A5081703568- Malaria Research and Control
- Cancer Immunotherapy and Biomarkers
- Heart Rate Variability and Autonomic Control
- CAR-T cell therapy research
- Mosquito-borne diseases and control
- Cardiovascular Disease and Adiposity
- Immunotherapy and Immune Responses
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Sleep and Wakefulness Research
- Viral Infections and Outbreaks Research
- Complement system in diseases
- EEG and Brain-Computer Interfaces
- Spaceflight effects on biology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- Blood Coagulation and Thrombosis Mechanisms
- RNA Interference and Gene Delivery
- Global Maternal and Child Health
- Advanced biosensing and bioanalysis techniques
- Liver Disease and Transplantation
- Moringa oleifera research and applications
Sorbonne Université
2015-2023
Université Sorbonne Nouvelle
2023
Unité de Technologies Chimiques et Biologiques pour la Santé
2022
Inserm
2012-2022
Institut Gustave Roussy
2021-2022
Institut de Recherche pour le Développement
2018-2021
Université Paris Cité
2015-2021
Mère et Enfant en Milieu Tropical
2018-2021
Sorbonne Paris Cité
2015-2018
Assistance Publique – Hôpitaux de Paris
2016
Despite the clinically proven advantages of intermittent preventive treatment malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), utilisation has been low many African countries. To increase uptake and achieve desired effect, World Health Organization revised policy to a monthly administration. Assessing coverage impact on neonatal outcomes is, therefore, necessity. A 2-parallel cross-sectional hospital-based study was carried out among pregnant women attending first antenatal...
Abstract Background We aimed to determine the safety and efficacy of nintedanib, an oral anti-angiogenic tyrosine kinase inhibitor, in combination with pembrolizumab, anti-PD1 immunotherapy, patients advanced solid tumors (PEMBIB trial; NCT02856425). Methods In this monocentric phase Ib dose escalation cohort, we evaluated escalating doses nintedanib (Dose level 1 (DL1) = 150 mg bid [ bis die , as twice a day]; DL2 200 bid, delivery) pembrolizumab (200 Q3W, IV). Patients received 1-week...
Abstract Background Pregnant women are more susceptible to Plasmodium falciparum than before pregnancy, and infection has consequences for both mother offspring. The World Health Organization recommends that pregnant woman in areas of transmission receive intermittent preventive treatment (IPTp) starting the second trimester. Consequently, not protected during first trimester, although P. infections frequent harmful. Methods A cohort nulligravid was followed up subsequent pregnancy. Malaria...
We assess the contribution of common and rare putatively functional genetic variants (most them coding) present on Illumina exome Beadchip to variability plasma lipids stiffness carotid artery.Measurements were obtained from 2283 men 1398 women, after filtering exclusion monomorphic variants, 32,827 (minor allele frequency >0.01) 68,770 analyzed. A large fraction heritability is attributable array, especially for triglycerides (fraction variance measured genotypes: V(G)/V(p)=31.4%,...
The mechanisms that link metabolic syndrome (MetS) to increased cardiovascular risk are incompletely understood. We examined whether MetS is associated with the neural baroreflex pathway (NBP) and any such associations independent of blood pressure values. This study involved cross-sectional analysis data on 2835 subjects aged 50 75 years from Paris Prospective Study 3. prevalence was defined according American Heart Association/National Blood Lung Institute definition. NBP values were...
Sequestration of Plasmodium falciparum -infected erythrocytes expressing the VAR2CSA antigen in placenta results poor pregnancy outcomes, including low birth weight and maternal anemia. Antigen-specific antibody-mediated immunity is acquired during successive pregnancies. Thus, evaluating VAR2CSA-specific IgG profiles among pregnant women will increase knowledge on immunological mechanisms associated with protection, help development VAR2CSA-based placental malaria vaccines. Using PAMVAC...
Background Intratumoral (IT) administration of Ipilimumab (Ipi), could maximize its dose/efficacy ratio while preventing on-target/off-tumor systemic adverse events. We report the results a randomized multicenter Phase 1b study comparing IT vs IV Ipi with intravenous nivolumab (nivo) in patients metastatic melanoma. Methods Previously untreated melanoma were randomly assigned 1:2, to receive Nivo (1mg/kg) combination either (3mg/kg) or 10x lower dose (0.3mg/kg) Q3W for 4 doses, followed by...
Symposium title: Mechanisms underlying magnetic stimulation: the need for animal studies description: Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique, which shows promise treating range of neuropsychiatric disorders. However, to improve clinical treatment, we answer questions about how TMS interacts with and identify its mechanisms. Such fundamental are effectively not possible in humans thus require experiments different species gain insights into...