A5070599275- Neuroscience and Neuropharmacology Research
- Autoimmune Neurological Disorders and Treatments
- Cellular transport and secretion
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Cholesterol and Lipid Metabolism
- Photoreceptor and optogenetics research
- Drug Transport and Resistance Mechanisms
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Genetic Neurodegenerative Diseases
- Complement system in diseases
- Glycogen Storage Diseases and Myoclonus
- Advanced Memory and Neural Computing
- Neurological disorders and treatments
- Simulation Techniques and Applications
- Ion channel regulation and function
Centre National de la Recherche Scientifique
2021-2024
Assistance Publique – Hôpitaux de Paris
2021-2024
Sorbonne Université
2021-2024
Inserm
2021-2024
Pitié-Salpêtrière Hospital
2021-2023
Institut du Cerveau
2021-2023
Laboratoire de Mathématiques d'Orsay
2015
Lance-Adams syndrome (LAS), or chronic posthypoxic myoclonus, is a long-term disabling neurologic disorder occurring in survivors of anoxia. The cortical subcortical origin this myoclonus unclear. We aimed to identify the neuroanatomical LAS.
Magnetic brain stimulation is a promising treatment for neurological and psychiatric disorders. However, better understanding of its effects at the individual neuron level essential to improve clinical application. We combined focal low-intensity repetitive transcranial magnetic (LI-rTMS) rat somatosensory cortex with intracellular recordings subjacent pyramidal neurons in vivo. Continuous 10 Hz LI-rTMS reliably evoked firing ∼4-5 during period induced durable attenuation synaptic activity...
Abstract Autoimmune encephalitis (AIE) associated with antibodies directed against the leucine-rich glioma inactivated 1 (LGI1) protein is second most common AIE and responsible for deleterious neocortical limbic epileptic seizures. Previous studies demonstrated a pathogenic role of anti-LGI1 via alterations in expression function Kv1 channels AMPA receptors. However, causal link between seizures has never been demonstrated. Here, we attempted to determine human autoantibodies genesis by...
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is major importance. Changes brain cholesterol homeostasis an emerging candidate for excitotoxicity. We conducted overall analysis both (i) in fluids and tissues from patients SE: blood (n = 63, n 87 controls), CSF 32, 60 post-mortem 8, 8 controls) (ii) mouse model SE induced by intrahippocampal injection kainic acid. 24-hydroxycholesterol levels were decreased acid hippocampus human plasma when...
The neocortex is highly susceptible to metabolic dysfunction. When exposed global ischemia or anoxia, it suffers a slowly propagating wave of collective neuronal depolarization that ultimately impairs its structure and function. While the molecular signature anoxic (AD) well documented, little known about brain states precede follow AD onset. Here, by means multisite extracellular local field potentials intracellular recordings from identified pyramidal cells, we investigated laminar...
Abstract Magnetic brain stimulation is a promising treatment for neurological and psychiatric disorders. However, better understanding of its effects at the individual neuron level essential to improve clinical application. We combined focal low-intensity repetitive transcranial magnetic (LI-rTMS) rat somatosensory cortex with intracellular recordings subjacent pyramidal neurons in vivo . Continuous 10 Hz LI-rTMS reliably evoked firing ∼4-5 during period induced durable attenuation synaptic...