A5013290865- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Mosquito-borne diseases and control
- Retinal and Optic Conditions
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Physiological and biochemical adaptations
- Cancer, Lipids, and Metabolism
- Ophthalmology and Eye Disorders
- Hereditary Neurological Disorders
- Immunodeficiency and Autoimmune Disorders
- Spinal Dysraphism and Malformations
- Head and Neck Anomalies
- Cell Adhesion Molecules Research
- Aquaculture disease management and microbiota
- Autoimmune Bullous Skin Diseases
- Aquaculture Nutrition and Growth
Centre for Biomedical Network Research on Rare Diseases
2018-2022
Hospital de Sant Pau
2017-2022
Universitat Autònoma de Barcelona
2017-2022
John Radcliffe Hospital
2022
Centro de Investigación Biomédica en Red
2018-2021
Universitat de Barcelona
2015
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous disease in which diverse autoantibodies have been described but systematic screening has never performed. Detection of CIDP-specific antibodies may be clinically useful. We developed protocol to uncover novel reactivities CIDP. Sixty-five CIDP patients and 28 controls were included our study. Three (4.6%) had against neurofascin 155, four (6.2%) contactin-1 one (1.5%) the contactin-1/contactin-associated...
The aim of the research is to study human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies.Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included a case-control study. DRB1 HLA analyzed all while DQ only studied sharing DRB1*15 allele. In silico HLA-peptide binding NF155 antigenicity, predictions performed analyze overlap between...
Abstract Objective Paraneoplastic neurological syndromes ( PNS ) are rare disorders in which ectopic expression of neural antigens by a tumor results an autoimmune attack against the nervous system. Onconeural antibodies not only guide diagnosis but may also help detecting underlying malignancies. Our project aims to uncover new potential paraneoplastic neuropathies PN ). Methods Thirty‐four patients fulfilling diagnostic criteria possible n = 9; 26.5%) and definite 25; 73.5%) without...
Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed 1:4,000 ZIKV cases. Whether symptoms infection are immune mediated unclear. We used rodent human live cellular models to screen for anti-peripheral nerve reactive IgG IgM autoantibodies sera patients without GBS.In this study, 52 ZIKV-GBS were compared 134 ZIKV-infected GBS 91 non-ZIKV...
ABSTRACT Introduction Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurological side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed 1:4000 ZIKV cases. Whether symptoms infection are a consequence autoimmunity or direct neurotoxicity unclear. Methods We employed rat dorsal root ganglion (DRG) neurons, Schwann cells (SCs), human stem cell-derived sensory neurons myelinated SCs as cellular models...