family proteins are candidate tumour suppressors which play important roles in apoptosis. Downregulated expression ING have been reported several types, including loss nuclear p33ING1b As ING2 exhibits 58.9% homology with p33ING1b, we...
Junctional adhesion molecules are important components of tight junctions, and Eph/ephrin proteins constitute the largest family receptor tyrosine kinases. Both junctional involved in normal tissue development cancer progression. However, expression levels clinical significances molecule-A, a member molecules, EphB2, family, lung adenocarcinoma patients unclear. Therefore, this study, we aimed to identify prognostic values molecule-A EphB2 patients' cohort. In our 70 (55.6%) showed high...
Background Mismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies convert MMR-proficient (pMMR) dMMR phenotype with the goal of sensitizing tumors ICB are highly sought. The combination bromodomain containing 4 (BRD4) inhibition and provides promising antitumor effect. However, mechanisms underlying remain unknown. Here, we identify that BRD4 induces persistent in cancers. Methods We confirmed correlation between mismatch...
Ovarian cancer (OC) ranks first among gynecologic malignancies in terms of mortality. The benefits poly (ADP-ribose) polymerase (PARP) inhibitors appear to be limited OC with BRCA mutations. Concurrent administration WEE1 (eg, adavosertib (Ada)) and PARP olaparib (Ola)) effectively suppress ovarian tumor growth regardless mutation status, but is poorly tolerated. Henceforth, we aimed seek a strategy reduce the toxic effects this combination by taking advantage mesoporous polydopamine (MPDA)...