A5053378507- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Dietary Effects on Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Biochemical Analysis and Sensing Techniques
- Bariatric Surgery and Outcomes
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
- Abdominal Surgery and Complications
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gut microbiota and health
- Intestinal and Peritoneal Adhesions
- Circadian rhythm and melatonin
- Cardiovascular Disease and Adiposity
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2015-2025
Yale University
2023-2024
Amsterdam UMC Location University of Amsterdam
2013-2023
Amsterdam Neuroscience
2020-2022
University Medical Center
2019-2020
University of New Haven
2019
Universidad de Sevilla
2018
University Medical Center Groningen
2014
University of Groningen
2014
<b><i>Introduction:</i></b> Loss of skeletal muscle mass and function (sarcopenia) is common in individuals with obesity due to metabolic changes associated a sedentary lifestyle, adipose tissue derangements, comorbidities (acute chronic diseases) during the ageing process. Co-existence excess adiposity low mass/function referred as sarcopenic (SO), condition increasingly recognized for its clinical functional features that negatively influence important...
A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis insulin resistance. We have developed a highly specific small molecule inhibitor glucosylceramide synthase, an enzyme that catalyzes necessary step conversion to glycosphingolipids. In cultured 3T3-L1 adipocytes, iminosugar derivative N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynojirimycin (AMP-DNM) counteracted tumor necrosis factor-α–induced abnormalities concentrations and...
Bariatric surgery improves glucose metabolism. Recent data suggest that faecal microbiota transplantation (FMT) using faeces from postbariatric diet-induced obese mice in germ-free metabolism and intestinal homeostasis. We here investigated whether allogenic FMT post-Roux-en-Y gastric bypass donors (RYGB-D) compared with metabolic syndrome (METS-D) has short-term effects on metabolism, transit time adipose tissue inflammation treatment-naïve, obese, insulin-resistant male subjects.Subjects...
Loss of skeletal muscle mass and function (sarcopenia) is common in individuals with obesity due to metabolic changes associated a sedentary lifestyle, adipose tissue derangements, comorbidities (acute chronic diseases), during the ageing process. Co-existence excess adiposity low mass/function referred as sarcopenic (SO), condition increasingly recognized for its clinical functional features that negatively influence important patient-centred outcomes. Effective prevention treatment...
Obesity is a result of relative excess in energy intake over expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One the factors involved regulation food satiety dopaminergic signalling. A small number studies have reported that striatal dopamine D2/D3 receptor [D2/3R] availability lower morbidly obese subjects.To confirm role D2/3R obesity, we measured availability, using [123I]IBZM SPECT, 15 women non-obese controls.Striatal was 23%...
Thyrotoxicosis increases endogenous glucose production (EGP) and induces hepatic insulin resistance. We have recently shown that these alterations can be modulated by selective sympathetic parasympathetic denervation, pointing to neurally mediated effects of thyroid hormone on metabolism. Here, we investigated the central triiodothyronine (T(3)) administration EGP. used stable isotope dilution measure EGP before after i.c.v. bolus infusion T(3) or vehicle in euthyroid rats. To study role...
To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints a hepatocyte genome-scale metabolic model to investigate differences in liver, taking into account its interactions other tissues. Our systems level analysis predicted an altered demand for NAD+ glutathione (GSH)...
Background: Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated with beneficial metabolic effects. However, the direct effect of oral butyrate on parameters in humans has never studied. In this first men pilot study, we thus treated both lean and syndrome male subjects sodium investigated metabolism. Methods: Healthy males (n = 9) 10) were 4 g daily for weeks. Before after treatment, insulin sensitivity was determined by a two-step hyperinsulinemic euglycemic clamp...
The hypothalamic neuropeptide orexin influences (feeding) behavior as well energy metabolism. Administration of exogenous orexin-A into the brain has been shown to increase both food intake and blood glucose levels. In present study, we investigated role endogenous release in homeostasis rats.We effects system on basal production (EGP) hepatic peripheral insulin sensitivity by changing orexinergic activity hypothalamus combined with sympathetic or parasympathetic denervation, two-step...
American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar fat consumption have been implicated as a cause hepatic steatosis obesity but the effect meal pattern is largely understudied. We hypothesized that high frequency, compared consuming large meals, detrimental in accumulation intrahepatic abdominal fat. To test this hypothesis, we randomized 36 lean, healthy men 40% hypercaloric diet for 6 weeks or eucaloric control measured triglyceride content...
Highlights•The presence of hepatic steatosis is associated with insulin resistance•Intrahepatic triglycerides are not sufficient for resistance•Diacylglycerol in cytosol predicts inhibition glucose production•Diacylglycerol-associated resistance characterized by PKCε translocationSummaryHepatic lipid accumulation has been implicated the development resistance, but translational evidence humans limited. We investigated relationship between liver fat and tissue-specific sensitivity 133 obese...