A5090815327- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Animal Virus Infections Studies
- Lipid Membrane Structure and Behavior
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- RNA Research and Splicing
- MicroRNA in disease regulation
- HIV Research and Treatment
Biologie Tissulaire et Ingénierie Thérapeutique
2022-2024
Université Claude Bernard Lyon 1
2022-2024
Centre National de la Recherche Scientifique
2018-2024
Universidade Federal de Minas Gerais
2016-2022
Unité de Technologies Chimiques et Biologiques pour la Santé
2018-2022
Université Paris Cité
2018-2020
Inserm
2018-2020
Université Paris Sciences et Lettres
2018-2019
Chimie ParisTech
2018-2019
Délégation Paris 5
2018-2019
mRNA-based vaccines have made a leap forward since the SARS-CoV-2 pandemic and are currently used to develop anti-infectious therapies. If selection of delivery system an optimized mRNA sequence two key factors reach in vivo efficacy, optimal administration route for those remains unclear. We investigated influence lipid components immunization regarding intensity quality humoral immune responses mice. The immunogenicity HIV-p55Gag encoded encapsulated into D-Lin-MC3-DMA or GenVoy-ionizable...
Nanomedicine as a therapeutic approach for pregnancy-related diseases could offer improved treatments the mother while avoiding side effects fetus. In this study, we evaluated potential of liposomes carriers small interfering RNAs to placental cells. Three neutral formulations carrying rhodamine-labelled siRNAs were on an in vitro model, i.e., human primary villous cytotrophoblasts. siRNA internalization rate from lipoplexes compared one presence lipofectamine reagent and assessed by...
Currently, most nonviral nucleic acid vectors are in the form of colloidal suspensions administered primarily parenterally. This type formulation and mode administration impose strong constraints such as size or production sterile preparations. The tablet provides access to easy oral administration, well accepted by patients; As regards vectors, a dry represents an advance terms stability. Using optimized lipid-based small interfering RNA-delivery system, we studied tabletability liquid...
Polymeric and/or lipid platforms are promising tools for nucleic acid delivery into cells. We previously reported a lipid-polymer nanocarrier, named LipoParticles, consisting of polylactic nanoparticles surrounded by cationic lipids, and allowing the addition mRNA LAH4-1 peptide at their surface. Although this platform has shown results in vitro terms translation, bulk method used to prepare LipoParticles relies on multistep time-consuming procedure. Here, we developed an automated process...