A5033583070- Muscle Physiology and Disorders
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Glycogen Storage Diseases and Myoclonus
- Metabolism, Diabetes, and Cancer
- Transcranial Magnetic Stimulation Studies
- Pancreatic function and diabetes
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Nuclear Structure and Function
- Genetic factors in colorectal cancer
- Extraction and Separation Processes
- Erythrocyte Function and Pathophysiology
- Digestive system and related health
- Muscle metabolism and nutrition
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiomyopathy and Myosin Studies
- Stroke Rehabilitation and Recovery
- Cardiac electrophysiology and arrhythmias
- Minerals Flotation and Separation Techniques
- Electromagnetic Fields and Biological Effects
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Bauxite Residue and Utilization
Inserm
2015-2024
Sorbonne Université
2019-2024
Centre de Recherche en Myologie
2017-2024
Pitié-Salpêtrière Hospital
2024
Institut de Myologie
2023-2024
Université Paris Cité
2015-2021
Centre National de la Recherche Scientifique
2015-2021
Institut Cochin
2015-2021
Inova Design Solutions (United Kingdom)
2018
Physiologie de la Reproduction et des Comportements
2018
Biomimetic patterns of weak magnetic pulses modify gene expression and need cryptochrome to induce cerebellar reinnervation.
Abstract Excessive glucose production by the liver is a key factor in hyperglycemia observed type 2 diabetes mellitus (T2DM). Here, we highlight novel role of kinase B1 (Lkb1) this regulation. We show that mice with hepatocyte-specific deletion Lkb1 have higher levels hepatic amino acid catabolism, driving gluconeogenesis. This effect during both fasting and postprandial period, identifying as critical suppressor Hepatic associated major changes whole-body metabolism, leading to lower lean...
CaVβ1E boosts downstream growth differentiation factor 5 signaling to counteract muscle mass loss in denervated or aged mouse muscles.
Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β-catenin (CTNNB1-mutated HCC), constitute a very homogeneous group. We previously characterized distinctive metabolic histological phenotype for CTNNB1-mutated HCC. They were found well-differentiated, almost never steatotic, often cholestatic, microtrabecular or acinar growth pattern. Here, we investigated...
Background LKB1 is an evolutionary conserved kinase implicated in a wide range of cellular functions including inhibition cell proliferation, regulation polarity and metabolism. When Lkb1 inactivated the liver, glucose homeostasis perturbed, affected cholestasis develops. Cholestasis occurs as result from deficient bile duct development, yet how impacts on biliary morphogenesis unknown. Methodology/Principal Findings We characterized phenotype mice which deletion gene has been specifically...
Abstract Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during ageing, which results in increased inability death; however, no cure has been established thus far. Growth differentiation factor 5 (GDF5) described to modulate maintenance various contexts. For our proof concept, we overexpressed GDF5 by AAV vector injection tibialis anterior adult aged (20 months) mice performed molecular functional analysis muscle. We analysed human vastus lateralis biopsies...
Sarcopenia is a complex age-related muscular disease affecting 10 to 16 % of people over 65 years old. It characterized by excessive loss muscle mass and strength. Despite plethora studies aimed at understanding the physiological mechanisms underlying this pathology, pathophysiology sarcopenia remains poorly understood. To date, there no pharmacological treatment for disease. In context, our team develop therapeutic approaches based on GDF5 protein counteract function in various pathological...
Abstract Magnetic brain stimulation is a promising treatment in neurology and psychiatry, but clinical outcomes are variable. Unfortunately, mechanisms underlying magnetic effects ill-defined, which impedes the development of protocols appropriate for different neurological conditions. Here we show, vivo ex , that repetitive transcranial at low-intensity (LI-rTMS) induces axon outgrowth synaptogenesis to repair neural circuit. This depends on pattern, with complex patterns being particularly...
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22104-4