A5077743220- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Neuroscience and Music Perception
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Marine animal studies overview
- Neuroscience and Neural Engineering
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Microfluidic and Bio-sensing Technologies
- Neurobiology of Language and Bilingualism
- Nicotinic Acetylcholine Receptors Study
- Bat Biology and Ecology Studies
- Microfluidic and Capillary Electrophoresis Applications
- Multisensory perception and integration
- Acoustic Wave Resonator Technologies
- Animal Vocal Communication and Behavior
- Acoustic Wave Phenomena Research
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- EEG and Brain-Computer Interfaces
University of South Florida
2015-2024
Barts Health NHS Trust
2023-2024
Royal London Hospital
2023-2024
United States Navy
2022
United States Department of the Navy
2022
Mountain Home VA Healthcare System
2013
National Institute on Deafness and Other Communication Disorders
2013
Northwestern University
2013
Medical University of South Carolina
2013
University of California, San Francisco
2013
The perception of complex sounds, such as speech and animal vocalizations, requires the central auditory system to analyze rapid, ongoing fluctuations in sound frequency intensity. A decline temporal acuity has been identified one component age-related hearing loss. detection short, silent gaps is thought reflect an important fundamental dimension resolution. In this study we compared neural response elicited by imbedded noise single neurons inferior colliculus (IC) young old CBA mice. IC...
Recreational use of nitrous oxide (N2O) has increased rapidly in recent years and is now the second most commonly used recreational drug among young people UK. There been a corresponding rise cases oxide-induced subacute combined degeneration cord (N2O-SACD), pattern myeloneuropathy usually associated with severe vitamin B12 deficiency. This can cause serious permanent disability but, if recognised early, may be effectively treated. All neurologists should aware N2O-SACD its treatment;...
This research was guided by the working hypothesis that aging auditory system progressively loses its ability to process rapid acoustic transients efficiently, and in elderly listeners, this results difficulties speech perception. Neural correlates of age-related deficits temporal processing were investigated recording from inferior colliculus (IC) neurons young adult old CBA mice. Single-unit responses recorded sinusoidally amplitude-modulated (SAM) noise carriers, presented at 65–80 dB...
Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; affects hundreds millions people worldwide. Its prevalence close to that cardiovascular arthritis, can be a precursor dementia. The auditory perceptual dysfunction well understood, but knowledge biological bases ARHL still somewhat lacking. Surprisingly, there are no FDA-approved drugs for treatment. Based on previous studies human...
Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific have previously been used to deliver focal at cost stimulus intensity (12mT). Here we describe two novel coils designed repetitive (rTMS) greater intensities whilst maintaining spatial resolution. Two circular (8 mm outer diameter) were constructed with either an air or pure iron core. Peak field strength...
Infants with the diagnosis of persistent fetal circulation were evaluated for hearing loss. From Jan 1, 1982, to 1984, 28 infants this retrospectively identified, and 18 by formal audiologic testing. Additionally, 22 prospectively followed serial auditory evaluation from 1986. Of 40 evaluated, 21 identified as having impairment (52.5%), 14 whom required aids. For 82% those hearing-impaired who aids, parental concern was expressed their lack acuity. This factor could have aided in earlier...
Cognitive event-related potentials (ERPs) were measured during a timbre discrimination task from three subject groups varying in musical experience. The P3 component of the ERP was recorded musicians with absolute pitch, without and nonmusicians comprising timbres difficulty. three-timbre series, all which consisted same (1) string instruments family (cello viola), (2) flutes made different materials (silver wood), (3) slightly size (B-flat versus F tubas). amplitude latency varied...
Background The study aimed to elucidate the prevalence of nitrous oxide (N2O) usage in patients with unexplained venous thromboembolism (VTE), highlighting potential association hyperhomocysteinaemia (HHcy). Methods We conducted a retrospective at Royal London Hospital, examining cases N2O-related VTE from March August 2023. Among 50 identified, four (8%) had recent unprovoked VTE. Patient data were collected based on N2O ambulatory emergency care pathway admissions. Results or concurrent...
Abstract Low‐level lead (Pb) exposure is a risk factor for learning disabilities, attention deficit hyperactivity disorder (ADHD), and other neurological dysfunction. It not known how Pb produces these behavioral deficits, but low‐level during development associated with auditory temporal processing deficits in an avian model, while hearing thresholds remain normal. Similar are found children disabilities ADHD. To identify cellular changes underlying this functional deficit, Pb‐induced...
Iron is critical in multiple aspects of CNS development, but its role neurodevelopment—the ability iron deficiency to alter normal development—is difficult dissociate from the effects anemia. We developed a novel dietary restriction model rat that allows us study absence severe Using combination auditory brainstem response analyses (ABR) and electron microscopy, we identified an unexpected impact nonanemic on axonal diameter neurofilament regulation nerve. These changes are associated with...
Chronic tinnitus, or “ringing of the ears”, affects upwards 15% adult population. Identifying a cost-effective and objective measure tinnitus is needed due to legal concerns disability issues, as well for facilitating effort assess neural biomarkers. We developed modified gap-in-noise (GIN) paradigm in mice using auditory brainstem response (ABR). then compared commonly used acoustic startle reflex gap-prepulse inhibition (gap-PPI) ABR GIN young CBA/CaJ before after administrating sodium...
The neural correlates of music perception have received relatively little scientific attention. activity listeners without musical training (N=11), highly trained musicians (N=14), and possessing ‘‘absolute pitch’’ (AP) ability (N=10) been measured. Major differences were observed in the P3, an endogenous event-related potential (ERP), which is thought to be a neurophysiological manifestation working memory processing. P3 was elicited using classical ‘‘oddball’’ paradigm with sine-tone...
The purpose of this study was to examine the incidence, profile, and stability sensorineural hearing loss (SNHL) in infants diagnosed with persistent pulmonary hypertension newborn (PPHN). Over a five-year period, 19 51 (37%) PPHN were SNHL: 16 bilateral 3 unilateral impairment. This incidence SNHL is approximately 25 times greater than observed graduates our intensive care nursery. profile group children typically downward sloping. However, there considerable variation respect degree loss....
Objective: This study was designed to evaluate an automated pure-tone audiometric procedure (AMTAS®) for 4–8 year-old children, and a quality assessment method (QUALIND®) that predicts the accuracy of test. Design: Children were tested with AMTAS conventional manual air-conduction audiometry. A group adults comparison. Study sample: Eighty-one children 15 adults. Most had normal hearing. Results: For most subjects (93% 91% children) differences between thresholds similar occur when two...
Sodium/potassium/chloride cotransporter (NKCC1) proteins play important roles in Na + and K concentrations key physiological systems, including cardiac, vascular, renal, nervous, sensory systems. NKCC1 levels functionality are altered certain disease states, tend to decline with age. A sensitive, effective way of regulating protein expression has significant biotherapeutic possibilities. The purpose the present investigation was determine if naturally occurring hormone aldosterone (ALD)...