A5028182117- Natural Antidiabetic Agents Studies
- Lymphoma Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Phytochemistry Medicinal Plant Applications
- Agricultural and Food Sciences
- Cancer Treatment and Pharmacology
- Medicinal Plant Extracts Effects
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- CNS Lymphoma Diagnosis and Treatment
- Botanical Research and Applications
- Coffee research and impacts
- Monoclonal and Polyclonal Antibodies Research
- Food composition and properties
- Ginkgo biloba and Cashew Applications
- Pharmacology and Obesity Treatment
- Coenzyme Q10 studies and effects
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Fungal Infections and Studies
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
Universidade José do Rosário Vellano
2019-2024
Union des Industries Ferroviaires Européennes
2019-2024
Universidade Federal de Alfenas
2015-2023
Universidad Femenina del Sagrado Corazón
2020-2021
Centre Hospitalier Universitaire de Besançon
2019
Institut Pasteur
2015
Centre National de la Recherche Scientifique
2015
Institut de Cancérologie de Lorraine
2013
Centre Antoine Lacassagne
2013
Centre Hospitalier de Saint-Brieuc
2013
Until recently, melphalan and prednisone were the standards of care in elderly patients with multiple myeloma. The addition thalidomide to this combination demonstrated a survival benefit for age 65 75 years. This randomized, placebo-controlled, phase III trial investigated efficacy plus older than years newly diagnosed myeloma.Between April 2002 December 2006, 232 previously untreated myeloma, or older, enrolled 229 randomly assigned treatment. All received (0.2 mg/kg/d) (2 12 courses (day...
PURPOSE To clarify disease characteristics and optimal treatment for elderly patients with non-Hodgkin's lymphoma (NHL), we performed a randomized trial in 453 older than 69 years aggressive lymphoma. PATIENTS AND METHODS Two hundred twenty received cyclophosphamide 750 mg/m2, teniposide (VM-26) 75 prednisone 40 mg/m2/d 5 days (CVP) 233 CVP plus pirarubicin (THP-doxorubicin) 50 mg/m2 (CTVP), each six courses every 3 weeks. RESULTS The median age was years. Most had clinically disease; 30%...
The utility of [(18)F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end induction therapy is well documented Hodgkin's and diffuse large B-cell lymphomas, but its role follicular lymphoma (FL) remains undetermined. We investigated prognostic significance PET-CT performed after first-line patients with FL treated prospective Primary Rituximab Maintenance (PRIMA) study.Results scans immunochemotherapy were recorded...
Cryptococcus neoformans is a human opportunistic fungal pathogen causing severe disseminated meningoencephalitis, mostly in patients with cellular immune defects. This species divided into three serotypes: A, D, and the AD hybrid. Our objectives were to compare population structures of serotype A D clinical isolates assess whether infections hybrids differ from other serotypes. For this purpose, we analyzed 483 corresponding data 234 enrolled during CryptoA/D study or nationwide survey on...
This study aimed to develop a chitosan-based hydrogel containing mixture of flavonoids isolated from the leaves Passiflora edulis Sims and evaluate its stability, antioxidant properties, wound healing effects on cutaneous lesions in diabetic rats. vitro studies were carried out biocompatibility flavonoid release chitosan hydrogel. vivo conducted male Wistar rats, where injured tissue was removed for histological analysis determination lipid peroxidation, superoxide dismutase activity,...
In this study, the effects of a green banana pasta diet on oxidative damage from type 1 diabetes mellitus (DM) were investigated.Formulations containing 25 (F25), 50 (F50), and 75% (F75) prepared included in 12-week Wistar rats with alloxan-induced DM. The these formulations preventing kidneys liver homogenates evaluated using TBARS assay (lipid peroxidation liver) DNPH (protein oxidation kidneys). Furthermore, fasting glycemia, fructosamine levels, renal function (creatinine), (enzymes...
BACKGROUND The current study was performed to determine the efficacy and safety of first‐line combination therapy with bevacizumab, paclitaxel, capecitabine for triple‐negative, locally advanced/metastatic breast cancer (LA/MBC). METHODS Patients measurable triple‐negative LA/MBC who had received no prior chemotherapy their disease 4‐weekly cycles paclitaxel (80 mg/m 2 on days 1, 8, 15 up 6 cycles) combined (800 twice daily 1‐5, 8‐12, 15‐19) bevacizumab (10 mg/kg 1 14) repeated every 4 weeks...
BACKGROUND With the introduction of new drugs such as interferon-α (IFN) and purine analogs, management hairy cell leukemia (HCL) patients has changed. However, pentostatin been found to produce higher complete remission rates than IFN. The current study was undertaken investigate response long term follow-up in HCL treated with pentostatin. METHODS Between March 1989 October 1996, 49 1 patient a variant were Eighteen had received no prior therapy, 31 treatment IFN, 2′-chlorodeoxyadenosine...
The oil obtained from baru (Dipteryx alata Vog.) almonds exhibits high energy value and is reported in popular medicine for the treatment of rheumatic diseases reproductive disturbances. Although used domestic cuisine, chemical characterization this its effects on lipid metabolism are still poorly understood. Therefore, study evaluated fatty acid (FA) profile liver aorta a murine model dyslipidemia. chromatographic showed levels unsaturated FAs, especially oleic acid. Saturated such as...
Some literature studies have shown the popular use of species Eugenia sp. leaves as an antioxidant, hypoglycemic, hypotensive and antipyretic. However, E. florida DC. shows few in this field knowledge. In way, it becomes a choice for further research. Several chemical compounds, such phenolic acids, flavonoids, saponins tannins, previously been identified may be related to biological activity. The aim present work was done identify compounds hydroethanolic extract by high-performance liquid...
The influence of bone marrow biopsy (BMB) histology on prognosis and management follicular lymphomas (FL) remains controversial. A total 390 patients with grade 1 or 2 FL were prospectively included in the multicentric Groupe d'Etude des Lymphomes Folliculaires trial their BMB reviewed order (i) to quantify ratio lymphomatous foci (LFo) area that size (LFo/BMB), (ii) determine patterns for a practical grading infiltration, (iii) assess intra- inter-observer reproducibility this (iv) analyse...
Background: This open controlled prospective study aimed at evaluating the medical and economical impact of first line chemotherapy for metastatic breast cancer (MBC). Patients Methods: Two groups HER +++ MBC patients were compared: 26 treated by a combination trastuzumab paclitaxel in 4 "prescriber" centers (group A) 19 any without addition trastuzumab, 6 control B). The cost related hospitalizations was taken into account during 8 cycles. Results: Forty-five patients, mean age 51 years...
Different Passiflora species have been appointed as a promising herbal medicine due to antioxidant properties; however, their effect on oxidative process induced by diabetes is still controversial. We aimed evaluate effects of hydroethanolic extract 70% from P. edulis leaf biochemical blood markers, collagen glycation, production oxidant and platelet aggregation in diabetic rats. The phytochemical analysis the was performed dereplication using LC coupled Photodiode Array Detector Mass...
Summary The treatment of low‐tumour burden follicular lymphoma ( LTBFL ) remains a challenge. Rituximab‐based strategies may be improved by adding chemotherapy. This Lymphoma Study Association multicentre phase II study assessed rituximab and bendamustine in 63 patients with untreated who were aged over 60 years old had International Prognostic Index FLIPI score ≥2. Induction comprised 4 weekly cycles 375 mg/m 2 intravenously combined 90 days 1–2 28‐day interval, followed twelve maintenance...
Abstract Objectives This study was carried out to evaluate the effects of flavonoids present in leaves Passiflora edulis fruit on complications induced by diabetes rats. Methods The extract P. leaf obtained 70% ethanol maceration. From dry extract, fractions were consecutive liquid–liquid partition with hexane, ethyl acetate and n-butanol. content isoorientin n-butanol determined ultra-performance liquid chromatography coupled electrospray triple quadrupole ionization (TQD) analysis tandem...
Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications diabetes mellitus. In this context, Myrtaceae family popularly used in Brazil treatment mellitus, including Eugenia sonderiana, shown beneficial effects due to presence phenolic compounds and saponins chemical constitution. Thus, present work aimed perform characterization hydroethanolic extract E. sonderiana leaves using...
The der(16)t(l;16)(qll;qll) is a frequent recurrent rearrangement in solid tumours such as breast carcinomas and Ewings sarcomas. Recently, this abnormality was described also multiple myeloma. We identified three patients with myelodysplastic syndrome, either during preleukaemic phase (n = 2) or at the time of blastic transformation 1). Breakpoints were ascertained by fluorescence situ hybridization (FISH) using specific centromeric a‐satellite probes whole chromosome painting for 1 16....
abstract This study was conducted to evaluate the effects of ethanolic extract Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity and macrophage phagocytic capacity after Candida albicans exposure in diabetic rats. The Sims were dried 40°C, powdered, extracted by maceration 70% ethanol, evaporated under reduced pressure lyophilised. biochemical tests performed total phenolic content (TP) as determined Folin-Ciocalteu assay, trapping potential DPPH assay...
Diabetes Mellitus (DM) ainda representa um sério problema de saúde pública, carente novas alternativas terapêuticas. Plantas estão entre as possíveis fontes novos compostos com ação anti-hiperglicêmica ou servindo como fitoterápicos. Neste estudo, avaliou-se o efeito anti-hiperglicêmico do extrato etanólico das folhas Raphanus sativus (nabo forrageiro) administrado por gavagem (dose oral 300 mg/kg/dia) em ratos Wistar DM tipo 1 induzido aloxana, durante 90 dias. A efetividade deste...
A complexidade da psoríase, a escassa correlação clínica com demais aspectos influentes e dificuldade dos tratamentos relacionados ela, dificulta melhora quadros clínicos de diversos indivíduos que sofrem doença. Por esse motivo, é extrema importância buscar compreender melhor seus mecanismos fatores externos envolventes na patologia, para um auxílio no tratamento. O objetivo pesquisa conhecer os imunológicos inflamação, bem como maneira podem influenciar causa ou agravamento psoríase...