A5079783600- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- Kawasaki Disease and Coronary Complications
- Hip and Femur Fractures
- Colorectal and Anal Carcinomas
- Malaria Research and Control
- Blood disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Erythrocyte Function and Pathophysiology
- Mosquito-borne diseases and control
- Bariatric Surgery and Outcomes
Inserm
2012-2023
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2014-2023
Sorbonne Université
2012-2023
Inserm Transfert
2014-2019
Santé Publique France
2019
Université Paris Cité
2009-2015
Groupe Hospitalier Diaconesses Croix Saint-Simon
2015
Centre Hospitalier Universitaire Henri-Mondor
2014
Hôpital Cochin
2014
Hôpital de la Conception
2014
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given difficulty of eradicating HIV-1, a functional for HIV-infected patients appears to be more reachable short-term goal. We identified 14 HIV (post-treatment controllers [PTCs]) whose viremia remained controlled several years after interruption prolonged cART initiated during primary Most PTCs lacked protective HLA B alleles that are overrepresented in spontaneous...
The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. research objectives focus mainly mid- and long-term clinical outcomes therapeutic strategies, as well severe AIDS non-AIDS morbidities, public health issues relative to infection. FHDH also serves describe HIV-infected patients receiving hospital care in France. includes data more than 120 000 from 70 general or university hospitals distributed throughout Patients are...
Abstract Background Many studies have reported weight gain in ART-naive people living with HIV (PWH) initiating an integrase strand-transfer inhibitor-based regimen. We studied the impact of early or advanced presentation and that individual drugs PWH combined ART (cART) between 2012 2018. Methods From French Hospital Database cohort, we assessed factors associated a ≥10%, change after cART initiation BMI increase ≥5 kg/m2 up to 30 months. The analyses were conducted overall, among (primary...
Although human immunodeficiency virus (HIV)-infected women are at high risk for anal cancer, few data have been published on prevalence of and factors precancer potential screening strategies in this group. A cross-sectional study was nested a gynecological cohort HIV-infected women. Anal swab specimens were collected cytology papillomavirus (HPV) testing. High-resolution anoscopy, with biopsy when indicated, systematically performed. Among the 171 enrolled women, median age 47.3 years 98%...
Objective: Our study investigated the rate of recurrence cervical intraepithelial neoplasia (CIN) in HIV-positive women after surgery era highly active antiretroviral therapy (HAART). Methods: One hundred twenty-one were followed-up with cytology, colposcopy, and histology for CIN. We conducted univariate multivariate analyses to determine relation between CIN risk factors using Cox proportional hazard models left truncation. Results: The any was 22.3 per 100 patient-years high-grade 8.6...
Background: The extent to which the prognosis for AIDS and death of patients initiating highly active antiretroviral therapy (HAART) continues be affected by their characteristics at time initiation (baseline) is unclear. Methods: We analyzed data on 20,379 treatment-naive HIV-1-infected adults who started HAART in 1 12 cohort studies Europe North America (61,798 person-years follow-up, 1844 events, 1005 deaths). Results: Although baseline CD4 cell count became less prognostic with time,...
The demonstration of in vitro cardiolipin reactivity with 2 human immunodeficiency virus (HIV)-specific, broadly neutralizing antibodies (2F5 and 4E10) has prompted reevaluation autoimmune manifestations HIV infection.We evaluated autoantibodies, particularly anticardiolipin (aCL), 67 untreated, asymptomatic, HIV-infected individuals slow progression disease their correlation 2F5-, 4E10-, b12-, 2G12-like directed against epitopes involved broad neutralization, as well immune activation...
Background. Little is known about the type-specific prevalence of anal human papillomavirus (HPV) infection and risk factors for high-risk (HR) HPV in immunodeficiency virus (HIV)–infected women. Methods. A cross-sectional study cervical was nested within a gynecological cohort HIV-infected Specimens were tested DNA using polymerase chain reaction–based assay. Results. The population consisted 311 women with median age 45.3 years, whom 42.8% originated from sub-Saharan Africa 96.8% receiving...
We performed a genome-wide association study comparing cohort of 144 human immunodeficiency virus (HIV type 1–infected, untreated white long-term nonprogressors (LTNPs) with 605 HIV-1–infected seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to III major histocompatibility complex (MHC) subregions, show statistical (false discovery rate, <0.05) the LTNP condition, among which 5 reached significance after Bonferonni correction. The MHC LTNP–associated...
Abstract Background Little is known on the use of artesunate compared with quinine for treatment imported malaria cases in nonendemic countries a high level care. Therefore, we 2 treatments terms mortality and hospital intensive care unit (ICU) discharge rates. Methods We analyzed cohort all severe patients reported to French National Reference Center from 2011 2017. After controlling differences between quinine- artesunate-treated individuals using inverse probability weighting method,...
Although highly active antiretroviral therapy (HAART) has lowered the incidence of various opportunistic diseases, its impact on cervical squamous intraepithelial lesions (SILs) is unclear. Our objective was to compare SILs in HIV-infected women receiving HAART versus those not and determine role risk factors including immunosuppression pathogenesis SIL.A total 298 with normal Papanicolaou (Pap) smear colposcopic findings at enrollment were followed-up until incident SIL or last follow-up...
Background It is unclear whether HIV infection affects the long-term prognosis after an acute coronary syndrome (ACS). The objective of current study was to compare rates major adverse cardiac and cerebrovascular events a first ACS between people living with (PLHIV) HIV-uninfected (HIV-) patients, identify determinants cardiovascular prognosis. Methods Results Consecutive PLHIV matched HIV- patients episode were enrolled in 23 intensive care units France. Patients for age, sex, type. primary...
Antibodies (Abs) play a central role in human immunodeficiency virus (HIV) protection due to their multiple functional inhibitory activities. W614A-3S Abs recognize specific form of highly conserved motif the gp41 envelope protein and can elicit viral neutralization protect CD4+ T cells. Here, we describe detail neutralizing profile untreated long-term non-progressor (LTNP) HIV-infected patients. were detected 23.5% (16/68) LTNP patients compared with <5% (5/104) HIV-1 progressor The had...
Abstract Switching antiretroviral therapy has been shown as safe and effective, but its impact on health-related quality of life (HRQL) was rarely measured. Our objective to assess changes in HRQL after switching an non-nucleoside reverse transcriptase inhibitors (NNRTI) containing regimen among NNRTI-naive HIV-infected patients with viral load (VL) <500 copies/mL. In this prospective observational study, the Hospital Anxiety Depression, Symptoms checklist, specific World Health Organization...
Introduction We compared biological outcomes in anti-retroviral-naive patients with viral load (VL) >5,000 copies/ml starting combivir-based, three-drug highly active antiretroviral therapy regimens 2001–2002 according to the third component, namely abacavir (ABC), nelfinavir (NFV), indinavir/ritonavir (IDV/r), lopinavir/ritonavir (LPV/r), nevirapine (NVP) or efavirenz (EFV). Methods evaluated virological response (HIV RNA <500 copies/ml) and immunological (increase of ≥50 CD4 +...
We studied trends in initial post infection CD4 cell counts and viral load values patients diagnosed at estimated time of primary between 1997 2005 France.We selected from the French Hospital Database on HIV white with documented dates sexually transmitted HIV-1 who had a first count (n = 1441) or assay 1402) within 12 months after before any antiretroviral therapy. Chronological were by using linear regression analysis.The declined an average 5.76 cells per cubic millimeter year [95%...
HIV-infected patients have lower bone mineral density and a higher incidence of fractures than the general population same age sex. To assess impact antiretroviral (ARV) drugs exposure on risk osteoporotic fractures, we conducted nested case-control study.Cases were individuals enrolled while ARV-naive, with first prospectively recorded fracture between 2000 2010. Controls randomly selected after matching for sex, (±3 years), period HIV diagnosis (<1997/≥1997), clinical center. The was...
The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) study has reported an increased risk cardiovascular diseases in people with human immunodeficiency virus who were exposed to darunavir (DRV) but not atazanavir (ATV). Our objective was evaluate associations between ATV or DRV exposures and the myocardial infarction (MI) a nested case-control within ANRS-CO4 French Hospital Database HIV (FHDH).Cases individuals had first validated MI 2006 2012. Up 5 controls selected at random...
Summary. Human parvovirus B19 (B19) has been transmitted by some brands of virally attenuated plasma‐derived factor VIII (FVIII) or IX (FIX) concentrates. To quantify the differences human risk transmission between albumin‐stabilized recombinant and factor, we studied prevalence IgG antibodies to (anti‐B19) in 193 haemophiliac children 1 6‐years age who had previously treated with FVIII only ( n = 104), solvent/detergent high‐purity non‐immunopurified non‐nanofiltered concentrates 89)....
ObjectivesTo compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or switched to PI-free cART including efavirenz, nevirapine abacavir.
Introduction We compared the effectiveness of tenofovir/emtricitabine (TDF/FTC) combined with either lopinavir/r (LPV/r) or another recommended third drug in 2010 French guidelines antiretroviral‐naïve patients starting combination antiretroviral therapy 2004–2008 Hospital Database on HIV. Methods The outcomes were stop switch component, viral load (VL) <500 copies/ml, an increase at least 100 CD4 cells/mm 3 , AIDS‐defining event and non‐AIDS‐defining hospitalization death. Propensity...
Abstract Background. In individuals with viral load (VL) suppression on a boosted protease inhibitor (PI) regimen, switch to raltegravir (RAL) can be an option in case of comorbidities, but the SWITCHMRK trials challenged this strategy. Here, among VL PI, we compared outcomes between those who continued same regimen and switched RAL. Methods. cohort study from French Hospital Database HIV, each individual RAL was matched up 3 were being followed during calendar period switch, had duration...