Sophie Hecquet

ORCID: 0000-0002-9560-2594
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About
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Research Areas
  • Rheumatoid Arthritis Research and Therapies
  • Spondyloarthritis Studies and Treatments
  • Autoimmune and Inflammatory Disorders Research
  • Systemic Lupus Erythematosus Research
  • Cytokine Signaling Pathways and Interactions
  • Orthopedic Infections and Treatments
  • Bone and Joint Diseases
  • Infectious Diseases and Tuberculosis
  • Pharmacological Effects of Natural Compounds
  • Adolescent and Pediatric Healthcare
  • Psoriasis: Treatment and Pathogenesis
  • Inflammatory Bowel Disease
  • Ocular Diseases and Behçet’s Syndrome
  • Peripheral Neuropathies and Disorders
  • Inflammatory Myopathies and Dermatomyositis
  • Healthcare Systems and Practices
  • Spine and Intervertebral Disc Pathology
  • Drug-Induced Adverse Reactions
  • Chronic Lymphocytic Leukemia Research
  • Osteomyelitis and Bone Disorders Research
  • Urticaria and Related Conditions
  • Brain Tumor Detection and Classification
  • Pathogenesis and Treatment of Hiccups
  • SARS-CoV-2 detection and testing
  • Vasculitis and related conditions

Université Paris Cité
2023-2025

Hôpital Cochin
2023-2025

Assistance Publique – Hôpitaux de Paris
2023-2025

Institut Cochin
2024

Inserm
2024

Centre Hospitalier Universitaire de Besançon
2019-2023

Université de franche-comté
2023

Université Bourgogne Franche-Comté
2021-2022

Société Française de Rhumatologie
2020

Background: Patients with rheumatoid arthritis (RA) and other chronic inflammatory rheumatic disorders have increased risk of cardiovascular disease (CVD) venous thromboembolism (VTE) compared the general population. Moreover, recent data raised concerns around a possible major CV events (MACE) VTE in patients treated JAK inhibitors (JAKi). In October 2022, PRAC has recommended measures to minimize serious side effects, including conditions VTE, associated all approved diseases. Objective:...

10.1016/j.jbspin.2023.105592 article EN cc-by-nc-nd Joint Bone Spine 2023-05-17

Abstract Objectives To compare the features of difficult-to-treat rheumatoid arthritis (D2TRA) patients using two different definitions according to previous failure targeted therapies. Methods We stratified consecutive RA treated at Cochin Hospital into groups, a D2TRA group and non-D2TRA group, D2TRA. Both defined as RAs failing least therapies, with mechanism action for EULAR-D2TRA definition or without prejudging Alternative definition. Results included 320 patients. identified 76 244...

10.1093/rheumatology/kead143 article EN Lara D. Veeken 2023-03-24

The objective was to pinpoint specific circulating angiogenic and inflammatory markers of refractory active RA. We used Luminex technology measure the concentrations 17 RA-representative serum in 211 RA patients categorized into three groups: (failure 2 or more targeted therapies) (persistence signs disease activity) RA, non-refractory ≥ 1 csDMARDs a first line therapy) non-active (DAS28 ≤ 3.2). Refractory differed duration, structural damage utilization biologic therapy. failed distinguish...

10.1038/s41598-025-87318-8 article EN cc-by-nc-nd Scientific Reports 2025-02-28

Abstract Background Intestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear their contribution to pathogenesis of disease is still a matter debate. Objectives To study time-course inflammation (I-Inf), IP, microbiota modification BT rat model reactive arthritis, adjuvant-induced arthritis (AIA). Methods Analysis was performed 3 phases control AIA rats:...

10.1186/s13075-023-03069-9 article EN cc-by Arthritis Research & Therapy 2023-06-06

Objectif: Elaborer des recommandations pour la prise en charge pratique courante malades atteints de pseudo polyarthrite rhizomélique (PPR). Méthodes: Suivant les procédures standardisées, une revue systématique littérature effectuée par 5 rhumatologues juniors supervisés, à partir questions retenues le comité pilotage (5 séniors) a servi base aux réunions travail puis réunion plénière sur journée avec groupe (15 membres), conduisant l'élaboration libellés et détermination force du degré...

10.1016/j.rhum.2024.06.004 article FR cc-by Revue du Rhumatisme 2024-06-06

Actualisation des recommandations de la Société française rhumatologie (SFR) pour prise en charge pratique courante malades atteints spondyloarthrite, incluant le rhumatisme psoriasique. Suivant les procédures standardisées, une revue systématique littérature, effectuée par 4 rhumatologues juniors supervisés, à partir questions individualisées groupe travail (16 séniors), a servi base trois réunions travail, avec détermination force et du degré d'accord experts. Cinq principes généraux 15...

10.1016/j.rhum.2021.11.010 article FR cc-by-nc-nd Revue du Rhumatisme 2022-01-21

Lesions detected by magnetic resonance imaging (MRI) of the sacroiliac joints are critical to diagnosis non-radiographic axial spondyloarthritis. However, inflammatory and structural lesions may be encountered in other conditions.The objective this study was evaluate compare frequency localization on MRIs joint spondyloarthritis (SpA) non-spondyloarthritis (non-SpA) patients.This is a retrospective including 200 patients, each having undergone an MRI joints.Two experienced readers evaluated...

10.1177/1759720x221119245 article EN cc-by-nc Therapeutic Advances in Musculoskeletal Disease 2022-01-01

<h3>Background:</h3> The transition is a key moment in the management of patients with juvenile idiopathic arthritis (JIA). However, despite advances that have been made to facilitate this crucial period, too many are still being lost [1]. Patient education (PE) one tools help and caregivers during from paediatric adult rheumatology. <h3>Objectives:</h3> aim study was explore expectations adolescents JIA their caregivers, view developing PE workshop tailored needs when they arrive on...

10.1136/annrheumdis-2024-eular.4495 article EN Annals of the Rheumatic Diseases 2024-06-01

<h3>Background:</h3> Impaired hand function in SSc is a primary cause of disability and contributes to diminished health-related quality life. There still considerable amount work needed identify the main drivers such disturbances from skin, vascular or musculoskeletal (MSK) damages. A better understanding would guide management allow improve therapies. <h3>Objectives:</h3> To assess whether which clinical, ultrasonographic radiographic features MSK damages has an influence on impairment...

10.1136/annrheumdis-2024-eular.3061 article EN 2024-06-01
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