A5014666234- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Toxoplasma gondii Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Hemoglobinopathies and Related Disorders
- Research on Leishmaniasis Studies
- Blood Coagulation and Thrombosis Mechanisms
- Parasites and Host Interactions
- Blood groups and transfusion
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Viral Infections and Outbreaks Research
- Heme Oxygenase-1 and Carbon Monoxide
- Iron Metabolism and Disorders
- HIV Research and Treatment
- Travel-related health issues
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
Mère et Enfant en Milieu Tropical
2021-2025
Université Paris Cité
2021-2025
Institut de Recherche pour le Développement
2010-2025
Sorbonne Paris Cité
2025
Inserm
2025
Institut National des Recherches Agricoles du Bénin
2020
Université d'Abomey-Calavi
2011-2017
Institut de Recherche pour le Développement
2010
Abstract Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to placental tissue. Binding mediated VAR2CSA, a parasite antigen coded the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Antibody-mediated immunity acquired during successive pregnancies, but target of VAR2CSA-specific protective antibodies unclear. We assessed in pregnant women analyzed their relationships protection...
Binding to chondroitin sulfate A by VAR2CSA, a parasite protein expressed on infected erythrocytes, allows placental sequestration of Plasmodium falciparum-infected erythrocytes. This leads severe consequences such as maternal anemia, stillbirths, and intrauterine growth retardation. The latter has been clearly associated increased morbidity mortality the infants. Acquired anti-VAR2CSA antibodies have with improved pregnancy outcomes, suggesting vaccine could prevent syndrome. However,...
Acquired protection from Plasmodium falciparum placental malaria, a major cause of maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. erythrocyte membrane protein 1 variant VAR2CSA. This enables adhesion falciparum-infected erythrocytes to chondroitin sulfate A in intervillous space. Although interclonal variation var2csa gene lower than that among var genes general, VAR2CSA-specific Abs appear target mainly polymorphic epitopes. has raised doubts about feasibility...
Plasmodium falciparum-infected erythrocytes (IEs) adhere to host cell receptors, allowing parasites sequester into deep vascular beds of various organs. This defining phenomenon malaria pathogenesis is key the severe clinical complications associated with cerebral and placental malaria. The principal ligand binding chondroitin sulfate A (CSA) that allows sequestration IEs a P. falciparum erythrocyte membrane protein 1 (PfEMP1) family member encoded by var2csa gene.Here, we investigated...
Plasmodium falciparum and Toxoplasma gondii are two apicomplexan parasites that can lead to severe complications for the newborn when contracted during pregnancy. This study explores cross-reactivity of antibodies specific both pathogens in pregnant women, exposed or not malaria. The antibody response against full-length recombinant antigens from P. (PfAMA1, Pfs48/45) T. (TgAMA1, TgSAG1, TgGRA7), selected their strong immunogenicity, was analysed on 150 plasma samples women residing Benin...
Globally distributed with variable prevalence depending on geography, toxoplasmosis is a zoonosis caused by an obligate intracellular protozoan parasite, Toxoplasma gondii. This disease usually benign but poses risk for immunocompromised people and newborns of mothers primary infection during pregnancy because the congenital (CT). CT can cause severe damage to fetuses-newborns. To our knowledge, no study has been conducted in sub-Saharan Africa seroprevalence, seroconversion large...
Abstract Background Acquired immunity to Plasmodium falciparum malaria is mainly mediated by immunoglobulin G (IgG) targeting erythrocyte membrane protein 1 (PfEMP1). These adhesins mediate infected (IE) sequestration, protecting IEs from splenic destruction. PfEMP1-specific IgG therefore thought protect inhibiting IE sequestration. VAR2CSA-type PfEMP1 mediates placental putting pregnant women exposed P parasites at risk of (PM). Methods Levels and Fc-afucosylation VAR2CSA-specific plasma...
Sequestration of Plasmodium falciparum -infected erythrocytes expressing the VAR2CSA antigen in placenta results poor pregnancy outcomes, including low birth weight and maternal anemia. Antigen-specific antibody-mediated immunity is acquired during successive pregnancies. Thus, evaluating VAR2CSA-specific IgG profiles among pregnant women will increase knowledge on immunological mechanisms associated with protection, help development VAR2CSA-based placental malaria vaccines. Using PAMVAC...
Abstract Background Sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria but not placental (PM). In this study, P erythrocyte membrane protein (PfEMP1)-specific antibodies were measured in HbAA and HbAS Beninese pregnant women as a proxy of exposure to specific PfEMP1 variants. Methods Plasma samples collected at delivery from 338 63 used measure immunoglobulin (Ig)G levels 6 recombinant proteins 3 corresponding native expressed on the infected (IE) surface....
Immunological protection against Plasmodium falciparum blood stages is mainly antibody mediated [1,2]. Variant surface antigens (VSA) expressed on the of P. falciparum-infected red cells constitute a key for parasite sequestration and immune evasion [3]. In distinct malaria clinical presentations, as placental malaria, specific response VSA provides [4]. In current study, we investigated in groups patients, specifically directed by parasites isolated from given presentation, particularly...
Abstract Background Variant surface antigens (VSA) expressed on the of Plasmodium falciparum -infected red blood cells constitute a key for parasite sequestration and immune evasion. In distinct malaria pathologies, such as placental malaria, specific antibody response against VSA provides protection. This study investigated specifically directed by parasites isolated from individuals presenting given type clinical presentation. Methods Plasma isolates were obtained four groups Beninese...
Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing survival during febrile episodes. Resa1 gene is a member of small family comprising three highly related genes. Preliminary evidence led search for clues indicating involvement RESA2 protein in pathophysiology malaria. In present study, cDNA sequence resa2 was obtained from two different strains. The proportion P. isolates...
Hemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, effect HbAC on antibody response to malaria antigens pregnancy has not been studied. Here, we measured PfEMP1-specific antibodies plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition VAR2CSA+ infected erythrocytes adhesion chondroitin sulfate A (CSA) was also tested. IgG levels VAR2CSA were significantly lower...
The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair detection and assignment to one or another protein some pathogenic processes inherent Plasmodium falciparum malaria. present study was intended determine if antibody inflammatory responses children living in a malaria-endemic area varied depending on RESA-1, RESA-2 RESA-3 severity disease, two groups severe uncomplicated malaria cases being considered. Two...
<title>Abstract</title> <italic>Plasmodium falciparum</italic> and <italic>Toxoplasma gondii</italic> are two parasitic species affecting humans, that can lead to severe complications for the newborn when contracted during pregnancy. This study explores cross-reactivity of antibodies specific both pathogens in pregnant women belonging population groups either exposed (Benin) or non-exposed (France) malaria. The antibody response against antigens from <italic>P. <italic>T. was analysed on...