A5051720660- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Advanced Memory and Neural Computing
- Parkinson's Disease Mechanisms and Treatments
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Electromagnetic Fields and Biological Effects
- Nerve injury and regeneration
University College London
2021-2023
Sorbonne Université
2018-2023
Institut de Biologie Paris-Seine
2019-2022
Adaptation Biologique et Vieillissement
2017-2022
Centre National de la Recherche Scientifique
2018
Biomimetic patterns of weak magnetic pulses modify gene expression and need cryptochrome to induce cerebellar reinnervation.
Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to synapse dysfunction and AD. Consistently, a variant of LRP6 receptor, (LRP6-Val), reduced signaling, is linked late-onset However, impact LRP6-Val on healthy AD brain has not been examined. Knock-in mice, generated by gene editing, carrying this Lrp6 develop normally. neurons from Lrp6-val mice do respond Wnt7a,...
Synapse degeneration in the striatum has been associated with early stages of Parkinson’s and Huntington’s diseases (PD HD). However, molecular mechanisms that trigger synaptic dysfunction loss are not fully understood. Increasing evidence suggests deficiency Wnt signaling triggers synapse adult brain this pathway is affected neurodegenerative diseases. Here, we demonstrate endogenous essential for integrity a subset inhibitory synapses on striatal medium spiny neurons (MSNs). We found...
Symposium title: Mechanisms underlying magnetic stimulation: the need for animal studies description: Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique, which shows promise treating range of neuropsychiatric disorders. However, to improve clinical treatment, we answer questions about how TMS interacts with and identify its mechanisms. Such fundamental are effectively not possible in humans thus require experiments different species gain insights into...
Abstract Magnetic brain stimulation is a promising treatment in neurology and psychiatry, but clinical outcomes are variable. Unfortunately, mechanisms underlying magnetic effects ill-defined, which impedes the development of protocols appropriate for different neurological conditions. Here we show, vivo ex , that repetitive transcranial at low-intensity (LI-rTMS) induces axon outgrowth synaptogenesis to repair neural circuit. This depends on pattern, with complex patterns being particularly...
Abstract Synapse loss strongly correlates with cognitive decline in Alzheimer’s Disease (AD), but the underlying mechanisms are poorly understood. Studies suggest that deficient Wnt signalling, a pathway required for neuronal connectivity, contributes to synapse dysfunction and AD. Consistent this idea, variant of Lrp6, (Lrp6-val) , which confers reduced has been linked late onset However, impact Lrp6-val on synapses healthy AD brain not examined. Using CRISPR/Cas9 genome editing, we...