É. Rouveix
A5036677523- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- Infective Endocarditis Diagnosis and Management
- HIV, Drug Use, Sexual Risk
- Healthcare Systems and Practices
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Pneumonia and Respiratory Infections
- Hepatitis C virus research
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Herpesvirus Infections and Treatments
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Pituitary Gland Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Fungal Infections and Studies
- Peripheral Neuropathies and Disorders
Hôpital Ambroise-Paré
2015-2024
Université Paris Cité
1997-2024
Assistance Publique – Hôpitaux de Paris
2009-2024
Université Paris-Saclay
2020-2024
Université de Versailles Saint-Quentin-en-Yvelines
2012-2023
Fondation Mérieux
2012-2022
Hôpital Raymond-Poincaré
2021-2022
CHU Ambroise Paré
1992-2021
Association pour l'Utilisation du Rein Artificiel dans la région Lyonnaise
2021
Hôpitaux Universitaires Paris-Ouest
2016-2017
Recent studies have suggested an increased risk of acute hepatitis C (HCV) infection in homosexual HIV-infected men and that early treatment with standard or pegylated interferon-alfa, alone associated ribavirin, significantly reduces the chronic evolution patients.A retrospective analysis 12 patients who were consecutively diagnosed as developing HCV infection, defined by both seroconversion anti-HCV antibodies detection serum RNA those previous negative results. Ten these received...
The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. research objectives focus mainly mid- and long-term clinical outcomes therapeutic strategies, as well severe AIDS non-AIDS morbidities, public health issues relative to infection. FHDH also serves describe HIV-infected patients receiving hospital care in France. includes data more than 120 000 from 70 general or university hospitals distributed throughout Patients are...
Cryptococcus neoformans is a human opportunistic fungal pathogen causing severe disseminated meningoencephalitis, mostly in patients with cellular immune defects. This species divided into three serotypes: A, D, and the AD hybrid. Our objectives were to compare population structures of serotype A D clinical isolates assess whether infections hybrids differ from other serotypes. For this purpose, we analyzed 483 corresponding data 234 enrolled during CryptoA/D study or nationwide survey on...
In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that from HIV-infected individuals on combined antiretroviral drug therapy (ART) low blood CD4+ T cell counts (<350 cells/μl) contained replication-competent despite viral suppression. vitro, harboring propagated the virus macrophages, a process could be prevented biologic abciximab, an anti-integrin αIIb/β3 Fab. Furthermore, our cohort, 88%...
Objective To assess the efficacy of highly active antiretroviral treatment (HAART) on AIDS–Kaposi's sarcoma (KS). Design Prospective cohort patients followed for 24 months. Setting Four referral hospitals West Paris metropolitan area. Patients/intervention Thirty-nine AIDS–KS patients, 42 ± 9 years old, who began HAART (HIV-protease inhibitor and two nucleoside analogues) between March December 1996, were enrolled. One was lost to follow-up at month 12. Main outcome measures KS response,...
A recent consensus defines "late presentation" (LP) during the course of HIV infection as presentation with AIDS whatever CD4 cell count or <350 cells per cubic millimeter. Here, using this new definition, we examined frequency and predictors LP its impact on mortality.In antiretroviral-naive patients enrolled in French Hospital Database between 2003 2009, studied risk factors for by multivariable logistic regression. The mortality was analyzed according to level immunodeficiency Cox models...
BackgroundThe start of the COVID-19 vaccination campaign among French healthcare and welfare sector workers in January 2021 offered an opportunity to study psychological antecedents this group.AimWe explored whether knowledge attitude items related social conformism confidence systems contributed explaining intention for vaccination.MethodsWe developed a questionnaire with 30 five established two hypothetical (KA-7C). The online was distributed from 18 December 2020 1 February through...
Background: The extent to which the prognosis for AIDS and death of patients initiating highly active antiretroviral therapy (HAART) continues be affected by their characteristics at time initiation (baseline) is unclear. Methods: We analyzed data on 20,379 treatment-naive HIV-1-infected adults who started HAART in 1 12 cohort studies Europe North America (61,798 person-years follow-up, 1844 events, 1005 deaths). Results: Although baseline CD4 cell count became less prognostic with time,...
We examined if the CNS Penetration-Effectiveness (CPE) score of antiretroviral drugs was associated with survival after a diagnosis HIV-related encephalopathy, progressive multifocal leukoencephalopathy (PML), cerebral toxoplasmosis, or cryptococcal meningitis.Using data from FHDH-ANRS CO4, we compared 9,932 HIV-infected patients diagnosed first neurologic AIDS-defining event in pre-combination therapy (cART) (1992-1995), early cART (1996-1998), late (1999-2004) periods. Follow-up subdivided...
IntroductionUnderstanding how hospital staff members (HSMs), including healthcare workers, acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first wave can guide control measures in current second Europe.MethodsFrom March 5 to May 10, 2020, Raymond-Poincaré Hospital held a weekday consultation for HSMs PCR testing. were requested complete questionnaire on their potential exposure SARS-CoV-2.ResultsOf 200 screened, 70 tested positive SARS-CoV-2. Ninety-nine...
Abstract Lipodystrophies, characterized by reduction of subcutaneous fat over part or all the body surface, are uncommon. Their causes unknown. Recently, lipodystrophy has been reported in human immunodeficiency virus (HIV)-infected patients taking protease inhibitors, which have recommended since 1996 as standard therapy for HIV disease combination with nucleoside analogues. In these cases, consists an association peripheral lipoatrophy central adiposity. We report four HIV-infected men on...
There is no known treatment for pulmonary cryptosporidiosis, a rare complication of intestinal cryptosporidiosis in AIDS patients. We report two cases which were unusual because (i) extracellular invasive forms the parasite found bronchoalveolar lavage and (ii) outcome was favorable one patient after with azithromycin.
Background Exposure to hepatitis B virus (HBV) remains a serious risk healthcare workers (HCWs) in endemic developing countries owing the strong prevalence of HBV general and hospital populations, high rate occupational blood exposure. Routine vaccination programs targeted high-risk groups especially HCWs are generally considered as key element prevention strategies. However, natural immunization among adults such where most infections occur perinatally or during early childhood must be...
To determine whether incident AIDS-defining Kaposi sarcoma or Pneumocystis jiroveci pneumonia (PJP) is associated with combination antiretroviral therapy (cART) initiation.
The benefits of continuing antiretroviral therapy are questionable in human immunodeficiency virus (HIV) type 1-infected patients with profound and multiple treatment failure due to viral resistance.From the French Hospital Database on HIV, we selected 12,765 a CD4(+) cell count <200 cells/mm(3) who received combination (cART) during 2000-2005. Three groups were defined: interrupted cART at least once, had 2 consecutive detectable loads (VLs) while receiving cART, undetectable VL cART....
Failure of treatment is the most serious complication in community-acquired pneumonia (CAP).To assess potential risk factors for failure clinically stable patients with CAP.This secondary analysis assesses data from a randomized clinical trial on CAP (Pneumonia Short Treatment [PTC] trial) conducted December 19, 2013, to February 1, 2018. Data was performed July 18, 2019, 15, 2020. Patients hospitalized at 1 16 centers France moderately severe who were day 3 antibiotic included PTC and...
Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful suppressing viral replication, cannot properly reconstitute patient circulating CD4 + T-cell number to immunocompetent levels. The causes for this immunological failure remain elusive, and no therapeutic strategy is available restore a proper immune response these individuals. We have recently demonstrated that platelets harboring...