A5057938344- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Nerve injury and regeneration
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Ophthalmology and Eye Disorders
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- RNA regulation and disease
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Electromagnetic Fields and Biological Effects
- Mitochondrial Function and Pathology
- Hearing, Cochlea, Tinnitus, Genetics
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Cholesterol and Lipid Metabolism
- Circadian rhythm and melatonin
- Growth Hormone and Insulin-like Growth Factors
Sorbonne Université
2013-2023
Centre National de la Recherche Scientifique
2013-2023
Adaptation Biologique et Vieillissement
2014-2023
Institut de Biologie Paris-Seine
2014-2023
Sorbonne Paris Cité
2023
Hôpital Charles-Foix
2018-2022
Assistance Publique – Hôpitaux de Paris
2018-2019
The University of Western Australia
2005-2015
Université Paris Cité
2013-2014
Western University
2012
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field focused on target region during rTMS, adjacent areas also receive at lower intensity contribution of this perifocal to network-wide effects poorly defined. Here, we examined low-intensity rTMS (LI-rTMS)-induced changes model neural network using visual systems normal (C57Bl/6J wild-type, n = 22) ephrin-A2A5(-/-) (n mice, latter...
Although the organization of neuronal circuitry is shaped by activity patterns, capacity to modify and/or optimize structure and function whole projection pathways using external stimuli poorly defined. We investigate whether induced pulsed magnetic fields (PMFs) alters brain function. delivered low-intensity PMFs posterior cranium awake, unrestrained mice (wild-type ephrin-A2A5 -/-) that have disorganized retinocollicular associated visuomotor deficits. Control groups each genotype received...
Exposure to man-made electromagnetic fields (EMFs), which increasingly pollute our environment, have consequences for human health about there is continuing ignorance and debate. Whereas considerable ongoing concern their harmful effects, magnetic are at the same time being applied as therapeutic tools in regenerative medicine, oncology, orthopedics, neurology. This paradox cannot be resolved until cellular mechanisms underlying such effects identified. Here, we show by biochemical imaging...
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors restricted interests. Although genomic functional studies are beginning to reveal some of the genetic complexity underlying pathobiology ASD, consistently reported male bias ASD remains an enigma. We have recently proposed that retinoic acid-related orphan receptor alpha (RORA), which...
Neuronal maturation during development is a multistep process regulated by transcription factors. The factor RORα (retinoic acid-related orphan receptor α) necessary for early Purkinje cell (PC) but also expressed throughout adulthood. To identify the role of in mature PCs, we used Cre-lox mouse genetic tools vivo that delete it specifically from PCs between postnatal days 10–21. Up to 14 d age, differences mutant and control were not detectable: both mono-innervated climbing fibers (CFs)...
Biomimetic patterns of weak magnetic pulses modify gene expression and need cryptochrome to induce cerebellar reinnervation.
Background: Very weak transcranial magnetic stimulation (TMS, 10 mT, ~0.05-10 V/m) has been explored in animal models showcasing potential for effective neuromodulation. However, the physiological effects of these type pulsed fields remain rather unexplored humans. Objective: We here aimed to characterize neural very TMS ( ~6V/m, ~6% resting motor threshold, rMT) and explore their ability evoke and/or modulate local oscillatory activity generated on human primary regions. Methods:...
Topographically ordered projections are established by molecular guidance cues and refined neuronal activity. Retinal input to a primary visual center, the superior colliculus (SC), is bilateral with dense contralateral projection sparse ipsilateral one. Both topographically organized, but in opposing anterior–posterior orientations. This arrangement provides functionally coherent each from binocular field, supporting function. When involved topography (ephrin-As) absent, crossed retinal...
While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control excitability within injured brain order to induce repair. However, possible non-invasively modulate using stimulation techniques such as repetitive transcranial (rTMS) direct current (tDCS) techniques, which show promise for repairing circuits...
Non-invasive electromagnetic field brain stimulation (NIBS) appears to benefit human neurological and psychiatric conditions, although the optimal parameters underlying mechanisms remain unclear. Although in vitro studies have begun elucidate cellular mechanisms, is delivered by a range of coils (from commercially available laboratory-built circuits) so that fields induced within tissue produce reported effects are ill-defined. Here we develop simple device with plug-and-play features allow...
PEMF (Pulsed Electromagnetic Field) stimulation has been used for therapeutic purposes over 50 years including in the treatment of memory loss, depression, alleviation pain, bone and wound healing, certain cancers. However, underlying cellular mechanisms mediating these effects have remained poorly understood. In particular, because magnetic field pulses will induce electric currents stimulated tissue, it is unclear whether observed are due to or component stimulation. Recently, shown that...
Recovery of complex neural function after injury to the adult CNS is limited by minimal spontaneous axonal regeneration and/or sprouting from remaining pathways. In contrast, developing displays reorganization following lesion, in which uninjured axons can develop new projections appropriate target neurons and provide partial recovery behaviours. Similar pathways be induced mature CNS, providing models optimize post-injury functions. After unilateral transection a olivocerebellar path...
Magnetic brain stimulation is a promising treatment for neurological and psychiatric disorders. However, better understanding of its effects at the individual neuron level essential to improve clinical application. We combined focal low-intensity repetitive transcranial magnetic (LI-rTMS) rat somatosensory cortex with intracellular recordings subjacent pyramidal neurons in vivo. Continuous 10 Hz LI-rTMS reliably evoked firing ∼4-5 during period induced durable attenuation synaptic activity...
Errors of cerebellar development are increasingly acknowledged as risk factors for neuro-developmental disorders (NDDs), such attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), and schizophrenia. Evidence has been assembled from abnormalities in autistic patients, well a range genetic mutations identified human patients that affect the circuit, particularly Purkinje cells, associated with deficits motor function, learning social behavior; traits commonly However, NDDs,...
Abstract Correct neural function depends on precisely organized connectivity, which is refined from broader projections through synaptic/collateral elimination. In the rat, olivocerebellar topography by regression of multiple climbing fiber (CF) innervation Purkinje cells (PC) during first two postnatal weeks. The molecules that initiate this are not fully understood. We assessed role cerebellar neurotrophins examining tropomycin receptor kinase (Trk) expression in inferior olive and...
of 24h.In mammals, the suprachiasmatic nuclei hypothalamus coordinate circadian rhythms via peripheral molecular clocks composed at least fifteen genes that are expressed in every cell.Expression these clock gene is regulated by transcription factors organized positive (BMAL1 and CLOCK) or negative (PER CRY) feedback loops.Briefly, www.aging-us.com
A major problem of ageing is progressive impairment neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related degeneration. To test this, we examined Purkinje numbers, plasma cerebellar neurosteroid concentrations during normal (wild-type mice, WT), in our model precocious (Rora(+/sg), heterozygous staggerer mice which expression the neuroprotective factor RORα disrupted) after long-term hormone insufficiency (WT...