A5019948448- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Bioinformatics and Genomic Networks
- Photosynthetic Processes and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Adenosine and Purinergic Signaling
- Sphingolipid Metabolism and Signaling
- Metabolism, Diabetes, and Cancer
- Cardiac Fibrosis and Remodeling
- Nuclear Receptors and Signaling
- Nitric Oxide and Endothelin Effects
- Plant biochemistry and biosynthesis
- Enzyme Catalysis and Immobilization
- Integrated Circuits and Semiconductor Failure Analysis
- Ion Transport and Channel Regulation
- Research in Cotton Cultivation
University of Gothenburg
2015-2024
Sahlgrenska University Hospital
2016-2024
Czech Academy of Sciences
2015-2017
Czech Academy of Sciences, Institute of Physiology
2015-2017
Charles University
2011-2013
Institute of Cell Biology
2011
Significance Hepatocellular carcinoma (HCC) is a heterogeneous and deadly form of liver cancer. Here, we stratified characterized HCC tumors by applying graph control theory concepts to the topology genome-scale metabolic networks. We identified three subtypes with distinct differences in signaling pathways clinical survival validated our results performing additional experiments. further subtype-specific genes pivotal controlling entire metabolism discovered that can be targeted for...
To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints a hepatocyte genome-scale metabolic model to investigate differences in liver, taking into account its interactions other tissues. Our systems level analysis predicted an altered demand for NAD+ glutathione (GSH)...
Abstract We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. first generated co‐expression networks ( CN s) 46 human tissues and cancer explore the functional relationships between genes examined overlap physical interactions. Since increased de novo lipogenesis is a characteristic of nonalcoholic fatty disease NAFLD ) hepatocellular carcinoma HCC ), we investigated liver‐specific co‐expressed acid...
BackgroundMyocardial ischemia is associated with alterations in cardiac metabolism, resulting decreased fatty acid oxidation and increased lipid accumulation. Here we investigate how myocardial content dynamics affect the function of ischemic heart, focus on role droplet protein perilipin 5 (Plin5) pathophysiology ischemia.Methods resultsWe generated Plin5−/− mice found that Plin5 deficiency dramatically reduced triglyceride heart. Under normal conditions, maintained a close to heart by...
Myocardial infarction (MI) promotes a range of systemic effects, many which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, adipose) mouse model (induced by ligating left ascending coronary artery) sham-operated mice. We performed genome-wide transcriptomic analysis on tissue samples obtained 6- 24 hr post or sham operation. By generating tissue-specific biological networks, observed:...
Ceramide accumulation is known to accompany acute myocardial ischemia, but its role in the pathogenesis of ischemic heart disease unclear. In this study, we aimed determine how ceramides accumulate and if cardiac function following ischemia can be improved by reducing ceramide accumulation.To investigate association between function, analyzed left ventricle biopsies from subjects with chronic found that levels were higher reduced function. Ceramides are produced either de novo synthesis or...
BackgroundRedox metabolism is often considered a potential target for cancer treatment, but systematic examination of redox responses in hepatocellular carcinoma (HCC) missing.MethodsHere, we employed systems biology and biological network analyses to reveal key roles genes associated with HCC by integrating multi-omics data.FindingsWe found that several genes, including 25 novel prognostic are significantly co-expressed liver-specific immunity inflammation. Based on an integrative analysis,...
Abstract Myocardial dysfunction is commonly associated with accumulation of cardiac lipid droplets (LDs). Perilipin 2 (Plin2) a LD protein that involved in formation, stability and trafficking events within the cell. Even though Plin2 highly expressed heart, little known about its role myocardial storage. A recent report shows overexpression result massive steatosis suggesting stabilizes LDs. In this study, we hypothesized deficiency would reduced contrast to our hypothesis, found increased...
Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids membrane lipids that important for cellular structure function, dysfunction is a characteristic rare monogenic diseases defects in glycosphingolipid synthesis turnover. However, it not known how glycosphingolipids regulate processes heart. The aim this study to determine role heart function.
Abstract Aims Pro-protein convertase subtilisin-kexin type 9 (PCSK9), which is expressed mainly in the liver and at low levels heart, regulates cholesterol by directing low-density lipoprotein receptors to degradation. Studies determine role of PCSK9 heart are complicated close link between cardiac function systemic lipid metabolism. Here, we sought elucidate specifically generating analysing mice with cardiomyocyte-specific Pcsk9 deficiency (CM-Pcsk9−/− mice) silencing acutely a cell...
CD36 fatty acid translocase plays a key role in supplying heart with its major energy substrate, long-chain acids (FA). Previously, we found that the spontaneously hypertensive rat (SHR) harbors deletion variant of Cd36 gene results reduced transport FA into cardiomyocytes and predisposes SHR to cardiac hypertrophy. In current study, analyzed effects mutant on susceptibility ischemic ventricular arrhythmias myocardial infarction adult SHR-Cd36 transgenic rats wild-type compared age-matched...
Highlights•Allele-specific cardiac MTTP expression makes the human heart vulnerable to ischemia.•MTTP-A deficient mice show impaired function after myocardial infarction.•No effect on expression, activity or lipid content in hearts of MTTP-A null mice•MTTP is linked separate biological processes compared liver.•Expression and genes mitochondrial associated heart.AbstractAimsThe microsomal triglyceride transport protein (MTTP) critical for assembly secretion apolipoprotein B (apoB)-containing...
Adaptation to chronic intermittent hypoxia (CIH) is associated with reactive oxygen species (ROS) generation implicated in the improved cardiac tolerance against acute ischemia–reperfusion injury. Phospholipases A 2 (PLA s) play an important role cardiomyocyte phospholipid metabolism influencing membrane homeostasis. Here we aimed determine effect of CIH (7000 m, 8 h/day, 5 weeks) on expression cytosolic PLA (cPLA α), its phosphorylated form (p-cPLA calcium-independent (iPLA ), and secretory...
Abstract/Summary Myocardial infarction (MI) promotes a range of systemic effects, many which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, adipose) mouse model (induced by ligating left ascending coronary artery) sham-operated mice. We performed genome-wide transcriptomic analysis on tissue samples obtained 6- 24-hours post or sham operation. By generating tissue-specific biological...