A5026197564- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Otitis Media and Relapsing Polychondritis
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- IgG4-Related and Inflammatory Diseases
- Innovations in Educational Methods
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders
- T-cell and B-cell Immunology
- Inflammatory Myopathies and Dermatomyositis
- Chronic Myeloid Leukemia Treatments
Maison des Sciences de l’Homme de Dijon
2014-2025
University of Florence
2006-2025
Clinical Trial Investigators
2025
CHU Dijon Bourgogne
2015-2024
Inserm
2015-2024
Université de Bourgogne
2012-2024
Université Bourgogne Franche-Comté
2015-2024
Weatherford College
2023
Unit of Virus Host Cell Interactions
2023
Thales (France)
2019-2023
From an immunologic standpoint, the mechanisms by which treatment with tocilizumab (TCZ), a humanized anti-interleukin-6 (anti-IL-6) receptor antibody, results in improvement rheumatoid arthritis (RA) patients are still not fully understood. In vitro studies and mouse models have demonstrated critical role of IL-6 Th17 cell differentiation. lymphocytes been shown to be strongly involved RA pathogenesis, purpose this study was investigate effect blockade on balance between cells Treg active...
To compare individually tailored, based on trimestrial biological parameter monitoring, to fixed-schedule rituximab reinfusion for remission maintenance of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs).Patients with newly diagnosed or relapsing granulomatosis polyangiitis (GPA) microscopic (MPA) in complete after induction therapy were included an open-label, multicentre, randomised controlled trial. All tailored-arm patients received a 500 mg infusion at...
To assess efficacy and safety of rituximab (RTX) as induction therapy, maintenance remission treatment relapses in a cohort IgG4-related disease (IgG4-RD) patients.Nationwide retrospective multicenter study IgG4-RD patients treated with at least one course RTX. Clinical, biological radiological response, relapse rate drug tolerance were analyzed. Kaplan-Meier curves plotted risk factors for studied Cox regression model.Among 156 included the French database, 33 received rituximab. Clinical...
Biannual rituximab infusions over 18 months effectively maintain remission after a "standard" induction regimen for patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).To evaluate the efficacy of prolonged therapy in preventing AAV relapses granulomatosis polyangiitis (GPA) or microscopic (MPA) who have achieved complete completing an 18-month maintenance regimen.Randomized controlled trial. (ClinicalTrials.gov: NCT02433522).39 clinical centers France.68 GPA and 29...
<h3>Background</h3> Giant cell arteritis (GCA) is the most common vasculitis in people ≥50 years and can be associated with stroke. We aimed to evaluate epidemiology characteristics of stroke patients GCA. <h3>Methods</h3> All a biopsy-proven diagnosis GCA were identified among residents city Dijon, France (152 000 inhabitants), between 2001 2012 using prospective database. Among these, who suffered from retrieved by crossing data population-based Dijon Stroke Registry. Demographics clinical...
Objective. Our aim was to describe patients with giant cell arteritis (GCA)–related stroke and compare them a control group of GCA without stroke. Methods. We created retrospective multicenter cohort (1) diagnosed according the American College Rheumatology criteria between 1995 2015, (2) occurring at time diagnosis or within 4 weeks starting therapy. The consisted Results. Forty [21 women (53%), median age 78 (60–91) yrs] GCA-related were included compared 200 patients. Stroke occurred in...
We examine and characterize subsets of circulating lymphocytes in untreated patients with active IgG4-related disease (IgG4-RD). Twenty eight consecutive proven IgG4-RD were included a prospective, multicentric study. Lymphocytes analyzed by flow cytometry, analysis TH1/TH2/TH17, TFH cells cytokine release peripheral blood mononuclear cells. Results compared healthy controls primary Sjogren syndrome. Patients characterized an increase T regulatory cells, TH2, TH17 the CD4+CXCR5+PD1+ subset....
Thrombotic manifestations are a hallmark of many auto-immune diseases (AID), specially warm autoimmune hemolytic anemia (wAIHA), as 15 to 33% adults with wAIHA experience venous thromboembolic events (VTE). However, beyond the presence positive antiphospholipid antibodies and splenectomy, risk factors for developing VTE during have not been clearly identified. The aim this retrospective study was characterize VTEs identify VTE. Forty-eight patients were included, among whom 26 (54%) had...
To describe the characteristics and outcome of patients with association large vessel vasculitis (LVV, Takayasu arteritis [TA] or giant cell [GCA]) inflammatory bowel disease (IBD). An observational, multicentre, retrospective case-control study. Cases were LVV-IBD from European countries, whereas controls had isolated LVV (iLVV). 39 TA-IBD 12 GCA-IBD cases enrolled, compared 52 GCA (iGCA) 93 TA (iTA) controls. occurred after IBD in 56% 75% GCA-IBD, a median interval 1 year (IQR 1-7) 8.6...
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Splenic macrophages play a key role in immune thrombocytopenia (ITP) pathogenesis by clearing opsonized platelets. Fcγ receptors (FcγR) participate this phenomenon, but their expression on splenic and modulation treatment have scarcely been studied human ITP. We aimed to compare the phenotype function of between six controls 24 ITP patients according treatments they received prior splenectomy. CD86, leucocyte antigen D-related (HLA-DR) FcγR were measured flow cytometry macrophages. The major...