A5041251664- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Adipose Tissue and Metabolism
- Organ Transplantation Techniques and Outcomes
- Amino Acid Enzymes and Metabolism
- Polyamine Metabolism and Applications
- Pancreatic function and diabetes
- Electrolyte and hormonal disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Cannabis and Cannabinoid Research
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Metabolomics and Mass Spectrometry Studies
- Muscle Physiology and Disorders
- Biochemical effects in animals
- Enhanced Recovery After Surgery
- Childhood Cancer Survivors' Quality of Life
- Fatty Acid Research and Health
Université Paris Cité
2013-2022
Assistance Publique – Hôpitaux de Paris
2013-2022
Hôpital Cochin
2013-2022
Observatoire de Paris
2021-2022
Inserm
2003-2022
Toxicologie, Pharmacologie et Signalisation Cellulaire
2022
Délégation Paris 5
2011-2021
Sorbonne Paris Cité
2013-2019
Sorbonne Université
1989-2017
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2016
Neuroendocrine and immune stresses imposed by chronic sleep restriction are known to be involved in the harmful cardiovascular effects associated with poor sleep.Despite a well-known beneficial effect of napping on alertness, its neuroendocrine stress responses after largely unknown.This study was strictly controlled (sleep-wake status, light environment, caloric intake), crossover, randomized design continuously polysomnography-monitored subjects.The conducted laboratory-based study.The...
Abstract A Western diet induces insulin resistance, liver steatosis (non-alcoholic fatty disease (NAFLD)) and intestinal dysbiosis, leading to increased gut permeability bacterial translocation, thus contributing the progression of NAFLD non-alcoholic steatohepatitis. In present study, we sought, in a model diet-induced NAFLD, determine whether citrulline (Cit), an amino acid that regulates protein energy metabolism, could decrease injuries, as well mechanisms involved. Sprague–Dawley rats...
Objective To compare the effectiveness on wound healing time in severe burn patients of ornithine α-ketoglutarate supplementation enteral feeding vs. an isonitrogenous control. Previous clinical and experimental studies suggest a beneficial effect enterally administered protein metabolism patients, but few data deal with outcome. Design Prospective double-blind randomized trial. Setting Burn treatment center army hospital. Patients Forty-seven total burned body surface areas 25% to 95%...
Enhancement of depressed plasma concentrations glutamine and arginine is associated with better clinical outcome. Supplementation might be a way to provide the patient glutamine, also arginine, because provides kidney citrulline, from which produces when levels are low. The aim present study was investigate parenteral enteral response administered dipeptide Ala-Gln, citrulline arginine. Therefore, seven patients received 20 g over 4 h, parenterally or enterally, on two separate occasions....
Abstract Excessive glucose production by the liver is a key factor in hyperglycemia observed type 2 diabetes mellitus (T2DM). Here, we highlight novel role of kinase B1 (Lkb1) this regulation. We show that mice with hepatocyte-specific deletion Lkb1 have higher levels hepatic amino acid catabolism, driving gluconeogenesis. This effect during both fasting and postprandial period, identifying as critical suppressor Hepatic associated major changes whole-body metabolism, leading to lower lean...
In type 2 diabetes (T2D) macrophage dysfunction increases susceptibility to infection and mortality. This may result from the associated decreased plasma concentration of arginine, an amino acid that plays important role in immunity. vitro , increasing arginine availability leads improvement function; however, supplementation diabetic obese patients be detrimental. The aim present study was assess whether citrulline, precursor, could replace regulation function under a condition obesity....
Dietary arginine (Arg) supplementation has been proposed to have positive effects on the development of liver diseases. In present study, we investigate if an oral Arg in diet protects mice fed a fructose, fat and cholesterol enriched Western-style (WSD) from non-alcoholic steatohepatitis (NASH). Female C57BL/6J were liquid control or WSD ± (2.49 g/kg body weight/day) for 6 weeks. Indices injury, glucose metabolism intestinal permeability determined. While had no weight gain, fasting blood...
Abstract Background: Measurement of keto-acids is important in various clinical situations. The aim the present work was to develop a rapid HPLC method for determination human serum and assess concentrations these acids young adults institutionalized elderly adults. This applied blood keto-acid people, divided into age groups Methods: Four (α-ketoisocaproate, α-ketoisovalerate, α-keto-β-methylvalerate, pyruvate) were derivatized with o-phenylenediamine give fluorescent derivatives. After...
Scope During aging, increased visceral adipose tissue (AT) mass may result in impaired metabolic status. A citrulline (CIT)‐supplemented diet reduces AT old rats. We hypothesized that CIT could directly affect fatty acid (FA) metabolism retroperitoneal AT. Methods and results 24‐h exposure of explants from (25 months) rats to 2.5 mM induced a 50% rise glycerol FA release, which was not observed young (2 animals. The phosphorylated form hormone‐sensitive lipase, key lipolytic enzyme, 1.5‐fold...
Owing to preferential electrostatic adsorption of multivalent cations on highly anionic surfaces, natural polyamines and especially quadrivalent spermine can be considered as potential regulators the complex dynamical properties MTs (microtubules). Indeed, C-terminal tails tubulin display many negative residues in a row which should enable formation correlated liquid-like phase counterions its surface. Although it is known that polyamine promote MT assembly vitro, little about relevance this...