A5065680357- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Muscle activation and electromyography studies
- Hearing Loss and Rehabilitation
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Angiogenesis and VEGF in Cancer
- Cellular transport and secretion
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
The University of Western Australia
2016-2025
Perron Institute for Neurological and Translational Science
2016-2025
Queen Elizabeth II Medical Centre
2015-2024
Kazakh National Medical University
2024
Kazakh Institute of Oncology and Radiology
2024
St. Paul's Hospital Millennium Medical College
2023
Ear Science Institute Australia
2019
Bernstein Center for Computational Neuroscience Göttingen
2019
University of Göttingen
2019
Cancer Council NSW
2016-2018
Ceramide, a key intermediate in sphingolipid metabolism, is synthesized by acylation of sphinganine followed dehydrogenation dihydroceramide to ceramide. Using radioactive sphinganine, we have examined the site and topology synthesis well-characterized subcellular fractions from rat liver. [4,5-3H]Sphinganine was introduced as complex with BSA metabolized [4,5-3H]dihydroceramide upon incubation liver homogenates or microsomes fatty acyl CoA. Conditions were established detergent-free system...
Since the development of transcranial magnetic stimulation (TMS) in early 1980s, a range repetitive TMS (rTMS) protocols are now available to modulate neuronal plasticity clinical and non-clinical populations. However, despite wide application rTMS humans, mechanisms underlying rTMS-induced remain uncertain. Animal vitro models provide an adjunct method investigating potential synaptic non-synaptic plasticity. This review summarizes experimental studies, vivo studies with intact rodents,...
Hearing loss from acoustic trauma is a risk factor for tinnitus. Animal models using have demonstrated hyperactivity in central auditory pathways, which has been suggested as substrate We used guinea-pig model of unilateral trauma. Within the same animals, measurements peripheral hearing loss, spontaneous activity single neurons inferior colliculus and gene expression cochlear nucleus were combined, acutely after recovery Genes investigated related to inhibitory (GABA-A receptor subunit...
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field focused on target region during rTMS, adjacent areas also receive at lower intensity contribution of this perifocal to network-wide effects poorly defined. Here, we examined low-intensity rTMS (LI-rTMS)-induced changes model neural network using visual systems normal (C57Bl/6J wild-type, n = 22) ephrin-A2A5(-/-) (n mice, latter...
Although the organization of neuronal circuitry is shaped by activity patterns, capacity to modify and/or optimize structure and function whole projection pathways using external stimuli poorly defined. We investigate whether induced pulsed magnetic fields (PMFs) alters brain function. delivered low-intensity PMFs posterior cranium awake, unrestrained mice (wild-type ephrin-A2A5 -/-) that have disorganized retinocollicular associated visuomotor deficits. Control groups each genotype received...
Similar to neurons in the peripheral nervous system, immature CNS-derived RGCs become dependent on target-derived neurotrophic support as their axons reach termination sites brain. To study factors that influence this developmental transition we took advantage of fact rat are born, and target innervation occurs, over a protracted period time. Early-born have SC by birth (P0), whereas from late-born do not innervate until P4-P5. Birth dating using EdU allowed us identify (1) with still...
Abstract The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss the translational activator cytochrome oxidase subunit I (TACO1). We report TACO1 is not required for embryonic survival, although mutant have substantially reduced COXI protein, causing an isolated complex IV deficiency. show specifically binds mt-Co1 mRNA through its...
Central nervous system myelination increases action potential conduction velocity. However, it is unclear how coordinated to ensure the temporally precise arrival of potentials and facilitate information processing within cortical associative circuits. Here, we show that myelin sheaths, supported by mature oligodendrocytes, remain plastic in adult mouse brain undergo subtle structural modifications influence Repetitive transcranial magnetic stimulation spatial learning, two stimuli modify...
Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific have previously been used to deliver focal at cost stimulus intensity (12mT). Here we describe two novel coils designed repetitive (rTMS) greater intensities whilst maintaining spatial resolution. Two circular (8 mm outer diameter) were constructed with either an air or pure iron core. Peak field strength...
Abstract Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) delivered to noninvasively modulate neuronal activity; however, the ability rTMS facilitate adaptive myelination has not been explored. By performing cre‐lox lineage tracing, follow fate progenitor cells in adult mouse brain, we determined that low intensity (LI‐rTMS), administered as an intermittent...
Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of effects impaired function reduced production Brain Derived Neurotrophic Factor (BDNF), protein required normal neuronal When housed an enriched environment, null mice improved abilities increased levels BDNF brain. We investigated environmental enrichment on gross skills blood girls syndrome. A genetically variable group 12 younger than 6 years participated...
Abstract Prior research suggests that the neurobiological underpinnings of depression include aberrant brain functional connectivity, neurometabolite levels, and hippocampal volume. Chronic restraint stress (CRS) model in rats has been shown to elicit behavioral, gene expression, protein, volume changes similar those human depression. However, no study date examined association between behavioral within same animals. This specifically addressed correlation outcomes tests multiple 9.4 T...
Abstract The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address fundamental question we used CRISPR editing to knockout seven-membered phenylalanine gene family mice, both individually combinatorially. Using ATAC-Seq, RNA-seq, ribo-profiling proteomics observed distinct consequences single deletions. We show that tRNA-Phe-1-1 is required neuronal function its loss partially...
Animals live in environments that are both complex and continually changing, so they have to respond short- long-term variations a wide range of factors, such as photoperiod, nutrition sociosexual signals. Before were domesticated, animals developed reproductive strategies coped with these changes often took advantage them. The physiological processes implement been modified some extent during several millennia controlled breeding, but most persist. Thus, many genotypes still exhibit...
In many species, the reproductive centers of brain are profoundly affected by sociosexual stimuli. This is particularly evident in female ungulates such as sheep, which exposure to males switches them from reproductively quiescent fertile. two experiments with we tested whether that control gonadotropin-releasing hormone (GnRH) neuronal activity respond differentially "novel" vs. familiar and neuroendocrine response associated increased cell proliferation hippocampus, a site memory...
The field of pharmacogenetics (PGx) is experiencing significant growth, with increasing evidence to support its application in psychiatric care, suggesting potential personalize treatment plans, optimize medication efficacy, and reduce adverse drug reactions. However, the perceived utility practicability PGx for youth remains underexplored. This study investigated barriers attitudes Australian young adults towards implementation testing guide antidepressant primary care. Semi-structured...