A5102627566- Vasculitis and related conditions
- Spondyloarthritis Studies and Treatments
- Gout, Hyperuricemia, Uric Acid
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Musculoskeletal synovial abnormalities and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Sarcoidosis and Beryllium Toxicity Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Advanced X-ray and CT Imaging
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Osteomyelitis and Bone Disorders Research
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- IgG4-Related and Inflammatory Diseases
- Systemic Sclerosis and Related Diseases
- Infectious Diseases and Tuberculosis
- Spine and Intervertebral Disc Pathology
CHU Dijon Bourgogne
2018-2025
Inserm
2020-2025
Université de Bourgogne
2020-2025
Maison des Sciences de l’Homme de Dijon
2018-2024
Centre Hospitalier Universitaire de Besançon
2024
Infirmerie Protestante
2024
Université Bourgogne Franche-Comté
2021-2024
Université de franche-comté
2024
Methodology and Quality of Life Unit in Oncology
2023
Unit of Virus Host Cell Interactions
2022
To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment Janus kinase inhibitors (JAKis) using MAJIK-SFR registry. Prospective national multicentre observational study identifying patients RA-ILD from Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months a median 21 postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC)...
Abstract Objectives To investigate the performance of cranial PET/CT for diagnosis GCA. Methods All patients with a suspected GCA were prospectively enrolled in this study and had digital evaluation arteries if they not started glucocorticoids >72 h previously. The was retained after at least 6 months follow-up no other considered by clinician patient went into remission consecutive treatment. Cranial positive one arterial segment showed hypermetabolism similar to or greater than...
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are frequently overlapping conditions. Unlike in GCA, vascular inflammation is absent PMR. Therefore, serum biomarkers reflecting remodelling could be used to identify GCA cases of apparently isolated
Tumor necrosis factor-alpha (TNFalpha) is a key pro-inflammatory cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, bowel disease, neurodegenerative disorders such as Alzheimer Disease. Effective inhibition TNFalpha essential for mitigating disease progression improving patient outcomes. In this study, we present development comprehensive characterization potent humanized inhibitory nanobodies (TNFI-Nbs) derived from...
Apart from life-threatening and/or functional emergencies, treatment of vascular lesions in giant cell arteritis (GCA) is medical. Revascularization may be considered if the lesion remains symptomatic or progressive despite optimal medical treatment, provided that there no disease-related inflammation, and always managed by a team trained experts. The main risk associated with aortic involvement (aortitis) development an aneurysm, most often thoracic aorta, after several years progression....
(1) Background: To determine which factors are associated with the volume of monosodium urate (MSU) crystal deposition quantified by dual-energy computed tomography (DECT) in urate-lowering therapy (ULT)-naive gout patients. (2) Methods: In this multicenter cross-sectional study, DECT scans knees and feet/ankles were prospectively obtained from ULT-naive Demographic, clinical (including history comorbidities), biological data collected, their association MSU was analyzed using bivariate...
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) through their capacity produce chemokines recruiting T and monocytes arterial wall ability migrate proliferate neointima where they acquire myofibroblast (MF) phenotype, leading vascular stenosis. This study aimed investigate if MFs could also impact T-cell polarization. Confocal microscopy was used analyze fresh fragments temporal artery biopsies (TABs). Healthy TAB sections...
Objectif: Elaborer des recommandations pour la prise en charge pratique courante malades atteints de pseudo polyarthrite rhizomélique (PPR). Méthodes: Suivant les procédures standardisées, une revue systématique littérature effectuée par 5 rhumatologues juniors supervisés, à partir questions retenues le comité pilotage (5 séniors) a servi base aux réunions travail puis réunion plénière sur journée avec groupe (15 membres), conduisant l'élaboration libellés et détermination force du degré...
Warm autoimmune hemolytic anemia (wAIHA) is a rare acquired disease mediated by antibodies targeting red blood cells. The involvement of CD4 T-helper cells has been scarcely explored, with most findings extrapolated from animal models. Here, we performed quantification both effector T lymphocytes (Teff) and regulatory (Treg), associated functional transcriptomic analyses Treg in human wAIHA. We observed shift Teff toward Th17 polarization concordant an increase serum interleukin-17...
A 48-year-old man with end-stage renal disease presented shortness of breath. Computed tomography the face revealed mandibular hypertrophy and a heterogeneous appearance bone, findings consistent osteitis fibrosa cystica.
Diagnosis of axial spondyloarthritis (axSpA) is nowadays commonly made with the help pelvic radiography or magnetic resonance imaging (MRI). However, there an important inter-observer variability in radiography, and MRI subject to possible false positives not best modality for studying structural lesions. Conversely, computed tomography (CT) has excellent specificity appears be more effective than diagnosis ankylosing spondylitis (AS). its findings patients over 50 years age have yet been...
In gout, several types of dual-energy computed tomography (DECT) artifacts have been described (nail bed, skin, beam hardening, submillimeter and vascular artifacts), which can lead to overdiagnosis. The objective this study was determine the optimal DECT settings for post processing in order reduce frequency some common patients with suspected gout.Seventy-seven hospitalized gout (feet/ankles and/or knees) who received a imaging were included (final diagnosis 43 34 other rheumatic...