A5061246764- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Sports Performance and Training
- Exercise and Physiological Responses
- Sports injuries and prevention
- Genetics and Physical Performance
- Iron Metabolism and Disorders
- Physical Activity and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Disease and Adiposity
- Body Composition Measurement Techniques
- Knee injuries and reconstruction techniques
- Advanced Chemical Sensor Technologies
- Nuclear Structure and Function
- Winter Sports Injuries and Performance
- Nutrition, Genetics, and Disease
- Toxic Organic Pollutants Impact
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Diet and metabolism studies
Université Paris Cité
2015-2025
Université du Québec à Montréal
2018-2025
Université de Reims Champagne-Ardenne
2018-2025
Inserm
2007-2025
University of Jordan
2025
Institut National du Sport, de l'Expertise et de la Performance
2015-2024
Performance Santé, Métrologie, Société
2022-2024
Sorbonne Paris Cité
2013-2023
Toxicologie, Pharmacologie et Signalisation Cellulaire
2018-2023
Institut de Recherche bio-Médicale et d'Epidémiologie du Sport
2014-2023
Abstract In this study, using a high‐resolution gel electrophoresis technique, we have characterized the myosin heavy chain composition in different skeletal muscle of mouse during postnatal development. The pattern expression was studied four hind limb muscles, diaphragm, tongue and masseter. All these muscles displayed usual sequential transitions from embryonic to neonatal adult isoforms but more interestingly occur with distinct chronology muscles. addition, our results demonstrated...
How to assess mental load remains a recurrent question. We aimed explore whether slight differences in real-world driving task demands could be discriminated by electrodermal response (EDR). A sample of 33 participants was observed under five conditions: controlled braking from 50 30 km/h, 80 0 and single unexpected emergency event km/h. The likelihood EDR and, whenever present, its duration were both correlated with workload as represented the deceleration demand. higher base travel speed...
To compare the effects of high-intensity interval training (HIIT) alone vs. HIIT combined with L-citrulline (CIT) supplementation on functional capacity and muscle function in dynapenic-obese elderly.A total 56 obese (fat mass: men > 25%, women 35%) dynapenic (grip strength/body weight: < 0.44, 0.61) subjects were recruited divided two groups: HIIT+CIT (n = 26; age: 6 5 ± four years) HIIT+Placebo (PLA, n 30; 68 years). Participants followed a 12-week using an elliptical trainer. took single...
Abstract The age-performance relationship describes changes in the organism’s structural and functional capabilities over course of lifespan. typical, empirical pattern is an asymmetrical inverted-U shape association with peak capacity occurring early life. This process well described literature, increasing interest features that characterize this pattern, such as rate growth, age performance, decline aging. usually examined cohorts individuals followed time repeat assessments physical or...
The number of retirements, withdrawals, and "lucky losers" (the replacement a player who withdraws before the start tournament by losing from qualifying round) professional tennis tournaments has increased, but reasons behind such departures have not yet been analyzed. An official consensus statement conducted to allow general categorization injuries in tennis.To determine for departure injury rates tennis.Descriptive epidemiology study.All were collected Association Tennis Professionals...
Citrulline (Cit) actions on muscle metabolism remain unclear. Those latter were investigated using a proteomic approach Tibialis muscles from male Sprague-Dawley rats. At 23 months of age, rats either fed ad libitum (AL group) or subjected to dietary restriction for 12 weeks. the end period, one group was euthanized (R and two groups refed week with standard diet supplemented nonessential amino acids Cit (CIT group). Results validated targeted Western blot analysis assessment gene expression...
Life-span trends progression has worldwide practical implications as it may affect the sustainability of modern societies. We aimed to describe secular life-span populations with a propensity live longer—Olympians and supercentenarians—under two hypotheses: an ongoing extension versus biologic "probabilistic barrier" limiting further progression. In study densities (total number life durations per birth date), we analyzed 19,012 Olympians 1,205 supercentenarians deceased between 1900 2013....
Locomotion is one of the major physiological functions for most animals. Previous studies have described aging mechanisms linked to locomotor performance among different species. However, precise dynamics these age-related changes, and their interactions with development senescence, are largely unknown. Here, we use same conceptual framework describe performances in Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, Homo sapiens. We show that locomotion a consistent...
Sarcopenia and obesity are considered a double health burden. Therefore, the implementation of effective strategies is needed to improve quality life older obese individuals. The aim this study was compare impact high-intensity interval training (HIIT) moderate-intensity continuous (MICT) on functional capacities, muscle function, body composition blood biomarkers in adults. Adipose tissue gene expression markers mitochondrial content control involved exercise adaptations were also...
The purpose of this study was to quantify intermittent training sessions using different types exercise. Strength, sprint, and endurance were performed until exhaustion. These quantified by the product duration heart rate (HR) (i.e., impulse (TRIMP) HR-zone methods), perceived exertion (RPE-based method), a new method (work recovery (WER)). WER aims determine level exercise-induced physiological stress ratio cumulated work – limit, which is associated with naparian logarithm work–recovery....
Scope During aging, increased visceral adipose tissue (AT) mass may result in impaired metabolic status. A citrulline (CIT)‐supplemented diet reduces AT old rats. We hypothesized that CIT could directly affect fatty acid (FA) metabolism retroperitoneal AT. Methods and results 24‐h exposure of explants from (25 months) rats to 2.5 mM induced a 50% rise glycerol FA release, which was not observed young (2 animals. The phosphorylated form hormone‐sensitive lipase, key lipolytic enzyme, 1.5‐fold...
Abstract Physical and cognitive performances change across lifespan. Studying cohorts of individuals in specific age ranges athletic abilities remains essential assessing the underlying physiological mechanisms that result such a drop performance. This decline is now viewed as unique phenotypic biomarker hallmark aging process. The rates are well documented for sets traits running or swimming but only limited number studies have examined developmental senescent phases together. Moreover, few...
Only few studies analyzed real training programs of sprinters while that should be a valuable step in the understanding sprint training. The present study aimed at characterizing track cycling sprinter by load and intensity distribution.Twenty-nine weeks prechampionship data were retrospectively for 6 world-class athletes. Training was measured ratio volume completed to maximal categorized five zones (endurance: zones1-2; sprinting: zones3-5) exercise type (on-bike or resistance). Intra-week...
Persistent organic pollutants (POPs) are known to accumulate in adipose tissues (AT). This storage may be beneficial by diverting POPs from other sensitive or detrimental because of chronic release as indirectly suggested during weight loss. The aim is study the biological and/or toxic effects that POP previously contaminated grafted AT could exert a naïve mouse.C57BL/6J male mice were exposed intraperitoneally 2,3,7,8-tetrachlorodibenzo-p-doxin (TCDD); their epididymal fat pads collected...
Abstract Background Iron excess has been proposed as an essential factor in skeletal muscle wasting. Studies have reported correlations between iron accumulation and atrophy, either through ageing or by using experimental models of secondary overload. However, treatments performed most these studies induced extra‐pathophysiological overload, more representative intoxication poisoning. The main objective this study was to determine the impact closer pathophysiological conditions on structural...
Abstract Acute kidneys injuries (AKIs) have been described in marathon and trail running. The currently available data allows assessment of before/after comparisons but does not allow an analysis what happens during the race. A multidisciplinary protocol was performed first Clécy ( Normandy France ) November 2021. This allowed initial assay to be carried out, then at end each 6 loops 26 km, finally after 24 h recovery. race extends over 156 km hilly terrain 6000 m elevation gain (D+). level...
In the literature, there is an ambiguity as to respective roles played by calcineurin phosphatase activity (CPA) and muscle innervation in reestablishment of slow-twitch phenotype after regeneration different species. this study, we wanted determine role on appearance maintenance slow during mouse regeneration. The pattern myosin expression CPA was analyzed adult (n=15), regenerating (n=45) denervated-regenerating (n=32) soleus fast-twitch extensor digitorum longus (EDL) muscles. Moreover, a...
High-fat diet (HFD) increases visceral adipose tissue (AT). Our aim was to evaluate whether citrulline (CIT) affected nonesterified fatty acid (NEFA) metabolism in AT from HFD-fed rats.Rats were fed for 8 weeks with either a control (CD) or HFD. Retroperitoneal explants exposed 2.5 mmol/L CIT 24 h. We analyzed lipolysis, beta-oxidation, glyceroneogenesis, and the expression of key associated enzymes. doubled NEFA release selectively HFD AT. Phosphorylation hormone-sensitive lipase...