A5009669131- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Myasthenia Gravis and Thymoma
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Cancer, Hypoxia, and Metabolism
- Whipple's Disease and Interleukins
- Angiogenesis and VEGF in Cancer
Universitat de Barcelona
2017-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017-2025
Centre for Biomedical Network Research on Rare Diseases
2025
VIB-KU Leuven Center for Cancer Biology
2020
Universitat Autònoma de Barcelona
2017
Hospital de Sant Pau
2017
Effective and safe therapies are needed for the treatment of patients with giant cell arteritis (GCA). Emerging as a key cytokine in inflammation, granulocyte-macrophage colony stimulating factor (GM-CSF) may play role promoting inflammation GCA.
Blocking interleukin (IL)-6-receptor with tocilizumab has been a major advance in the treatment of giant-cell arteritis (GCA), supporting crucial role IL-6 receptor signalling. However, nearly half patients are not able to maintain glucocorticoid- free remission tocilizumab. The impact on vascular lesions GCA is largely unknown since conflicting results have obtained by imaging. expression and functional IL-6-receptor immunopathology previously investigated. This study aimed investigate...
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous disease in which diverse autoantibodies have been described but systematic screening has never performed. Detection of CIDP-specific antibodies may be clinically useful. We developed protocol to uncover novel reactivities CIDP. Sixty-five CIDP patients and 28 controls were included our study. Three (4.6%) had against neurofascin 155, four (6.2%) contactin-1 one (1.5%) the contactin-1/contactin-associated...
Rationale: How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. Yet, mechanisms underlying remodeling remain poorly established. A better understanding of these processes may lead to the design novel therapeutic strategies complementary current angiogenesis inhibitors. Objective: Starting from our previous observations that PP2A (protein phosphatase 2) regulates HIF (hypoxia-inducible factor)/PHD-2 (prolyl hydroxylase 2)-constituted oxygen...
Introduction The pathogenesis of Giant Cell Arteritis (GCA) relies on vascular inflammation and remodeling, the latter being poorly controlled by current treatments. Methods This study aimed to evaluate effect a novel cell therapy, Human Monocyte-derived Suppressor Cells (HuMoSC), remodeling improve GCA treatment. Fragments temporal arteries (TAs) from patients were cultured alone or in presence HuMoSCs their supernatant. After five days, mRNA expression was measured TAs proteins culture...
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) through their capacity produce chemokines recruiting T and monocytes arterial wall ability migrate proliferate neointima where they acquire myofibroblast (MF) phenotype, leading vascular stenosis. This study aimed investigate if MFs could also impact T-cell polarization. Confocal microscopy was used analyze fresh fragments temporal artery biopsies (TABs). Healthy TAB sections...