A5084674358- Air Quality and Health Impacts
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Smoking Behavior and Cessation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Childhood Cancer Survivors' Quality of Life
- Neuroscience and Neuropharmacology Research
- Indoor Air Quality and Microbial Exposure
- Cancer survivorship and care
- Sleep and Work-Related Fatigue
- HIV-related health complications and treatments
- Multiple and Secondary Primary Cancers
- Sleep and related disorders
- Forensic Toxicology and Drug Analysis
- Odor and Emission Control Technologies
- Palliative Care and End-of-Life Issues
- Advanced Glycation End Products research
- Health, Medicine and Society
- Sleep and Wakefulness Research
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Plant-based Medicinal Research
- Microbial metabolism and enzyme function
Biostatistique, traitement et modélisation des données biologiques
2019-2024
Université Paris Cité
2009-2024
Délégation Paris 5
2010-2022
Sorbonne Paris Cité
2012
Santé Publique France
2011
Sorbonne Université
2007-2010
Inserm
2003-2010
Hôpital Européen
2009
Assistance Publique – Hôpitaux de Paris
2009
Université de Tours
2007-2009
To study immunologic and clinical responses to HAART in patients over 50 years old.A prospective cohort which included 68 hospitals France. A total of 3015 antiretroviral-naive patients, 401 whom were aged or over, enrolled following initiation HAART. The influence age on the mean CD4 cell count increase was studied by using a two-slope mixed model. Progression, defined occurrence new AIDS-defining event (ADE) death, Cox multivariate analyses.Among with baseline HIV RNA above 5 log...
The aim of this study was to examine the effects supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected an unpredictable chronic mild (UCMS) procedure. Stress-induced modifications coat and aggressiveness were evaluated, phospholipid PUFA profiles monoamine levels analyzed frontal cortex, hippocampus, striatum. results showed that repeated exposure stressors induced degradation physical state coat, lowered body weight gain, increased...
The electronic cigarette (EC) has become popular among smokers who wish to reduce their tobacco use levels or quit smoking, but its effectiveness as a cessation aid is uncertain.To examine the association of regular EC with number cigarettes smoked per day, smoking current smokers, and relapse former smokers.The CONSTANCES (Consultants des Centres d'Examens de Santé) cohort study, based in France, began recruiting participants January 6, 2012, currently ongoing. Participants were enrolled...
ABSTRACT There is no reliable and simple diagnostic marker available to diagnose recent hepatitis C virus (HCV) infection. It has been shown that the avidity of specific IgG antibody low in primary viral infection increases with time. We report development an anti-HCV assay derived from a commercially test. A panel 117 sera was first examined for avidity. composed samples patients (group 1, n = 14), chronic 2, 70), resolved 3, 33) HCV infections. Avidity index (AI) values observed recently...
Certain chemical pollutants can exacerbate lower respiratory tract infections (LRIs), a common childhood ailment. Although formaldehyde (FA) is one of the most air found in indoor environments, its impact on infant health uncertain.Our aim was to determine FA exposure LRI incidence during first year life infants from Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort.FA measured random sample 196 infants' dwellings, this pollutant estimated for 2,940 using predictive models...
This study assessed sustainable return to work (SRTW) of breast cancer survivors (BCS).We used data from the prospective French cohort, CANTO. We included 1811 stage I-III BCS who were <57 years old and employed at moment diagnosis working 2 after diagnosis. Using logistic regression, we investigated role clinical, health socio-economic factors, environment on SRTW 3 compared having any sick leave with worked continuously being unemployed between diagnosis.Overall, 77% (n = 1395) (RTW). Out...
The benefits of continuing antiretroviral therapy are questionable in human immunodeficiency virus (HIV) type 1-infected patients with profound and multiple treatment failure due to viral resistance.From the French Hospital Database on HIV, we selected 12,765 a CD4(+) cell count <200 cells/mm(3) who received combination (cART) during 2000-2005. Three groups were defined: interrupted cART at least once, had 2 consecutive detectable loads (VLs) while receiving cART, undetectable VL cART....
Background Diabetes mellitus (DM) is a major and increasing public health problem that may be underdiagnosed undertreated among persons living with HIV (PLWH). Objective To describe the diagnosis, treatment follow-up of DM PLWH. Methods This study was performed inside monocentric cohort 1494 defined as having FG ≥126 mg/dL twice or HbA1c ≥6.5%, history diabetes, receiving antidiabetic treatment. The first visit mentioning diagnosis considered baseline visit. Chi-Square Fisher exact test were...
Objective To study the influence of level virologic rebound during combination antiretroviral therapy on time course CD4 count. Methods Between January 1997 and December 1999, we enrolled 3736 patients from French Hospital HIV Database who had an undetectable viral load a first highly active (HAART). Four levels were defined basis values year following initial undetectability HAART: group 1, all loads <500 copies/mL; 2, <5000 3, <10,000 4, at least 1 >10,000 copies/mL. We developed...
Cette etude avait pour objectif d’etudier les raisons des difficultes par hematologues francais a annoncer une mauvaise nouvelle un patient atteint d’hemopathie maligne. Un questionnaire comprenant trois parties ete envoye aux 917 membres de la Societe francaise d’hematologie (SFH) courrier electronique. La premiere partie incluait renseignements socio-demographiques. deuxieme comprenait 14 items evaluant le niveau et ces : etait-ce lie peur provoquer reactions chez patients ou se mettre en...
Abstract Introduction The knowledge of dabigatran levels is helpful for decision‐making in specific situations such as urgent surgery or when the question reversal arises (uncontrolled bleeding, eligibility thrombolysis). However, a limited number observational studies are available regarding comparisons between quantification methods. objective study was to compare plasma using three assays including reference method (high‐performance liquid chromatography coupled with mass spectrometry),...
HIV-specific cytotoxic CD8(+) T-lymphocytes (CTL) appear to be the cornerstone of immune response HIV infection. Recent studies show that CTL activity reflects patients' anti-HIV status and slows disease progression. However, dynamics diversity this also appears as a key parameter for control but is largely undocumented. We modelled changes in responses against seven principal proteins over time. studied influence plasma viral load on temporal protein recognition by memory CTL. The generic...
Background: Concerns have been raised about a possible excess risk of lymphomas in HIV-infected patients exposed to interleukin 2 (IL-2) therapy. Here we compared the risks non-Hodgkin lymphoma (NHL) and Hodgkin (HL) IL-2-treated IL-2-untreated patients. Methods: Patients monitored through French Hospital Database on HIV between May 1, 1995, December 31, 2005, were enrolled this study. Lymphomas that occurred day after study entry end follow-up eligible for analysis. Poisson regression...
<b><i>Background:</i></b> Cancer and aging are both frequently associated with malnutrition, a factor of poor prognosis. In adult cancer patients, this may be related in part to impaired energy metabolism, higher than predicted resting expenditure (REE) about 50% patients. We hypothesized that metabolism elderly patients could potentiate cancer-associated hypermetabolism, further promoting risk malnutrition. <b><i>Objective:</i></b> To study...
BackgroundPooled analysis of the TORO comparative clinical trial data sets showed a significantly higher incidence rate (IR) bacterial pneumonia (BP) among patients treated with enfuvirtide-containing combination antiretroviral therapy (ENF-cART) than in those other cART regimens.
ObjectivesWe investigated why, despite its beneficial effect on the CD4 cell count, IL-2 therapy had no clinical benefit as shown in ESPRIT and SILCAAT trials. We focused subgroups of patients defined according to counts at baseline over time assess threshold above which was longer a large cohort HIV-1 infected patients.
Medical cannabis, legalized in many countries, remains illegal France. Despite an experiment the medical use of cannabis that began March 2021 France, little is known about factors associated with for self-medication among adults.
Background Sleep disturbances (SDs) in childhood can negatively impact behavioral and emotional control, which lead to an increase risky behaviors, such as substance use, including alcohol.
Objective This study examined the longitudinal association between child sleep disturbances from ages 3 to 16 and smoking in adulthood among subjects a French cohort study.Methods Data 2,134 who participated TEMPO 1991 2018 were used. Sleep observed years defined our exposure. Tobacco consumption trajectories constitute outcomes ascertained by using Group-Based Trajectory Modeling, semiparametric probabilistic method that hypothesizes existence of distinct developmental over time within one...