A5074702201- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Neural dynamics and brain function
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Adipose Tissue and Metabolism
- Renal and related cancers
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Animal Genetics and Reproduction
- Retinal Development and Disorders
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- Supramolecular Self-Assembly in Materials
- Force Microscopy Techniques and Applications
- Neuroscience and Neural Engineering
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
Menzies School of Health Research
2019-2024
Menzies Institute for Medical Research
2024
University of Tasmania
2018-2021
Central nervous system myelination increases action potential conduction velocity. However, it is unclear how coordinated to ensure the temporally precise arrival of potentials and facilitate information processing within cortical associative circuits. Here, we show that myelin sheaths, supported by mature oligodendrocytes, remain plastic in adult mouse brain undergo subtle structural modifications influence Repetitive transcranial magnetic stimulation spatial learning, two stimuli modify...
Abstract Axons are ultrathin membrane cables that specialized for the conduction of action potentials. Although their diameter is variable along length, how morphology determined unclear. Here, we demonstrate unmyelinated axons mouse central nervous system have nonsynaptic, nanoscopic varicosities ~200 nm in repeatedly length interspersed with a thin cable ~60 like pearls-on-a-string. In silico modeling suggests this axon nanopearling can be explained by mechanical properties. Treatments...
Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface receptor that highly expressed by oligodendrocyte progenitor cells (OPCs) and LRP1 expression rapidly downregulated as OPCs differentiate into oligodendrocytes (OLs). We report the conditional deletion of Lrp1 from adult mouse (Pdgfrα-CreER :: fl/fl ) increases number newborn, mature myelinating OLs added to corpus callosum motor cortex. As these additional extend normal internodes are length,...
Abstract Primary cilia are small microtubule‐based organelles capable of transducing signals from growth factor receptors embedded in the membrane. Developmentally, oligodendrocyte progenitor cells (OPCs) express genes associated with primary assembly, disassembly, and signaling, however, importance for adult myelination has not been explored. We show that OPCs ciliated vitro vivo, they disassemble their as progress through cell cycle. OPC also disassembled differentiate into...
Abstract Axons are thought to be ultrathin membrane cables of a relatively uniform diameter, designed conduct electrical signals, or action potentials. Here, we demonstrate that unmyelinated axons not simple cylindrical tubes. Rather, have nanoscopic boutons repeatedly along their length interspersed with thin cable diameter ∼60 nm like pearls-on-a-string. These only ∼200 in and do synaptic contacts cluster vesicles, hence non-synaptic. Our silico modeling suggests axon pearling can...
Neurotransmitter is released from dedicated sites of synaptic vesicle fusion within a synapse. Following fusion, the vacated are replenished immediately by new vesicles for subsequent neurotransmission. These replacement assumed to be located near release and used chance. Here, we find that clustered around this region Intersectin-1. Specifically, Intersectin-1 forms dynamic molecular condensates with Endophilin A1 sequesters region. In absence Intersectin-1, 20 nm plasma membrane reduced,...
Abstract Glutamate-gated kainate receptors comprising the Gluk4 subunit (encoded by Grik4 ) are highly expressed neurons in central nervous system. We report that mRNA is widely adult mouse motor cortex, where GluK4-containing account for ∼60% of evoked current layer V pyramidal neurons. To elucidate their role circuit regulation, we analysed behaviour mice lacked pore forming domain GluK4 ( -/- mice). were hyperactive, had an abnormal gait, and impaired coordination. At postnatal day (P)60,...
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Summary Central nervous system myelination increases action potential conduction velocity, however, it is unclear how coordinated to ensure the temporally precise arrival of potentials, and facilitate information processing within cortical associative circuits. Here, we show that mature myelin remains plastic in adult mouse brain can undergo subtle structural modifications influence times. Repetitive transcranial magnetic stimulation spatial learning, two stimuli modify neuronal activity,...
Abstract Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface receptor that highly expressed by oligodendrocyte progenitor cells (OPCs), and LRP1 expression rapidly downregulated as OPCs differentiate into oligodendrocytes (OLs). We report the conditional deletion of Lrp1 from adult mouse ( Pdgfrα-CreER :: fl/fl ) increases number new myelinating OLs added to brain, but each elaborates normal quantity myelin. OPC proliferation also elevated following...