A5025360451- Malaria Research and Control
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Diabetes and associated disorders
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Complement system in diseases
- Insect Resistance and Genetics
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Endometriosis Research and Treatment
- Reproductive Physiology in Livestock
- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Parasite Biology and Host Interactions
- Advanced Glycation End Products research
- Drug Transport and Resistance Mechanisms
- Parasites and Host Interactions
- Retinal Development and Disorders
- Helminth infection and control
- Cassava research and cyanide
Université d'Abomey-Calavi
2013-2022
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
2018
Université de Bourgogne
2003-2008
Max Planck Institute for Brain Research
1998
Max Planck Society
1998
Saarland University
1993
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
1988
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
1988
Not much is known about the implication of adipokines and different cytokines in gestational diabetes mellitus (GDM) macrosomia. The purpose this study was to assess profile these hormones macrosomic babies, born diabetic women.A total 59 women (age, 19-42 yr) suffering from GDM with their babies (4.35 +/- 0.06 kg) 60 healthy age-matched pregnant newborns (3.22 0.08 were selected.Serum (adiponectin leptin) quantified using an obesity-related multiple ELISA microarray kit. concentrations...
Knowledge on the spread and distribution of insecticide resistance in major malaria vectors such as Anopheles funestus is key to implement successful management strategies across Africa. Here, by assessing susceptibility status an inland population An. Giles (Kpome) investigating molecular basis resistance, we show that multiple consistent plasmodium infection rate are present populations from Kpome. The level collected was assessed. Synergist (PBO) used screen mechanisms. TaqMan technique...
Immunological tolerance is one of the fundamental aspects immune system. The CD4(+)CD25(+) regulatory T (Treg) cells have emerged as key players in development to self and foreign antigens. However, little known about endogenous factors mechanisms controlling their suppressive capacity on response. In this study, we observed that docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, diminished, a dose-dependent manner, Treg inhibit CD4(+)CD25(-) effector T-cell proliferation. DHA...
Background: The role of the immune system in insulin resistance associated with type 2 diabetes has been suggested.Objectives: We assessed profile Th1/Th2 cytokines along frequencies cells insulin-treated diabetic patients (T2DP).Methods: 45 T2D and 43 age-matched healthy subjects were selected. Serum concentrations T-helper 1 (Th1) Th2 innate adaptive immunity assessed.Results: T2DP hyperglycemic showed high level insulin, normal levels triglycerides total-cholesterol without any change...
Abstract Most non‐primate mammals have two types of cone: short‐wavelength sensitive (S) and middle‐to‐long‐wavelength (M/L) cones. In species African giant rats, Cricetomys gambianus C. emini , in earless seals, Phoca hispida P. vitulina the retinal cone distributions were assessed with antibodies specific for M/L‐cone opsin S‐cone opsin, respectively. All four found to completely lack S‐cones, while M/L‐cones present low densities. densities, rod densities cone/rod ratios determined across...
Populations in Africa mostly rely on herbal concoctions for their primarily health care, but so far scientific studies supporting the use of plants traditional medicine remain poor. The present study was undertaken to evaluate anti-hyperglycemic effects Picralima nitida (seeds), Nauclea latifolia (root and stem) Oxytenanthera abyssinica (leaves) commonly used, diabetic pregnancy.Pregnant wistar rats, rendered by multiple low injections streptozotocin, were treated with selected plant...
Protection from infections in early life relies extensively on innate immunity, but it is unknown whether and how maternal modulate infants' immune responses, thereby altering susceptibility to infections. Plasmodium falciparum causes pregnancy-associated malaria (PAM), epidemiological studies have shown that PAM enhances infection with P. falciparum. We investigated PAM-mediated exposures utero affect responses their relationship infancy. In a prospective study of mothers babies Benin, we...
We assessed the implication of peroxisome proliferator-activated receptor (PPAR) α deficiency in pregnancy outcome and neonatal survival modulation T cell differentiation murine diabetic their offspring. Pregnant wild-type (WT) PPARα-null mice C57BL/6J genetic background were rendered by five low doses streptozotocin. observed that, absence diabetes, PPARα resulted an increase abortion rate, i.e. 0% WT vs. 20% [odds ratio (OR) = 14.33; P 0.013]. Under conditions, rate was enhanced, 8.3% 50%...
The immunosuppressive properties of HLA-G protein can create a tolerogenic environment that may allow Plasmodium falciparum to avoid host immune responses. There are known associations between high levels circulating soluble (sHLA-G) and either parasite or viral infections it has been suggested the induction sHLA-G expression could be mechanism via which infectious agents subvert defence. study presented here is first investigate possible association malaria related risk factors in Benin. A...
Insecticide resistance in Anopheles mosquitoes is threatening the success of malaria control programmes. In order to implement suitable insecticide management strategies, it necessary understand underlying mechanisms involved. To achieve this, molecular basis permethrin and DDT principal vector, funestus from inland Benin (Kpome), was investigated. Here, using a microarray-based genome-wide transcription qRT-PCR analysis, we showed that metabolic through over-expression cytochrome P450...
Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps protect against malaria and other infections in infancy. Recent studies have emphasized important role malaria-specific IgG3 immunity, its may reduce risk Human IgGs are actively transferred across placenta by binding neonatal Fc receptor (FcRn) expressed within endosomes syncytiotrophoblastic membrane. Histidine at position 435 (H435) provides for optimal Fc-IgG binding. In contrast IgG subclasses, is highly...
Abstract The in vitro effects of extracts four tropical plants ( Zanthoxylum zanthoxyloides , Newbouldia laevis, Morinda lucida and Carica papaya ) on the egg, infective larvae adult worms Trichostrongylus colubriformis were screened for potential anthelmintic properties. Significant observed with T. but they differed depending stage parasite. Extracts each plant induced a dose-dependent inhibition egg hatching. Using larval migration test, also detected extracts. In contrast, worms,...
Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to evasion has been established. A first study conducted Benin shown that production of soluble HLA-G (sHLA-G) months life strongly correlated with maternal level at delivery and associated low birth weight malaria. However sHLA-G measurements pregnancy were not available for mothers furthermore, date evolution documented...
To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition antibody responses among infants living endemic areas.Five hundred sixty-seven Beninese weekly followed-up from birth 18 months age. Immunoglobulin G (IgG), IgG1 IgG3 specific for 5 antigens measured every 3 months. A linear mixed model was used analyze...
Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody infants naturally-exposed malaria will allow better understand the establishment of anti-malarial and contribute vaccine development by identifying most appropriate candidate antigens.The study was based on parasitological clinical active follow-up birth 18 months age...
Background Helminths can modulate the host immune response to Plasmodium falciparum and therefore affect risk of clinical malaria. We assessed here effect helminth infections on both immunogenicity efficacy GMZ2 malaria vaccine candidate, a recombinant protein consisting conserved domains GLURP MSP3, two asexual blood-stage antigens P . Controlled human infection (CHMI) was used assess vaccine. Methodology In randomized, double-blind Phase I trial, fifty, healthy, lifelong malaria-exposed...