A5039027696- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Management and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Electroconvulsive Therapy Studies
Luye Pharma (China)
2025
University of Gothenburg
2014-2024
Sahlgrenska University Hospital
2015-2024
Academy of Military Medical Sciences
2024
Shaanxi University of Technology
2024
Ionis Pharmaceuticals (United States)
2024
AstraZeneca (Sweden)
2014-2023
University of Virginia
2022
Bispebjerg Hospital
2021
University of Copenhagen
2021
A systemic proinflammatory state has been hypothesized to mediate the association between comorbidities and abnormal cardiac structure/function in heart failure with preserved ejection fraction (HFpEF). We conducted a proteomic analysis investigate this paradigm.In 228 patients HFpEF from multicenter PROMIS-HFpEF study (Prevalence of Microvascular Dysfunction Heart Failure With Preserved Ejection Fraction), 248 unique circulating proteins were quantified by multiplex immunoassay (Olink) used...
Background/Objectives: Transforming Growth Factor-beta (TGFβ1) plays a core role in the process of pulmonary fibrosis (PF). The progression can be alleviated by siRNA-based inhibiting TGF-β1. However, limitations naked siRNA lead to failure achieving therapeutic effect. This study aimed design lipid nanoparticles (LNPs) that deliver siTGF-β1 lungs for purposes. Methods: cytotoxicity and transfection assay vitro were used screen ionizable lipids (ILs). Design Experiments (DOE) was obtain...
Background— Underlying mechanisms in heart failure (HF) with preserved ejection fraction remain unknown. We investigated cardiovascular plasma biomarkers HF and their correlation to diastolic dysfunction, functional class, pathophysiological processes, prognosis. Methods Results— In 86 stable patients EF ≥45% the Karolinska Rennes (KaRen) biomarker substudy, were quantified by a multiplex immunoassay. Orthogonal projection latent structures partial least square analysis was performed on 87...
Objective Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on clinical and echocardiogram data using machine learning, compare characteristics, proteomics outcomes across the phenogroups. Methods applied model-based clustering 32 11 laboratory variables collected in stable condition from 320 outpatients Karolinska-Rennes cohort study (56% female, median 78 years (IQR: 71–83)). Baseline...
It is commonly accepted that in obesity free fatty acids (FFA) cause insulin resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia observed subjects with normoglycaemia thus the paradigm above should be reevaluated.We describe two studies: MD-Lipolysis, a case control study investigating mechanisms of obesity-driven by systemic metabolic analysis, measurements adipose tissue lipolysis microdialysis, genomics; POEM, cohort used for validating differences...
Inflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.
Systemic microvascular dysfunction and inflammation are postulated to play a pathophysiologic role in heart failure with preserved ejection fraction (HFpEF). This study aimed identify biomarker profiles associated clinical outcomes HFpEF investigate how inhibition of the neutrophil-derived reactive oxygen species–producing enzyme, myeloperoxidase, affects these biomarkers. Using supervised principal component analyses, investigators assessed associations between baseline plasma proteomic...
Insulin reportedly impairs endothelial function in conduit arteries but improves it resistance and microvascular arterioles healthy humans. No studies have assessed at three arterial levels or metabolic syndrome (METSYN) subjects.The objective of the study was to compare responsiveness arteries, resistance, insulin METSYN subjects.We conduit, postabsorptive postprandial states during euglycemic hyperinsulinemia (insulin clamp).The conducted a clinical research unit.Age-matched subjects...
Abstract Impaired left atrial (LA) function in heart failure with preserved ejection fraction (HFpEF) is associated adverse outcomes. A subgroup of HFpEF may have LA myopathy out proportion to ventricular (LV) dysfunction; therefore, we sought characterize patients disproportionate myopathy. In the prospective, multicenter, Prevalence Microvascular Dysfunction study, defined based on degree reservoir strain abnormality relation LV (LV global longitudinal [GLS]) by calculating residuals from...
ABSTRACT Aim Epicardial adipose tissue (EAT) may play a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We investigated associations EAT proteomics, coronary flow reserve (CFR), cardiac structure and function, quality life (QoL) prospective multinational PROMIS‐HFpEF cohort. Methods results was measured by echocardiography 182 patients defined as increased if ≥9 mm. Proteins were using high‐throughput proximity extension assays. Microvascular...
Little information is available on sex differences in coronary microvascular dysfunction (CMD) heart failure with preserved ejection fraction (HFpEF). We investigated sex-specific proteomic profiles associated CMD patients HFpEF.
Total longitudinal displacement (tLoD) of the common carotid artery can be measured using ultrasound-based velocity vector imaging (VVI) technique. This study aimed to investigate clinical correlates and possible predictive value tLoD for cardiovascular outcome.Four hundred forty-one patients referred myocardial perfusion scintigraphy examination suspected coronary disease were recruited underwent VVI-assisted measurement. Patients followed up with regard major adverse event (MACE) 1 year...
AimsStress-induced cardiomyopathy (SIC) is an important differential diagnosis to acute myocardial infarction (AMI) that associated with significant morbidity and mortality. The typical hallmark of SIC left-ventricular apical akinesia but preserved function in basal segments. Catecholamines are postulated play role the precise pathophysiology incompletely understood. Whether perfusion affected segments impaired has been debated remains unknown.
BackgroundMyocardial ischemia is associated with alterations in cardiac metabolism, resulting decreased fatty acid oxidation and increased lipid accumulation. Here we investigate how myocardial content dynamics affect the function of ischemic heart, focus on role droplet protein perilipin 5 (Plin5) pathophysiology ischemia.Methods resultsWe generated Plin5−/− mice found that Plin5 deficiency dramatically reduced triglyceride heart. Under normal conditions, maintained a close to heart by...
Background Adenosine‐assisted transthoracic Doppler‐derived coronary flow reserve ( TDE ‐ CFR ) reflects vascular function. The prognostic and incremental value of left anterior descending artery above myocardial perfusion scintigraphy in patients with suspected ischemia has not yet been studied. Methods Results Three hundred seventy‐one (mean age, 62.3±8.7 years; 46.8% males) referred to attributed were included the study. result was blinded referring physician. Patients followed up...
Abstract Aims Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy and disarray, myocardial stiffness due to interstitial fibrosis, which result in impaired left ventricular filling diastolic dysfunction. The latter manifests as exercise intolerance, angina, dyspnoea. There currently no specific treatment for improving function HCM. Here, we investigated whether myeloperoxidase (MPO) expressed cardiomyocytes provides a novel therapeutic target alleviating...
Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex disease process influenced by metabolic disorders, systemic inflammation, myocardial fibrosis, and microvascular dysfunction. The goal of our study to identify potential relationships between plasma biomarkers cardiac magnetic resonance (CMR) imaging markers in patients HFpEF. Methods Nineteen subjects HFpEF 15 age-matched healthy controls were enrolled underwent multiparametric CMR biomarker analysis using the...
Evidence from animal studies indicates the importance of an interaction between sympathetic nervous system and endothelium for cardiovascular regulation. However these two systems remains largely unexplored in humans. The aim this study was to investigate whether directly recorded vasoconstrictor outflow is related a surrogate marker endothelial function healthy individuals.
Forced training has been shown to have beneficial vascular effects in various animal exercise models. In the present study, we explored possible physiological and molecular of voluntary physical on beds. SHR (spontaneously hypertensive rats) performed for 5 weeks a computerized wheel cage facility. Ex vivo myograph studies revealed an increased sensitivity ACh (acetylcholine)-mediated vasodilation resistance arteries exercised animals (ED50=15.0+/-3.5 nmol/l) compared with controls...